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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:gastrointestinal drug
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Accession:CHEBI:55324 term browser browse the term
Definition:A drug used for its effects on the gastrointestinal system, e.g. controlling gastric acidity, regulating gastrointestinal motility and water flow, and improving digestion.
Synonyms:related_synonym: gastrointestinal agent;   gastrointestinal agents;   gastrointestinal drugs


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16,16-dimethylprostaglandin E2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
ISO 16,16-Dimethylprostaglandin E2 results in increased phosphorylation of AKT1 protein
EGFR affects the reaction [16,16-Dimethylprostaglandin E2 results in increased phosphorylation of AKT1 protein]
CTD PMID:15578100 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases response to substance
affects localization
ISO BAX results in increased susceptibility to 16,16-Dimethylprostaglandin E2
16,16-Dimethylprostaglandin E2 affects the localization of BAX protein
CTD PMID:15578100 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO EGFR affects the reaction [16,16-Dimethylprostaglandin E2 results in increased phosphorylation of AKT1 protein] CTD PMID:15578100 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase increases activity ISO 16,16-Dimethylprostaglandin E2 results in increased activity of HPGD protein CTD PMID:14736730 NCBI chr16:37,457,134...37,495,758
Ensembl chr16:37,457,135...37,495,758
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP 16,16-Dimethylprostaglandin E2 inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:11686837, PMID:11855677, PMID:11991626, PMID:18306037 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP 16,16-Dimethylprostaglandin E2 inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]; 16,16-Dimethylprostaglandin E2 inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA] CTD PMID:11686837, PMID:11855677, PMID:11991626, PMID:15610444, PMID:18306037 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO
EXP
Flurbiprofen inhibits the reaction [16,16-Dimethylprostaglandin E2 results in increased expression of PTGS2 mRNA]
16,16-Dimethylprostaglandin E2 inhibits the reaction [SC 560 results in increased expression of PTGS2 mRNA]
CTD PMID:9099957, PMID:15610444 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 16,16-Dimethylprostaglandin E2 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF] CTD PMID:9298541 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
3,7,12-trioxo-5beta-cholanic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhrs11 dehydrogenase/reductase 11 increases reduction ISO DHRS11 protein results in increased reduction of Dehydrocholic Acid CTD PMID:30926317 NCBI chr10:72,144,042...72,153,496
Ensembl chr10:72,144,042...72,153,375
JBrowse link
auraptene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO aurapten promotes the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]; aurapten promotes the reaction [ABCB1 protein results in increased import of Daunorubicin] CTD PMID:18955043 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Ccna2 cyclin A2 affects expression ISO aurapten affects the expression of CCNA2 mRNA CTD PMID:23320178 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb2 cyclin B2 affects expression ISO aurapten affects the expression of CCNB2 mRNA CTD PMID:23320178 NCBI chr 8:76,847,972...76,861,165 JBrowse link
G Cdc45 cell division cycle 45 affects expression ISO aurapten affects the expression of CDC45 mRNA CTD PMID:23320178 NCBI chr11:86,328,785...86,354,099
Ensembl chr11:86,329,012...86,358,453
JBrowse link
G Cdk1 cyclin-dependent kinase 1 affects expression ISO aurapten affects the expression of CDK1 mRNA CTD PMID:23320178 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B affects expression ISO aurapten affects the expression of CDKN2B mRNA CTD PMID:23320178 NCBI chr 5:107,834,353...107,857,428
Ensembl chr 5:107,845,951...107,858,104
JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C affects expression ISO aurapten affects the expression of CDKN2C mRNA CTD PMID:23320178 NCBI chr 5:129,347,731...129,352,886
Ensembl chr 5:129,347,732...129,352,886
JBrowse link
G Chek1 checkpoint kinase 1 affects expression ISO aurapten affects the expression of CHEK1 mRNA CTD PMID:23320178 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Chek2 checkpoint kinase 2 affects expression ISO aurapten affects the expression of CHEK2 mRNA CTD PMID:23320178 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Ctnnb1 catenin beta 1 decreases expression EXP aurapten results in decreased expression of CTNNB1 protein mutant form CTD PMID:16012713 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO aurapten inhibits the reaction [DDT results in increased expression of CYP1A1 mRNA]; aurapten inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:20865247 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 affects expression ISO aurapten affects the expression of DDIT3 mRNA CTD PMID:23320178 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dusp1 dual specificity phosphatase 1 affects expression ISO aurapten affects the expression of DUSP1 mRNA CTD PMID:23320178 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
JBrowse link
G E2f1 E2F transcription factor 1 affects expression ISO aurapten affects the expression of E2F1 mRNA CTD PMID:23320178 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
G E2f2 E2F transcription factor 2 affects expression ISO aurapten affects the expression of E2F2 mRNA CTD PMID:23320178 NCBI chr 5:154,516,611...154,540,228
Ensembl chr 5:154,522,119...154,540,265
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha affects expression ISO aurapten affects the expression of GADD45A mRNA CTD PMID:23320178 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit affects expression ISO aurapten affects the expression of JUN mRNA CTD PMID:23320178 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kif20b kinesin family member 20B affects expression ISO aurapten affects the expression of KIF20B mRNA CTD PMID:23320178 NCBI chr 1:253,220,038...253,275,523
Ensembl chr 1:253,221,812...253,275,490
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 affects expression ISO aurapten affects the expression of MCM3 mRNA CTD PMID:23320178 NCBI chr 9:26,914,057...26,932,201
Ensembl chr 9:26,914,057...26,932,201
JBrowse link
G Mcm6 minichromosome maintenance complex component 6 affects expression ISO aurapten affects the expression of MCM6 mRNA CTD PMID:23320178 NCBI chr13:45,042,882...45,068,073
Ensembl chr13:45,042,882...45,068,077
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects response to substance ISO NFE2L2 protein affects the susceptibility to aurapten CTD PMID:19150646 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO aurapten inhibits the reaction [DDT results in increased expression of PTGS2 mRNA]; aurapten inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA] CTD PMID:20865247 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 affects expression ISO aurapten affects the expression of UHRF1 mRNA CTD PMID:23320178 NCBI chr 9:10,738,211...10,758,403
Ensembl chr 9:10,738,222...10,757,954
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO aurapten inhibits the reaction [DDT results in increased expression of VEGFA mRNA]; aurapten inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of VEGFA mRNA] CTD PMID:20865247 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
balsalazide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mpo myeloperoxidase decreases activity ISO balsalazide results in decreased activity of MPO protein CTD PMID:19296261 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
ceruletide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions
increases expression
ISO PTHLH protein promotes the reaction [Ceruletide results in increased expression of ACTA2 protein] CTD PMID:25035110 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Ahcy adenosylhomocysteinase decreases expression EXP Ceruletide results in decreased expression of AHCY protein CTD PMID:18024178 NCBI chr 3:150,587,833...150,603,057
Ensembl chr 3:150,587,833...150,603,082
