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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cytochalasin D
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Accession:CHEBI:529996 term browser browse the term
Definition:An organic heterotricyclic compound that is a mycotoxin produced by Helminthosporium and other moulds which is cell permeable and a potent inhibitor of actin polymerisation and DNA synthesis.
Synonyms:exact_synonym: (3S,3aR,4S,6S,7E,10S,12R,13E,15R,15aR)-3-benzyl-6,12-dihydroxy-4,10,12-trimethyl-5-methylene-1,11-dioxo-2,3,3a,4,5,6,6a,9,10,11,12,15-dodecahydro-1H-cycloundeca[d]isoindol-15-yl acetate
 related_synonym: 7,18-Dihydroxy-10-phenyl-5,16,18-trimethyl-(11)cytochalas-21-acetoxy-6(12),13,19-trien-17-one;   Cytohalasin D;   Formula=C30H37NO6;   InChI=1S/C30H37NO6/c1-17-10-9-13-22-26(33)19(3)18(2)25-23(16-21-11-7-6-8-12-21)31-28(35)30(22,25)24(37-20(4)32)14-15-29(5,36)27(17)34/h6-9,11-15,17-18,22-26,33,36H,3,10,16H2,1-2,4-5H3,(H,31,35)/b13-9+,15-14+/t17-,18+,22?,23-,24+,25-,26+,29+,30+/m0/s1;   InChIKey=SDZRWUKZFQQKKV-FJUULPFHSA-N;   Lygosporin A;   SMILES=[H][C@]12[C@H](Cc3ccccc3)NC(=O)[C@]11[C@H](OC(C)=O)\\C=C\\[C@@](C)(O)C(=O)[C@@H](C)C\\C=C\\C1[C@H](O)C(=C)[C@H]2C;   Zygosporin A
 xref: Beilstein:1632828;   CAS:22144-77-0
 xref_mesh: MESH:D015638
 xref: PDBeChem:CY9;   PMID:20010439;   PMID:22305779;   PMID:22684244;   PMID:22728040;   PMID:23615686;   PMID:5800426;   PMID:7199049;   Reaxys:1632828;   Wikipedia:Cytochalasin_D


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cytochalasin D term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase multiple interactions
increases phosphorylation
ISO EGF protein inhibits the reaction [Cytochalasin D results in increased phosphorylation of ABL1 protein] CTD PMID:21900236 NCBI chr 3:10,041,820...10,145,076
Ensembl chr 3:10,041,826...10,144,388
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions
increases expression
ISO
EXP
Cytochalasin D inhibits the reaction [Oxygen results in increased expression of ACTA2 mRNA]; Cytochalasin D inhibits the reaction [Oxygen results in increased expression of ACTA2 protein]
Cytochalasin D results in increased expression of ACTA2 mRNA
CTD PMID:11035001, PMID:23517783 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Actg1 actin, gamma 1 multiple interactions ISO Cytochalasin D inhibits the reaction [UPF1 protein binds to ACTG1 protein]; Cytochalasin D inhibits the reaction [UPF2 protein binds to ACTG1 protein]; Cytochalasin D inhibits the reaction [UPF3B protein binds to ACTG1 protein] CTD PMID:28743738 NCBI chr10:109,518,429...109,521,288
Ensembl chr 3:75,643,054...75,644,954
Ensembl chr10:75,643,054...75,644,954
JBrowse link
G Cdh1 cadherin 1 multiple interactions
increases expression
ISO [Cytochalasin D results in increased expression of CDH1 protein] which results in decreased activity of RHOA protein; RHOA protein mutant form affects the reaction [Cytochalasin D results in increased expression of CDH1 protein]
Cytochalasin D results in increased expression of CDH1 mRNA; Cytochalasin D results in increased expression of CDH1 protein
CTD PMID:25756282 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO Cytochalasin D inhibits the reaction [Oxygen results in increased expression of COL1A1 mRNA] CTD PMID:23517783 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions ISO Cytochalasin D inhibits the reaction [Oxygen results in increased expression of COL1A2 mRNA] CTD PMID:23517783 NCBI chr 4:31,534,225...31,569,152
Ensembl chr 4:31,534,225...31,569,151
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Cytochalasin D inhibits the reaction [Particulate Matter results in increased secretion of CSF2 protein]; Cytochalasin D inhibits the reaction [Vehicle Emissions results in increased secretion of CSF2 protein] CTD PMID:10645887 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 multiple interactions ISO Cytochalasin D promotes the reaction [CXCL8 protein results in decreased expression of CXCR1 protein] CTD PMID:11145710 NCBI chr 9:81,466,430...81,469,299
Ensembl chr 9:81,466,332...81,469,274
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 multiple interactions ISO Cytochalasin D promotes the reaction [CXCL8 protein results in decreased expression of CXCR2 protein] CTD PMID:11145710 NCBI chr 9:81,427,275...81,435,065
Ensembl chr 9:81,427,730...81,434,102
JBrowse link
