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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:gatifloxacin
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Accession:CHEBI:5280 term browser browse the term
Definition:A monocarboxylic acid that is 4-oxo-1,4-dihydroquinoline-3-carboxylic acid which is substituted on the nitrogen by a cyclopropyl group and at positions 6, 7, and 8 by fluoro, 3-methylpiperazin-1-yl, and methoxy groups, respectively. Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial topoisomerase type-II enzymes.
Synonyms:exact_synonym: 1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
 related_synonym: 1-Cyclopropyl-1,4-dihydro-6-fluoro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid;   1-cyclopropyl-6-fluoro- 8-methoxy-7-(3-methylpiperazin-1-yl)- 4-oxo-quinoline-3-carboxylic acid;   AM 1155;   Formula=C19H22FN3O4;   InChI=1S/C19H22FN3O4/c1-10-8-22(6-5-21-10)16-14(20)7-12-15(18(16)27-2)23(11-3-4-11)9-13(17(12)24)19(25)26/h7,9-11,21H,3-6,8H2,1-2H3,(H,25,26);   InChIKey=XUBOMFCQGDBHNK-UHFFFAOYSA-N;   SMILES=COc1c(N2CCNC(C)C2)c(F)cc2c1n(cc(C(O)=O)c2=O)C1CC1;   gatifloxacine;   gatifloxacino;   gatifloxacinum
 alt_id: CHEBI:101712
 xref: Beilstein:7445861;   CAS:112811-59-3;   DrugBank:DB01044;   Drug_Central:1280;   Gmelin:2281206;   KEGG:C07661;   KEGG:D08011;   LINCS:LSM-5139
 xref_mesh: MESH:C078049
 xref: PMID:10737746;   PMID:12190308;   PMID:12620077;   PMID:12873512;   PMID:12904069;   PMID:15125930;   PMID:15745831;   PMID:15911273;   PMID:16078842;   PMID:16337791;   PMID:16554151;   PMID:16759086;   PMID:17043111;   PMID:17043131;   PMID:17064062;   PMID:17116666;   PMID:17116668;   PMID:17157008;   PMID:17220425;   PMID:17261623;   PMID:17276057;   PMID:17296740;   PMID:17325221;   PMID:17387152;   PMID:17804222;   PMID:17933535;   PMID:17960928;   PMID:18078756;   PMID:18304818;   PMID:26963935;   PMID:7473575;   Patent:EP230295;   Patent:US4980470;   Reaxys:7445861;   Wikipedia:Gatifloxacin


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gatifloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gcg glucagon increases secretion
increases expression
multiple interactions
ISO
EXP
gatifloxacin results in increased secretion of GCG protein
gatifloxacin results in increased expression of GCG mRNA
Diazoxide inhibits the reaction [gatifloxacin results in increased secretion of GCG protein]
[gatifloxacin co-treated with GCG protein] affects the secretion of INS1 protein; GCG protein affects the reaction [gatifloxacin results in decreased expression of INS2 mRNA]; GCG protein promotes the reaction [gatifloxacin affects the expression of GCGR mRNA]
gatifloxacin results in increased expression of GCG protein
CTD PMID:23200776 NCBI chr 3:48,442,635...48,451,650
Ensembl chr 3:48,442,635...48,451,650
JBrowse link
G Gcgr glucagon receptor multiple interactions
affects expression
EXP GCG protein promotes the reaction [gatifloxacin affects the expression of GCGR mRNA] CTD PMID:23200776 NCBI chr10:109,707,863...109,716,253
Ensembl chr10:109,707,962...109,716,128
JBrowse link
G Ins2 insulin 2 multiple interactions
decreases expression
EXP GCG protein affects the reaction [gatifloxacin results in decreased expression of INS2 mRNA] CTD PMID:23200776 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Pcsk1 proprotein convertase subtilisin/kexin type 1 increases expression ISO gatifloxacin results in increased expression of PCSK1 mRNA CTD PMID:23200776 NCBI chr 2:91,450,162...91,497,091
Ensembl chr 2:91,450,162...91,497,091
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        antimicrobial agent 17312
          gatifloxacin 4
            (R)-gatifloxacin 0
            (S)-gatifloxacin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        aromatic carboxylic acid 10889
                                          quinolinemonocarboxylic acid 95
                                            gatifloxacin 4
                                              (R)-gatifloxacin 0
                                              (S)-gatifloxacin 0
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