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B increases expression EXP Ceruletide results in increased expression of AKR1B1 protein CTD PMID:18024178 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO (+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of AKT1 protein]; [KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of AKT1 protein CTD PMID:26390243 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alb albumin decreases expression EXP Ceruletide results in decreased expression of ALB protein modified form CTD PMID:17169977 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Bdkrb1 bradykinin receptor B1 increases expression ISO Ceruletide results in increased expression of BDKRB1 mRNA CTD PMID:21484880 NCBI chr 6:129,437,423...129,441,553
Ensembl chr 6:129,438,158...129,440,574
JBrowse link
G Bdkrb2 bradykinin receptor B2 increases expression ISO Ceruletide results in increased expression of BDKRB2 mRNA CTD PMID:21484880 NCBI chr 6:129,399,468...129,429,676
Ensembl chr 6:129,399,468...129,429,676
JBrowse link
G Brd4 bromodomain containing 4 multiple interactions ISO (+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased expression of BRD4 protein]; [KRAS protein mutant form co-treated with Ceruletide] results in increased expression of BRD4 protein CTD PMID:26390243 NCBI chr 7:14,222,101...14,303,055
Ensembl chr 7:14,222,101...14,303,055
JBrowse link
G Casp3 caspase 3 multiple interactions EXP [Glycodeoxycholic Acid co-treated with Ceruletide] results in decreased activity of CASP3 protein; Ceruletide results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:16339139, PMID:18832452 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions EXP Ceruletide results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:16339139 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions EXP Ceruletide results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:16339139 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression
ISO PPARG affects the reaction [Ceruletide results in increased expression of CCL2 mRNA]; rosiglitazone inhibits the reaction [Ceruletide results in increased expression of CCL2 mRNA] CTD PMID:17463185, PMID:21484880 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cct2 chaperonin containing TCP1 subunit 2 increases expression EXP Ceruletide results in increased expression of CCT2 protein CTD PMID:18024178 NCBI chr 7:60,106,532...60,122,779
Ensembl chr 7:60,109,974...60,122,805
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha increases expression
multiple interactions
EXP Ceruletide results in increased expression of CEBPA mRNA
[Dietary Fats co-treated with Ceruletide] results in increased expression of CEBPA protein; Dietary Fats promotes the reaction [Ceruletide results in increased expression of CEBPA mRNA]; Quercetin inhibits the reaction [[Dietary Fats co-treated with Ceruletide] results in increased expression of CEBPA protein]; Quercetin inhibits the reaction [Ceruletide results in increased expression of CEBPA mRNA]
CTD PMID:26873426 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions
increases expression
EXP [Dietary Fats co-treated with Ceruletide] results in increased expression of CEBPB protein; Dietary Fats promotes the reaction [Ceruletide results in increased expression of CEBPB mRNA]; Quercetin inhibits the reaction [[Dietary Fats co-treated with Ceruletide] results in increased expression of CEBPB protein]; Quercetin inhibits the reaction [Ceruletide results in increased expression of CEBPB mRNA] CTD PMID:26873426 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
increases expression
ISO
EXP
PTHLH protein modified form inhibits the reaction [Ceruletide results in increased expression of COL1A1 mRNA]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of COL1A1 mRNA]
PTHLH protein inhibits the reaction [Ceruletide results in increased expression of COL1A1 mRNA]
CTD PMID:22280800, PMID:25035110 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Ctsb cathepsin B affects localization
multiple interactions
EXP Ceruletide affects the localization of CTSB protein
sodium arsenite inhibits the reaction [Ceruletide affects the localization of CTSB protein]
CTD PMID:17941083 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression
multiple interactions
ISO Ceruletide results in increased expression of CXCL1 mRNA
AM 251 inhibits the reaction [Ceruletide results in increased expression of CXCL1 mRNA]; AM 251 promotes the reaction [iodopravadoline inhibits the reaction [Ceruletide results in increased expression of CXCL1 mRNA]]; HU 211 inhibits the reaction [Ceruletide results in increased expression of CXCL1 mRNA]; iodopravadoline inhibits the reaction [Ceruletide results in increased expression of CXCL1 mRNA]; iodopravadoline promotes the reaction [AM 251 inhibits the reaction [Ceruletide results in increased expression of CXCL1 mRNA]]; PPARG affects the reaction [Ceruletide results in increased expression of CXCL1 mRNA]
CTD PMID:17463185, PMID:17484889 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases expression
multiple interactions
EXP Ceruletide results in increased expression of ERN1 mRNA; Ceruletide results in increased expression of ERN1 protein
Dietary Fats promotes the reaction [Ceruletide results in increased expression of ERN1 mRNA]; Dietary Fats promotes the reaction [Ceruletide results in increased expression of ERN1 protein]; Quercetin inhibits the reaction [Ceruletide results in increased expression of ERN1 mRNA]; Quercetin inhibits the reaction [Ceruletide results in increased expression of ERN1 protein]
CTD PMID:26873426 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Glud1 glutamate dehydrogenase 1 increases expression EXP Ceruletide results in increased expression of GLUD1 protein CTD PMID:18024178 NCBI chr16:10,661,486...10,695,557
Ensembl chr16:10,662,021...10,695,557
JBrowse link
G Hnrnph1 heterogeneous nuclear ribonucleoprotein H1 increases expression EXP Ceruletide results in increased expression of HNRNPH1 protein CTD PMID:18024178 NCBI chr10:35,872,619...35,879,911
Ensembl chr10:35,870,232...35,879,910
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases expression EXP Ceruletide results in decreased expression of HSPA5 protein CTD PMID:18024178 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 decreases expression EXP Ceruletide results in decreased expression of HSPA8 protein CTD PMID:18024178 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Hyou1 hypoxia up-regulated 1 increases expression EXP Ceruletide results in increased expression of HYOU1 protein CTD PMID:18024178 NCBI chr 8:48,699,796...48,711,912
Ensembl chr 8:48,699,769...48,711,910
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
increases expression
ISO PTHLH protein modified form inhibits the reaction [Ceruletide results in increased expression of ICAM1 mRNA]
rosiglitazone inhibits the reaction [Ceruletide results in increased expression of ICAM1 mRNA]
CTD PMID:17463185, PMID:25035110 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il10 interleukin 10 multiple interactions EXP [resveratrol co-treated with Ceruletide] results in increased expression of IL10 protein CTD PMID:24234420 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
increases secretion
EXP
ISO
Ceruletide results in increased expression of IL1B mRNA; Ceruletide results in increased expression of IL1B protein
Dietary Fats promotes the reaction [Ceruletide results in increased expression of IL1B mRNA]; Dietary Fats promotes the reaction [Ceruletide results in increased secretion of IL1B protein]; Quercetin inhibits the reaction [Ceruletide results in increased expression of IL1B mRNA]; Quercetin inhibits the reaction [Dietary Fats promotes the reaction [Ceruletide results in increased expression of IL1B mRNA]]; resveratrol inhibits the reaction [Ceruletide results in increased expression of IL1B protein]
CTD PMID:14751415, PMID:21484880, PMID:24234420, PMID:26873426 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
increases secretion
ISO
EXP
Ceruletide results in increased expression of IL6 mRNA
Dietary Fats promotes the reaction [Ceruletide results in increased expression of IL6 mRNA]; Dietary Fats promotes the reaction [Ceruletide results in increased secretion of IL6 protein]; PTHLH protein inhibits the reaction [Ceruletide results in increased expression of IL6 mRNA]; Quercetin inhibits the reaction [Ceruletide results in increased expression of IL6 mRNA]; Quercetin inhibits the reaction [Dietary Fats promotes the reaction [Ceruletide results in increased expression of IL6 mRNA]]
(+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased expression of IL6 protein]; [KRAS protein mutant form co-treated with Ceruletide] results in increased expression of IL6 protein; HU 211 inhibits the reaction [Ceruletide results in increased expression of IL6 protein]; IL6 protein inhibits the reaction [(+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of STAT3 protein]]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of IL6 mRNA]