G Egf epidermal growth factor multiple interactions ISO EGF protein inhibits the reaction [Cytochalasin D results in increased phosphorylation of ABL1 protein] CTD PMID:21900236 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Cytochalasin D inhibits the reaction [Asbestos, Crocidolite results in decreased phosphorylation of EGFR protein] CTD PMID:15626777 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO Cytochalasin D inhibits the reaction [Particulate Matter results in increased expression of F3 mRNA] CTD PMID:25858758 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Gpx1 glutathione peroxidase 1 affects localization ISO Cytochalasin D affects the localization of GPX1 mRNA mutant form CTD PMID:28743738 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Cytochalasin D inhibits the reaction [TNF protein affects the localization of ICAM1 protein] CTD PMID:15034928 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma multiple interactions ISO Cytochalasin D promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA] CTD PMID:12799187 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta increases phosphorylation
multiple interactions
ISO Cytochalasin D results in increased phosphorylation of IKBKB protein
Cytochalasin D results in decreased localization of [IKBKB protein binds to NFKBIA protein]
CTD PMID:17029595 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Cytochalasin D inhibits the reaction [[Lipopolysaccharides co-treated with Silicon Dioxide] results in increased cleavage of and results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of and results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with aluminum sulfate] results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [Asbestos, Crocidolite results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [Nanotubes, Carbon results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [titanium dioxide results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; Cytochalasin D promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA] CTD PMID:12799187, PMID:18403674, PMID:18604214, PMID:24158569, PMID:24760326, PMID:30320338 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 decreases chemical synthesis
increases stability
ISO Cytochalasin D results in decreased chemical synthesis of IL6 protein
Cytochalasin D results in increased stability of IL6 mRNA
CTD PMID:16499908 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ivns1abp influenza virus NS1A binding protein increases response to substance ISO IVNS1ABP gene mutant form results in increased susceptibility to Cytochalasin D CTD PMID:15485691 NCBI chr13:68,702,970...68,722,472
Ensembl chr13:68,702,820...68,722,472
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Cytochalasin D promotes the reaction [TNF results in increased expression of MMP9 mRNA] CTD PMID:17560598 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mrtfa myocardin related transcription factor A multiple interactions ISO Cytochalasin D inhibits the reaction [Oxygen affects the localization of MRTFA protein] CTD PMID:23517783 NCBI chr 7:122,233,196...122,403,661
Ensembl chr 7:122,234,012...122,403,667
JBrowse link
G Nfatc4 nuclear factor of activated T-cells 4 decreases localization ISO Cytochalasin D results in decreased localization of NFATC4 protein CTD PMID:17044076 NCBI chr15:34,493,163...34,502,238
Ensembl chr15:34,493,138...34,504,326
JBrowse link
G Nfkbia NFKB inhibitor alpha increases phosphorylation
multiple interactions
ISO Cytochalasin D results in increased phosphorylation of NFKBIA protein
Cytochalasin D results in decreased localization of [IKBKB protein binds to NFKBIA protein]
CTD PMID:17029595 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Cytochalasin D promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA] CTD PMID:12799187 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G P2rx1 purinergic receptor P2X 1 decreases activity ISO Cytochalasin D results in decreased activity of P2RX1 protein CTD PMID:21757694 NCBI chr10:59,566,268...59,581,328
Ensembl chr10:59,566,223...59,581,325
JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 decreases uptake ISO Cytochalasin D results in decreased uptake of PDX1 protein CTD PMID:16405074 NCBI chr12:9,496,044...9,501,211
Ensembl chr12:9,496,044...9,501,213
JBrowse link
G Plat plasminogen activator, tissue type increases expression ISO Cytochalasin D results in increased expression of PLAT CTD PMID:12371961 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO [Cytochalasin D results in increased expression of CDH1 protein] which results in decreased activity of RHOA protein; RHOA protein mutant form affects the reaction [Cytochalasin D results in increased expression of CDH1 protein] CTD PMID:25756282 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Rs1 retinoschisin 1 decreases secretion ISO Cytochalasin D results in decreased secretion of RS1 protein CTD PMID:21738583 NCBI chr  X:35,749,957...35,777,243