Ceruletide results in increased expression of IL6 mRNA; Ceruletide results in increased expression of IL6 protein
PTHLH protein modified form inhibits the reaction [Ceruletide results in increased expression of IL6 mRNA]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of IL6 mRNA]
CTD PMID:17484889, PMID:22280800, PMID:25035110, PMID:26390243, PMID:26873426 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
ISO Ceruletide results in increased expression of JUN mRNA
rosiglitazone inhibits the reaction [Ceruletide results in increased expression of JUN mRNA]
CTD PMID:17463185 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions ISO (+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased expression of BRD4 protein]; (+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased expression of IL6 protein]; (+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of AKT1 protein]; (+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of STAT3 protein]; [KRAS protein mutant form co-treated with Ceruletide] results in increased expression of BRD4 protein; [KRAS protein mutant form co-treated with Ceruletide] results in increased expression of IL6 protein; [KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of AKT1 protein; [KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of STAT3 protein; IL6 protein inhibits the reaction [(+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of STAT3 protein]] CTD PMID:26390243 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
JBrowse link
G Mir216a microRNA 216a increases expression EXP Ceruletide results in increased expression of MIR216A mRNA CTD PMID:27521901 NCBI chr14:113,112,129...113,112,234
Ensembl chr14:113,112,129...113,112,234
JBrowse link
G Mir216b microRNA 216b increases expression EXP Ceruletide results in increased expression of MIR216B mRNA CTD PMID:27521901 NCBI chr14:113,101,078...113,101,179
Ensembl chr14:113,101,078...113,101,179
JBrowse link
G Mir217 microRNA 217 increases expression EXP Ceruletide results in increased expression of MIR217 mRNA CTD PMID:27521901 NCBI chr14:113,119,529...113,119,633
Ensembl chr14:113,119,529...113,119,633
JBrowse link
G Mpo myeloperoxidase increases expression
multiple interactions
ISO Ceruletide results in increased expression of MPO protein
HU 211 inhibits the reaction [Ceruletide results in increased expression of MPO protein]
CTD PMID:17484889 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nfkbia NFKB inhibitor alpha increases degradation
multiple interactions
EXP Ceruletide results in increased degradation of NFKBIA protein
sodium arsenite inhibits the reaction [Ceruletide results in increased degradation of NFKBIA protein]
CTD PMID:17941083 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Pdia4 protein disulfide isomerase family A, member 4 increases expression EXP Ceruletide results in increased expression of PDIA4 protein CTD PMID:18024178 NCBI chr 4:77,470,636...77,489,535
Ensembl chr 4:77,470,636...77,489,535
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO PPARG affects the reaction [Ceruletide results in increased expression of CCL2 mRNA]; PPARG affects the reaction [Ceruletide results in increased expression of CXCL1 mRNA] CTD PMID:17463185 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Prdx2 peroxiredoxin 2 increases expression EXP Ceruletide results in increased expression of PRDX2 protein CTD PMID:18024178 NCBI chr19:26,084,816...26,090,095
Ensembl chr19:26,084,903...26,090,094
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression EXP Ceruletide results in increased expression of PTGS2 mRNA; Ceruletide results in increased expression of PTGS2 protein CTD PMID:14751415 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Pthlh parathyroid hormone-like hormone multiple interactions
affects response to substance
increases expression
ISO
EXP
PTHLH protein modified form inhibits the reaction [Ceruletide results in increased expression of COL1A1 mRNA]; PTHLH protein modified form inhibits the reaction [Ceruletide results in increased expression of ICAM1 mRNA]; PTHLH protein modified form inhibits the reaction [Ceruletide results in increased expression of IL6 mRNA]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of COL1A1 mRNA]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of IL6 mRNA]
Ethanol results in increased susceptibility to [Ceruletide results in increased expression of PTHLH mRNA]; PTHLH protein inhibits the reaction [Ceruletide results in increased expression of COL1A1 mRNA]; PTHLH protein inhibits the reaction [Ceruletide results in increased expression of IL6 mRNA]
PTHLH protein affects the susceptibility to Ceruletide
Ceruletide results in increased expression of PTHLH mRNA; Ceruletide results in increased expression of PTHLH protein
PTHLH protein promotes the reaction [Ceruletide results in increased expression of ACTA2 protein]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of COL1A1 mRNA]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of IL6 mRNA]
CTD PMID:22280800, PMID:25035110 NCBI chr 4:181,663,425...181,674,181 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression
ISO ent-1,3,6,11-tetrahydroxykaur-16-ene-15-one 3,11-diacetate inhibits the reaction [Ceruletide results in increased expression of RELA protein] CTD PMID:22982818 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 increases cleavage EXP Ceruletide results in increased cleavage of RIPK1 protein CTD PMID:16339139 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904
JBrowse link
G Ruvbl1 RuvB-like AAA ATPase 1 increases expression EXP Ceruletide results in increased expression of RUVBL1 protein CTD PMID:18024178 NCBI chr 4:120,411,917...120,447,458
Ensembl chr 4:120,411,991...120,447,455
JBrowse link
G Serpinf1 serpin family F member 1 increases activity EXP cerulein increases activity of Serpinf1 protein in blood RGD PMID:10423332 RGD:1625538 NCBI chr10:62,241,750...62,254,145
Ensembl chr10:62,241,756...62,254,287
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO (+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of STAT3 protein]; [KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of STAT3 protein; IL6 protein inhibits the reaction [(+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of STAT3 protein]] CTD PMID:26390243 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
increases secretion
EXP Ceruletide results in increased expression of TNF mRNA; Ceruletide results in increased expression of TNF protein
2-acetoxy-5-(2-4-(trifluoromethyl)phenethylamino)benzoic acid inhibits the reaction [[Ceruletide co-treated with Lipopolysaccharides] results in increased expression of TNF mRNA]; [Ceruletide co-treated with Lipopolysaccharides] results in increased expression of TNF mRNA; arsenic trioxide inhibits the reaction [Ceruletide results in increased expression of TNF mRNA]; Dietary Fats promotes the reaction [Ceruletide results in increased expression of TNF mRNA]; Dietary Fats promotes the reaction [Ceruletide results in increased secretion of TNF protein]; Pentoxifylline inhibits the reaction [Ceruletide results in increased expression of TNF protein]; Quercetin inhibits the reaction [Ceruletide results in increased expression of TNF mRNA]; Quercetin inhibits the reaction [Dietary Fats promotes the reaction [Ceruletide results in increased expression of TNF mRNA]]
CTD PMID:10773043, PMID:17517186, PMID:22575522, PMID:26873426 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tpi1 triosephosphate isomerase 1 increases expression EXP Ceruletide results in increased expression of TPI1 protein CTD PMID:18024178 NCBI chr 4:157,328,375...157,331,905
Ensembl chr 4:157,328,379...157,331,905
JBrowse link
G Vcp valosin-containing protein decreases expression EXP Ceruletide results in decreased expression of VCP protein CTD PMID:18024178 NCBI chr 5:58,426,548...58,445,953
Ensembl chr 5:58,426,549...58,445,953
JBrowse link
G Xbp1 X-box binding protein 1 increases expression
multiple interactions
EXP Ceruletide results in increased expression of XBP1 mRNA alternative form; Ceruletide results in increased expression of XBP1 protein alternative form
Dietary Fats promotes the reaction [Ceruletide results in increased expression of XBP1 mRNA alternative form]; Dietary Fats promotes the reaction [Ceruletide results in increased expression of XBP1 protein alternative form]; Quercetin inhibits the reaction [Ceruletide results in increased expression of XBP1 mRNA alternative form]; Quercetin inhibits the reaction [Ceruletide results in increased expression of XBP1 protein alternative form]
CTD PMID:26873426 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
G Xiap X-linked inhibitor of apoptosis increases degradation EXP Ceruletide results in increased degradation of XIAP protein CTD PMID:16339139 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link
cisapride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Cisapride results in decreased activity of ABCB11 protein CTD PMID:23956101 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions ISO Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA] CTD PMID:31150804 NCBI chr 8:23,142,733...23,149,067
Ensembl chr 8:23,142,734...23,148,396
JBrowse link
G Ctsk cathepsin K multiple interactions ISO Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA] CTD PMID:31150804 NCBI chr 2:196,655,469...196,666,447
Ensembl chr 2:196,655,469...196,666,446
JBrowse link
G Dcstamp dendrocyte expressed seven transmembrane protein multiple interactions ISO Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA] CTD PMID:31150804 NCBI chr 7:78,642,016...78,651,763
Ensembl chr 7:78,649,875...78,650,906
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA] CTD PMID:31150804 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity
affects localization
affects binding
ISO beta-Cyclodextrins analog inhibits the reaction [Cisapride results in decreased activity of KCNH2 protein]; Cisapride binds to and results in decreased activity of KCNH2 protein; Cisapride inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Cisapride affects the localization of KCNH2 protein mutant form
Cisapride binds to KCNH2 protein
CTD PMID:9395068, PMID:10531299, PMID:11005845, PMID:11741928, PMID:12388285, PMID:15272206, PMID:15306208, PMID:15671647, PMID:15740727, PMID:17513944, PMID:18701618, PMID:19260734, PMID:19583963, PMID:21158687, PMID:24052561, PMID:24830940, PMID:27553911, PMID:28551711, PMID:30561737 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA] CTD PMID:31150804 NCBI chr18:77,203,517...77,322,690
Ensembl chr18:77,203,525...77,322,690
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 increases localization ISO Cisapride results in increased localization of SCN5A protein mutant form CTD PMID:16301357 NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Cisapride inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]; Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA]; Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA] CTD PMID:31150804 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
cyproheptadine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gh1 growth hormone 1 increases expression ISO Cyproheptadine results in increased expression of GH1 protein CTD PMID:642945 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions ISO Cyproheptadine binds to and results in decreased activity of HTR2A protein CTD PMID:17031071 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 affects binding
multiple interactions
ISO Cyproheptadine binds to HTR7 protein
Cyproheptadine inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]
CTD PMID:20827463 NCBI chr 1:254,547,964...254,671,811
Ensembl chr 1:254,547,620...254,671,778
JBrowse link
G Kcnn2 potassium calcium-activated channel subfamily N member 2 decreases activity EXP Cyproheptadine results in decreased activity of KCNN2 protein CTD PMID:10915830 NCBI chr18:39,331,894...39,479,574
Ensembl chr18:39,335,377...39,479,257
JBrowse link
G Pomc proopiomelanocortin decreases secretion ISO Cyproheptadine results in decreased secretion of POMC protein CTD PMID:642945 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Prl prolactin decreases secretion ISO Cyproheptadine results in decreased secretion of PRL protein CTD PMID:642945 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Cyproheptadine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions ISO Cyproheptadine affects the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine] CTD PMID:19821448 NCBI chr10:39,201,101...39,228,090
Ensembl chr10:39,201,107...39,323,853
JBrowse link
devazepide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cckar cholecystokinin A receptor multiple interactions ISO Devazepide inhibits the reaction [CCKAR protein results in increased susceptibility to denatonium] CTD PMID:18003792 NCBI chr14:59,610,939...59,619,786
Ensembl chr14:59,611,434...59,619,783
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Devazepide inhibits the reaction [8-sulfocholecystokinin octapeptide results in increased expression of FOS protein] CTD PMID:9372230 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
eluxadoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Oprd1 opioid receptor, delta 1 affects response to substance ISO OPRD1 protein affects the susceptibility to eluxadoline CTD PMID:25261794 NCBI chr 5:150,288,126...150,323,063
Ensembl chr 5:150,288,126...150,323,063
JBrowse link
kaolin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F11 coagulation factor XI decreases activity ISO Kaolin results in decreased activity of F11 protein CTD PMID:6604052 NCBI chr16:50,179,458...50,201,644
Ensembl chr16:50,179,458...50,201,698
JBrowse link
G F12 coagulation factor XII increases activity ISO Kaolin results in increased activity of F12 protein CTD PMID:6343536 NCBI chr17:9,736,577...9,744,420
Ensembl chr17:9,736,577...9,744,420
JBrowse link
lactulose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions EXP Lactulose inhibits the reaction [Methamphetamine results in increased expression of CASP3 protein modified form] CTD PMID:30450033 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP Lactulose results in increased expression of HMOX1 mRNA CTD PMID:30450033 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Lactulose inhibits the reaction [Methamphetamine results in increased expression of IL1B protein] CTD PMID:30450033 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions EXP Lactulose inhibits the reaction [Methamphetamine results in increased expression of IL6 protein] CTD PMID:30450033 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions EXP Lactulose inhibits the reaction [Methamphetamine results in increased expression of MYD88 protein] CTD PMID:30450033 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP Lactulose promotes the reaction [Methamphetamine results in increased expression of NFE2L2 mRNA] CTD PMID:30450033 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions EXP Lactulose inhibits the reaction [Methamphetamine results in increased expression of PARP1 protein modified form] CTD PMID:30450033 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Lactulose inhibits the reaction [Methamphetamine results in increased expression of RELA protein] CTD PMID:30450033 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP Lactulose promotes the reaction [Methamphetamine results in increased expression of SQSTM1 mRNA] CTD PMID:30450033 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP Lactulose inhibits the reaction [Methamphetamine results in increased expression of TLR4 protein] CTD PMID:30450033 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
Lactulose inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
Lactulose inhibits the reaction [Methamphetamine results in increased expression of TNF protein]
CTD PMID:2311978, PMID:30450033 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions EXP Lactulose inhibits the reaction [Methamphetamine results in increased expression of TRAF6 protein] CTD PMID:30450033 NCBI chr 3:91,252,829...91,271,607
Ensembl chr 3:91,252,829...91,271,607
JBrowse link
loperamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects binding
increases transport
affects response to substance
ISO Loperamide binds to ABCB1 protein
ABCB1 protein results in increased transport of Loperamide
ABCB1A protein affects the susceptibility to Loperamide
CTD PMID:15502009, PMID:23976943 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B affects response to substance ISO ABCB1B protein affects the susceptibility to Loperamide CTD PMID:15502009 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Cat catalase decreases expression EXP Loperamide results in decreased expression of CAT protein CTD PMID:30597669 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ces2h carboxylesterase 2H decreases activity
multiple interactions
ISO Loperamide results in decreased activity of CES2 protein