Ensembl chr  X:35,749,957...35,777,243
JBrowse link
G Slc31a1 solute carrier family 31 member 1 multiple interactions ISO Cytochalasin D inhibits the reaction [Cisplatin results in increased degradation of SLC31A1 protein] CTD PMID:17108132 NCBI chr 5:78,222,504...78,249,358
Ensembl chr 5:78,222,504...78,249,358
JBrowse link
G Smad1 SMAD family member 1 affects localization ISO Cytochalasin D affects the localization of SMAD1 protein CTD PMID:25756282 NCBI chr19:32,182,942...32,248,694
Ensembl chr19:32,188,267...32,248,684
JBrowse link
G Smad2 SMAD family member 2 affects localization ISO Cytochalasin D affects the localization of SMAD2 protein CTD PMID:25756282 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Smad3 SMAD family member 3 affects localization ISO Cytochalasin D affects the localization of SMAD3 protein CTD PMID:25756282 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Snai1 snail family transcriptional repressor 1 affects localization ISO Cytochalasin D affects the localization of SNAI1 protein CTD PMID:25756282 NCBI chr 3:164,274,710...164,279,199
Ensembl chr 3:164,274,710...164,279,378
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Cytochalasin D deficiency results in decreased activity of and affects the localization of STAT1 protein CTD PMID:28086195 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Cytochalasin D deficiency results in decreased activity of and affects the localization of STAT3 protein CTD PMID:28086195 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tagln transgelin increases expression EXP Cytochalasin D results in increased expression of TAGLN mRNA CTD PMID:11035001 NCBI chr 8:50,222,895...50,228,369
Ensembl chr 8:50,222,896...50,231,357
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Cytochalasin D inhibits the reaction [TNF protein affects the localization of ICAM1 protein]; Cytochalasin D inhibits the reaction [TNF protein affects the localization of VCAM1 protein]; Cytochalasin D inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Cytochalasin D promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]; Cytochalasin D promotes the reaction [TNF results in increased expression of MMP9 mRNA]
Cytochalasin D inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Cytochalasin D inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
CTD PMID:8409756, PMID:12799187, PMID:15034928, PMID:17560598 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Txn1 thioredoxin 1 multiple interactions ISO Cytochalasin D inhibits the reaction [Cadmium Chloride affects the localization of TXN protein] CTD PMID:22961094 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Upf1 UPF1, RNA helicase and ATPase affects localization
multiple interactions
ISO Cytochalasin D affects the localization of UPF1 protein
Cytochalasin D inhibits the reaction [UPF1 protein binds to ACTG1 protein]
CTD PMID:28743738 NCBI chr16:20,824,888...20,845,632
Ensembl chr16:20,824,864...20,845,243
JBrowse link
G Upf2 UPF2, regulator of nonsense mediated mRNA decay multiple interactions ISO Cytochalasin D inhibits the reaction [UPF2 protein binds to ACTG1 protein] CTD PMID:28743738 NCBI chr17:76,176,379...76,287,246
Ensembl chr17:76,175,643...76,287,186
JBrowse link
G Upf3b UPF3B, regulator of nonsense mediated mRNA decay multiple interactions ISO Cytochalasin D inhibits the reaction [UPF3B protein binds to ACTG1 protein] CTD PMID:28743738 NCBI chr  X:123,713,327...123,731,431
Ensembl chr  X:123,713,339...123,731,385
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Cytochalasin D inhibits the reaction [TNF protein affects the localization of VCAM1 protein]; Cytochalasin D inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:15034928 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        inhibitor 18247
          actin polymerisation inhibitor 59
            cytochalasin D 43
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18114
                                        carboacyl group 17372
                                          univalent carboacyl group 17372
                                            carbamoyl group 17158
                                              carboxamide 17158
                                                lactam 8034
                                                  gamma-lactam 6269
                                                    cytochalasin D 43
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.