[Loperamide results in decreased activity of CES2 protein] which results in increased susceptibility to Bisphenol A-Glycidyl Methacrylate
CTD PMID:15687373, PMID:21951919, PMID:28647665 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
JBrowse link
G Ckb creatine kinase B multiple interactions EXP Loperamide results in increased secretion of [CKM protein binds to CKB protein] CTD PMID:30597669 NCBI chr 6:136,142,956...136,145,838
Ensembl chr 6:136,142,956...136,145,837
JBrowse link
G Ckm creatine kinase, M-type multiple interactions EXP Loperamide results in increased secretion of [CKM protein binds to CKB protein] CTD PMID:30597669 NCBI chr 1:80,321,507...80,331,841
Ensembl chr 1:80,321,585...80,331,841
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 increases secretion EXP Loperamide results in increased secretion of GOT1 protein CTD PMID:30597669 NCBI chr 1:263,246,248...263,269,762
Ensembl chr 1:263,246,248...263,269,762
JBrowse link
G Il2 interleukin 2 decreases expression ISO Loperamide results in decreased expression of IL2 mRNA CTD PMID:23965172 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il4 interleukin 4 increases expression ISO Loperamide results in increased expression of IL4 mRNA CTD PMID:23965172 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Loperamide results in increased phosphorylation of MAPK1 protein CTD PMID:23965172 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Loperamide results in increased phosphorylation of MAPK3 protein CTD PMID:23965172 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression ISO Loperamide results in increased expression of NFKBIA protein CTD PMID:22258905 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [Loperamide co-treated with Rifampin] results in increased activity of NR1I2 protein CTD PMID:20869355 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO [Loperamide co-treated with PK 11195] results in decreased activity of NR1I3 protein alternative form; Loperamide binds to and results in decreased activity of NR1I3 protein alternative form CTD PMID:20869355 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Oprd1 opioid receptor, delta 1 affects response to substance ISO OPRD1 protein affects the susceptibility to Loperamide CTD PMID:25261794 NCBI chr 5:150,288,126...150,323,063
Ensembl chr 5:150,288,126...150,323,063
JBrowse link
G Pld2 phospholipase D2 increases activity ISO Loperamide results in increased activity of PLD2 protein CTD PMID:23965172 NCBI chr10:57,161,921...57,181,148
Ensembl chr10:57,163,174...57,179,730
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Loperamide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Tnni3 troponin I3, cardiac type increases secretion EXP Loperamide results in increased secretion of TNNI3 protein CTD PMID:30597669 NCBI chr 1:72,882,806...72,886,490
Ensembl chr 1:72,882,806...72,886,488
JBrowse link
metoclopramide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects response to substance ISO ABCB1A protein affects the susceptibility to Metoclopramide CTD PMID:15502009 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B affects response to substance ISO ABCB1B protein affects the susceptibility to Metoclopramide CTD PMID:15502009 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Ache acetylcholinesterase multiple interactions ISO Metoclopramide binds to and results in decreased activity of ACHE protein; Metoclopramide inhibits the reaction [mipafox binds to and results in decreased activity of ACHE protein]; Metoclopramide inhibits the reaction [mipafox results in decreased activity of ACHE protein]; Metoclopramide inhibits the reaction [Paraoxon binds to and results in decreased activity of ACHE protein]; Metoclopramide inhibits the reaction [Paraoxon results in decreased activity of ACHE protein] CTD PMID:12518340, PMID:14635269, PMID:15052610, PMID:16193528 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 decreases expression ISO Metoclopramide results in decreased expression of ALDH1A2 mRNA CTD PMID:31711903 NCBI chr 8:77,640,234...77,719,488
Ensembl chr 8:77,640,222...77,719,489
JBrowse link
G Amy2a3 amylase 2a3 multiple interactions EXP Metoclopramide inhibits the reaction [Apomorphine results in increased secretion of and results in increased activity of AMY1A protein] CTD PMID:21173550 NCBI chr 2:216,373,674...216,382,260
Ensembl chr 2:216,339,154...216,382,260
JBrowse link
G Ar androgen receptor affects expression
increases expression
multiple interactions
EXP Metoclopramide affects the expression of AR protein
Metoclopramide results in increased expression of AR protein
[Metoclopramide results in decreased abundance of Testosterone] which results in decreased expression of AR protein
CTD PMID:14655152, PMID:16529173, PMID:16584088 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Avp arginine vasopressin multiple interactions ISO Metoclopramide inhibits the reaction [Apomorphine results in increased expression of AVP protein] CTD PMID:16575035 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
JBrowse link
G Bche butyrylcholinesterase multiple interactions ISO Metoclopramide inhibits the reaction [mipafox binds to and results in decreased activity of BCHE protein]; Metoclopramide inhibits the reaction [Paraoxon binds to and results in decreased activity of BCHE protein] CTD PMID:12518340, PMID:15052610 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Metoclopramide inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; Metoclopramide inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; Metoclopramide inhibits the reaction [Malathion results in increased activity of and results in increased cleavage of CASP3 protein]; Metoclopramide inhibits the reaction [Paclitaxel results in increased activity of CASP3 protein]; Metoclopramide inhibits the reaction [Paraoxon results in increased activity of and results in increased cleavage of CASP3 protein]; Metoclopramide inhibits the reaction [TNF protein results in increased activity of CASP3 protein] CTD PMID:29027213 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 multiple interactions
affects binding
EXP [Metoclopramide binds to and results in decreased activity of CHRM3 protein] which results in decreased susceptibility to Carbachol; Metoclopramide inhibits the reaction [4-diphenylacetoxy-N-methylpiperidine methobromide binds to CHRM3 protein]
Metoclopramide binds to CHRM3 protein
CTD PMID:15105209 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO Metoclopramide inhibits the reaction [Indomethacin results in increased expression of CXCL2 mRNA] CTD PMID:21691039 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO Metoclopramide inhibits the reaction [Indomethacin results in increased expression of CXCL1 mRNA] CTD PMID:21691039 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing ISO CYP2D6 gene polymorphism affects the metabolism of Metoclopramide CTD PMID:16702617 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions
affects binding
increases expression
ISO
EXP
Metoclopramide binds to and results in decreased activity of DRD2 protein
Metoclopramide binds to DRD2 protein
Metoclopramide results in increased expression of DRD2 protein
CTD PMID:1930352, PMID:9808703, PMID:11561213, PMID:12130853, PMID:12593651, PMID:17201744, PMID:17303669, PMID:18457824, PMID:21175574 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO [Metoclopramide co-treated with Estradiol] results in decreased expression of ESR1 protein CTD PMID:11786374 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Gcg glucagon increases secretion ISO Metoclopramide results in increased secretion of GCG protein CTD PMID:20829521 NCBI chr 3:48,442,635...48,451,650
Ensembl chr 3:48,442,635...48,451,650
JBrowse link
G Gip gastric inhibitory polypeptide increases secretion ISO Metoclopramide results in increased secretion of GIP protein CTD PMID:20829521 NCBI chr10:83,835,080...83,848,399
Ensembl chr10:83,840,303...83,848,396
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A multiple interactions
affects binding
decreases activity
ISO
EXP
[Dexamethasone co-treated with Metoclopramide] results in decreased activity of HTR3A protein; [Methylprednisolone co-treated with Metoclopramide] results in decreased activity of HTR3A protein; Metoclopramide binds to and results in decreased activity of HTR3A protein; Metoclopramide inhibits the reaction [GR 65630 binds to HTR3A protein]
Metoclopramide binds to HTR3A protein
Metoclopramide results in decreased activity of HTR3A protein
CTD PMID:12130853, PMID:12593651, PMID:15329590, PMID:16041395, PMID:17201744 NCBI chr 8:53,211,436...53,223,878
Ensembl chr 8:53,211,438...53,223,804
JBrowse link
G Ins2 insulin 2 multiple interactions
increases expression
ISO Dopamine promotes the reaction [Metoclopramide results in increased expression of INS protein] CTD PMID:18645345 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Metoclopramide results in decreased activity of KCNH2 protein CTD PMID:15640612 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Lhb luteinizing hormone subunit beta increases expression ISO Metoclopramide results in increased expression of LHB protein CTD PMID:2880862 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Metoclopramide inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:21691039 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Metoclopramide inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA] CTD PMID:21691039 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Metoclopramide inhibits the reaction [Malathion results in increased cleavage of PARP1 protein]; Metoclopramide inhibits the reaction [Paraoxon results in increased cleavage of PARP1 protein] CTD PMID:29027213 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Prl prolactin multiple interactions
increases expression
increases secretion
affects expression
ISO
EXP
Lisuride inhibits the reaction [Metoclopramide results in increased secretion of PRL protein]; Metoclopramide results in increased expression of and results in increased secretion of PRL protein
Metoclopramide results in increased expression of PRL protein
Metoclopramide affects the expression of PRL protein
CTD PMID:386688, PMID:1304515, PMID:1304992, PMID:2635674, PMID:3962302, PMID:7270091, PMID:8803308, PMID:9352036, PMID:11561213, PMID:11786374, PMID:12056626, PMID:14655152, PMID:14870917, PMID:16529173, PMID:16584088, PMID:16815880, PMID:17187127, PMID:17303669, PMID:18978642, PMID:19838586, PMID:20530986 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Prlr prolactin receptor increases expression ISO Metoclopramide results in increased expression of PRLR mRNA; Metoclopramide results in increased expression of PRLR mRNA alternative form CTD PMID:19304288 NCBI chr 2:60,131,410...60,325,686
Ensembl chr 2:60,131,776...60,325,692
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Metoclopramide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 increases expression EXP Metoclopramide results in increased expression of SRD5A1 mRNA CTD PMID:18978642 NCBI chr 1:36,320,504...36,354,694
Ensembl chr 1:36,320,461...36,354,756
JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 increases expression EXP Metoclopramide results in increased expression of SRD5A2 mRNA CTD PMID:18978642 NCBI chr 6:25,279,635...25,315,501
Ensembl chr 6:25,279,626...25,315,511
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Metoclopramide inhibits the reaction [TNF protein results in increased activity of CASP3 protein] CTD PMID:29027213 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
rifaximin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression
ISO [NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of ABCB1A mRNA
rifaximin results in increased expression of ABCB1 mRNA
CTD PMID:21141967, PMID:22790967 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO [NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of ACTA2 mRNA CTD PMID:22790967 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Apoa4 apolipoprotein A4 multiple interactions ISO [NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of APOA4 mRNA CTD PMID:22790967 NCBI chr 8:50,536,983...50,539,371
Ensembl chr 8:50,537,009...50,539,376
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO [rifaximin binds to and results in increased activity of NR1I2 protein] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CCL3 protein]; rifaximin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CCL3 protein] CTD PMID:21599020 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Cd36 CD36 molecule multiple interactions ISO [NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of CD36 protein CTD PMID:22790967 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cfd complement factor D multiple interactions ISO [NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of CFD mRNA CTD PMID:22790967 NCBI chr 7:12,634,216...12,635,939
Ensembl chr 7:12,634,216...12,635,943
JBrowse link
G Cidec cell death-inducing DFFA-like effector c multiple interactions ISO [NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of CIDEC mRNA CTD PMID:22790967 NCBI chr 4:145,377,482...145,390,497
Ensembl chr 4:145,377,431...145,390,497
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO [NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of COL1A1 mRNA CTD PMID:22790967 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions ISO [NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of CYP7A1 protein CTD PMID:22790967 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 multiple interactions ISO [NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of CYP7B1 protein CTD PMID:22790967 NCBI chr 2:102,701,903...102,871,257
Ensembl chr 2:102,701,903...102,871,257
JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 multiple interactions ISO [NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of DGAT2 mRNA CTD PMID:22790967 NCBI chr 1:164,113,459...164,143,818
Ensembl chr 1:164,113,459...164,143,818
JBrowse link
G Fabp2 fatty acid binding protein 2 multiple interactions ISO [NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of FABP2 protein CTD PMID:22790967 NCBI chr 2:227,080,912...227,083,654
Ensembl chr 2:227,080,924...227,083,501
JBrowse link
G Ifng interferon gamma multiple interactions ISO [rifaximin binds to and results in increased activity of NR1I2 protein] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IFNG protein]; rifaximin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IFNG protein] CTD PMID:21599020 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 multiple interactions ISO [rifaximin co-treated with Trinitrobenzenesulfonic Acid] results in increased expression of IL10 protein CTD PMID:21599020 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Lta lymphotoxin alpha multiple interactions ISO [NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of LTA mRNA CTD PMID:22790967 NCBI chr20:4,851,889...4,854,677
Ensembl chr20:4,852,496...4,854,677
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [rifaximin binds to and results in increased activity of NR1I2 protein] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MPO protein]; rifaximin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MPO protein] CTD PMID:21599020 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO [NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of NR1H4 protein CTD PMID:22790967 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
increases expression
increases response to substance
ISO 4,4'-hexafluorisopropylidene diphenol inhibits the reaction [Rifaximin results in increased activity of NR1I2 protein]; 4,4'-hexafluorisopropylidene diphenol metabolite inhibits the reaction [Rifaximin results in increased activity of NR1I2 protein]; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased abundance of Triglycerides; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of ABCB1A mRNA; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of ACTA2 mRNA; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of APOA4 mRNA; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of CD36 protein; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of CFD mRNA; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of CIDEC mRNA; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of COL1A1 mRNA; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of CYP3A11 mRNA; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of CYP7A1 protein; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of CYP7B1 protein; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of DGAT2 mRNA; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of FABP2 protein; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of LTA mRNA; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of NR1H4 protein; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of PPARG mRNA; [Rifaximin binds to and results in increased activity of NR1I2 protein] which results in decreased susceptibility to Trinitrobenzenesulfonic Acid; bis(2-ethylhexyl) 2,3,4,5-tetrabromophthalate inhibits the reaction [Rifaximin results in increased activity of NR1I2 protein]; Rifaximin binds to and results in increased activity of NR1I2 protein
[Rifaximin binds to and results in increased activity of NR1I2 protein] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CCL3 protein]; [Rifaximin binds to and results in increased activity of NR1I2 protein] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IFNG protein]; [Rifaximin binds to and results in increased activity of NR1I2 protein] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MPO protein]; [Rifaximin binds to and results in increased activity of NR1I2 protein] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]
rifaximin results in increased expression of NR1I2 mRNA
NR1I2 results in increased susceptibility to rifaximin
CTD PMID:21599020, PMID:22291955, PMID:22790967, PMID:27506419, PMID:30408883 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO [NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of PPARG mRNA CTD PMID:22790967 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [rifaximin co-treated with Trinitrobenzenesulfonic Acid] results in increased expression of TGFB1 protein CTD PMID:21599020 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [rifaximin binds to and results in increased activity of NR1I2 protein] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]; rifaximin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein] CTD PMID:21599020 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
sulfasalazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadat aminoadipate aminotransferase increases expression ISO Sulfasalazine results in increased expression of AADAT mRNA CTD PMID:22016648 NCBI chr16:32,832,001...32,868,680
Ensembl chr16:32,832,061...32,868,702
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions EXP [Sulfasalazine results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium CTD PMID:19853032 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases transport
increases activity
affects transport
multiple interactions
decreases methylation
ISO ABCG2 protein results in increased transport of Sulfasalazine
Sulfasalazine results in increased activity of ABCG2 protein
ABCG2 gene polymorphism affects the transport of Sulfasalazine
[Sulfasalazine results in decreased methylation of ABCG2 promoter] which results in increased expression of ABCG2 mRNA; Dactinomycin inhibits the reaction [Sulfasalazine results in increased expression of ABCG2 mRNA]; Sulfasalazine inhibits the reaction [[Adenosine Triphosphate co-treated with ABCG2 protein] results in increased uptake of estrone sulfate]; Sulfasalazine promotes the reaction [Cholesterol results in increased activity of ABCG2 protein]
CTD PMID:18167504, PMID:18408567, PMID:20019844, PMID:27475308, PMID:30083819, PMID:32003934 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Acaa1b acetyl-Coenzyme A acyltransferase 1B increases expression ISO Sulfasalazine results in increased expression of ACAA1B mRNA CTD PMID:31830553 NCBI chr 8:127,836,235...127,845,296 JBrowse link
G Acot1 acyl-CoA thioesterase 1 increases expression ISO Sulfasalazine results in increased expression of ACOT1 mRNA CTD PMID:31830553 NCBI chr 6:107,485,088...107,493,082
Ensembl chr 6:107,485,249...107,493,798
JBrowse link
G Acot3 acyl-CoA thioesterase 3 increases expression ISO Sulfasalazine results in increased expression of ACOT3 mRNA CTD PMID:31830553 NCBI chr 6:107,531,508...107,537,446
Ensembl chr 6:107,531,528...107,536,789
JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression ISO Sulfasalazine results in increased expression of ACOX1 mRNA CTD PMID:31830553 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP Sulfasalazine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:15633128 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions
affects localization
ISO BCL2 protein inhibits the reaction [Sulfasalazine affects the localization of AIFM1 protein] CTD PMID:12381674 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases expression ISO Sulfasalazine results in decreased expression of ALDH1A1 mRNA CTD PMID:31830553 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Alpi alkaline phosphatase, intestinal multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of ALPI protein] CTD PMID:15867298 NCBI chr 9:94,197,616...94,201,910
Ensembl chr 9:94,197,618...94,201,084
JBrowse link
G Anxa2 annexin A2 increases expression ISO Sulfasalazine results in increased expression of ANXA2 mRNA CTD PMID:22016648 NCBI chr 8:75,687,134...75,723,589
Ensembl chr 8:75,687,100...75,723,594
JBrowse link
G Apoa4 apolipoprotein A4 decreases expression ISO Sulfasalazine results in decreased expression of APOA4 mRNA CTD PMID:31830553 NCBI chr 8:50,536,983...50,539,371
Ensembl chr 8:50,537,009...50,539,376
JBrowse link
G Azin1 antizyme inhibitor 1 increases expression ISO Sulfasalazine results in increased expression of AZIN1 mRNA CTD PMID:22016648 NCBI chr 7:77,345,646...77,372,398
Ensembl chr 7:77,345,646...77,372,398
JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects localization
multiple interactions
ISO
EXP
Sulfasalazine affects the localization of BAX protein
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BAX protein]
CTD PMID:12381674, PMID:31428839 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO
EXP
BCL2 protein inhibits the reaction [Sulfasalazine affects the localization of AIFM1 protein]
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of BCL2 protein]
CTD PMID:12381674, PMID:31428839 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G C6 complement C6 decreases expression ISO Sulfasalazine results in decreased expression of C6 mRNA CTD PMID:31830553 NCBI chr 2:54,460,333...54,533,801
Ensembl chr 2:54,466,280...54,533,797
JBrowse link
G Casp1 caspase 1 multiple interactions EXP Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of CASP1 protein] CTD PMID:30408459 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO
EXP
Sulfasalazine inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]; Sulfasalazine results in increased cleavage of and results in increased activity of CASP3 protein
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CASP3 protein]
Sulfasalazine results in increased activity of CASP3 protein
CTD PMID:12381674, PMID:16322111, PMID:17051331, PMID:19473188, PMID:19859796, PMID:26165751 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage
ISO Sulfasalazine inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP9 protein]
Sulfasalazine results in increased cleavage of CASP9 protein
CTD PMID:16322111, PMID:19859796 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase increases activity EXP Sulfasalazine results in increased activity of CAT protein CTD PMID:19028562, PMID:19071188 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cav1 caveolin 1 multiple interactions ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CAV1 mRNA]; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CAV1 mRNA CTD PMID:19015640 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CCL2 mRNA] CTD PMID:17449585 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO
EXP
[[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased localization of and results in decreased activity of CTNNB1 protein] which results in decreased expression of CCND1 mRNA
Sulfasalazine results in decreased expression of CCND1 mRNA
CTD PMID:17202759, PMID:19015640 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccng1 cyclin G1 increases expression ISO Sulfasalazine results in increased expression of CCNG1 mRNA CTD PMID:22016648 NCBI chr10:25,903,925...25,910,298
Ensembl chr10:25,903,911...25,910,325
JBrowse link
G Cd14 CD14 molecule multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD14 mRNA CTD PMID:28863153 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
JBrowse link
G Cd19 CD19 molecule multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD19 mRNA CTD PMID:28863153 NCBI chr 1:197,815,422...197,822,123
Ensembl chr 1:197,815,413...197,821,936
JBrowse link
G Cd27 CD27 molecule multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD27 mRNA CTD PMID:28863153 NCBI chr 4:157,744,881...157,751,609
Ensembl chr 4:157,744,882...157,750,088
JBrowse link
G Cd38 CD38 molecule multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD38 mRNA CTD PMID:28863153 NCBI chr14:71,714,768...71,754,990
Ensembl chr14:71,715,269...71,754,672
JBrowse link
G Cd3d CD3d molecule multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD3D mRNA CTD PMID:28863153 NCBI chr 8:49,282,502...49,287,095
Ensembl chr 8:49,282,460...49,287,110
JBrowse link
G Cd46 CD46 molecule decreases expression EXP Sulfasalazine results in decreased expression of CD46 mRNA CTD PMID:15625186 NCBI chr13:113,786,525...113,818,741
Ensembl chr13:113,787,349...113,817,995
JBrowse link
G Cd55 CD55 molecule (Cromer blood group) decreases expression EXP Sulfasalazine results in decreased expression of CD55 mRNA CTD PMID:15625186, PMID:17166698 NCBI chr13:47,125,156...47,153,557
Ensembl chr13:47,126,741...47,154,292
JBrowse link
G Cd59 CD59 molecule decreases expression EXP Sulfasalazine results in decreased expression of CD59 mRNA; Sulfasalazine results in decreased expression of CD59 protein CTD PMID:15625186, PMID:17166698 NCBI chr 3:94,010,481...94,028,660
Ensembl chr 3:94,010,475...94,028,621
JBrowse link
G Cd74 CD74 molecule multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD74 mRNA CTD PMID:28863153 NCBI chr18:56,071,420...56,080,851
Ensembl chr18:56,071,478...56,080,849
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CDH1 mRNA]; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CDH1 mRNA CTD PMID:19015640 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
EXP protoporphyrin IX inhibits the reaction [[Sulfasalazine results in increased expression of HMOX1 protein] which results in increased expression of CDKN1A protein] CTD PMID:19234301 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Clu clusterin increases expression ISO Sulfasalazine results in increased expression of CLU mRNA CTD PMID:22016648 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP Sulfasalazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein] CTD PMID:15633128 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Sulfasalazine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of CSF2 protein] CTD PMID:17051331 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CTLA4 mRNA CTD PMID:28863153 NCBI chr 9:67,699,397...67,706,068
Ensembl chr 9:67,699,379...67,706,065
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO
EXP
[[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased localization of and results in decreased activity of CTNNB1 protein] which results in decreased expression of CCND1 mRNA; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased localization of and results in decreased activity of CTNNB1 protein
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CTNNB1 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CTNNB1 protein]
CTD PMID:19015640, PMID:26165751 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions
affects secretion
ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CXCL1 mRNA; IL1B protein affects the reaction [Sulfasalazine affects the secretion of CXCL1 protein] CTD PMID:12231210, PMID:28863153 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 affects secretion
multiple interactions
ISO Sulfasalazine affects the secretion of CXCL1 protein
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CXCL1 mRNA; IL1B protein affects the reaction [Sulfasalazine affects the secretion of CXCL1 protein]
CTD PMID:12231210, PMID:28863153 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP Sulfasalazine results in increased expression of CYP1A1 mRNA CTD PMID:17202759 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 decreases expression ISO Sulfasalazine results in decreased expression of CYP27B1 mRNA CTD PMID:15243130 NCBI chr 7:70,333,150...70,340,006
Ensembl chr 7:70,335,061...70,340,005
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases expression ISO Sulfasalazine results in increased expression of CYP2A5 mRNA CTD PMID:31830553 NCBI chr 1:83,653,248...83,662,118
Ensembl chr 1:83,653,234...83,766,484
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression ISO Sulfasalazine results in increased expression of CYP2B10 mRNA CTD PMID:31830553 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 increases expression ISO Sulfasalazine results in increased expression of CYP2C55 mRNA; Sulfasalazine results in increased expression of CYP2C55 protein CTD PMID:31830553 NCBI chr 1:258,074,797...258,139,176
Ensembl chr 1:258,074,860...258,139,176
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases expression ISO Sulfasalazine results in increased expression of CYP2C38 mRNA CTD PMID:31830553 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases expression ISO Sulfasalazine results in increased expression of CYP2C29 mRNA CTD PMID:31830553 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Sulfasalazine results in increased expression of DDIT3 mRNA CTD PMID:22016648 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dio1 iodothyronine deiodinase 1 multiple interactions ISO [Sulfasalazine co-treated with pyrazolanthrone] inhibits the reaction [IL1B protein results in decreased expression of DIO1 mRNA] CTD PMID:16614379 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520
JBrowse link
G Dio2 iodothyronine deiodinase 2 multiple interactions ISO
EXP
Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased activity of DIO2 protein]; Sulfasalazine inhibits the reaction [RELA protein promotes the reaction [Lipopolysaccharides results in increased expression of DIO2 mRNA]]
Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased activity of DIO2 protein]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of DIO2 mRNA]
CTD PMID:16728495, PMID:21068073 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723
JBrowse link
G Dnaja2 DnaJ heat shock protein family (Hsp40) member A2 increases expression ISO Sulfasalazine results in increased expression of DNAJA2 mRNA CTD PMID:22016648 NCBI chr19:22,569,999...22,588,143
Ensembl chr19:22,569,999...22,588,137
JBrowse link
G Egf epidermal growth factor increases expression ISO Sulfasalazine results in increased expression of EGF mRNA CTD PMID:22016648 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
decreases expression
ISO [Sulfasalazine co-treated with tripterine] affects the expression of EGFR protein; [Sulfasalazine co-treated with tripterine] results in decreased expression of EGFR protein; geldanamycin promotes the reaction [Sulfasalazine results in decreased expression of EGFR protein]
Sulfasalazine results in decreased expression of EGFR mRNA; Sulfasalazine results in decreased expression of EGFR protein
CTD PMID:20007406, PMID:31830553 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Egr1 early growth response 1 decreases expression ISO Sulfasalazine results in decreased expression of EGR1 mRNA CTD PMID:31830553 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression ISO Sulfasalazine results in increased expression of EPHX1 mRNA CTD PMID:22016648, PMID:31830553 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO Sulfasalazine inhibits the reaction [Heme results in increased expression of F3 mRNA] CTD PMID:18983524 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fabp4 fatty acid binding protein 4 increases expression ISO Sulfasalazine results in increased expression of FABP4 mRNA CTD PMID:22016648 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Fga fibrinogen alpha chain increases expression ISO Sulfasalazine results in increased expression of FGA mRNA CTD PMID:22016648 NCBI chr 2:181,997,562...182,013,726
Ensembl chr 2:182,006,242...182,013,763
JBrowse link
G Fmc1 formation of mitochondrial complex V assembly factor 1 decreases expression ISO Sulfasalazine results in decreased expression of FMC1 mRNA CTD PMID:31830553 NCBI chr 4:66,276,835...66,284,868
Ensembl chr 4:66,276,835...66,284,868
JBrowse link
G Ftl1 ferritin light chain 1 increases expression ISO Sulfasalazine results in increased expression of FTL1 mRNA CTD PMID:22016648 NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
JBrowse link
G G0s2 G0/G1switch 2 increases expression ISO Sulfasalazine results in increased expression of G0S2 mRNA CTD PMID:31830553 NCBI chr13:112,004,140...112,005,052
Ensembl chr13:112,004,140...112,005,052
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta decreases expression EXP Sulfasalazine results in decreased expression of GADD45B mRNA CTD PMID:15633128 NCBI chr 7:11,646,283...11,648,338
Ensembl chr 7:11,646,269...11,648,322
JBrowse link
G Gdnf glial cell derived neurotrophic factor multiple interactions ISO Sulfasalazine inhibits the reaction [rasagiline results in increased expression of GDNF protein] CTD PMID:14687604 NCBI chr 2:56,884,181...56,912,964
Ensembl chr 2:56,887,987...56,910,238
JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression ISO Sulfasalazine results in increased expression of GPT protein CTD PMID:31830553 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gpx3 glutathione peroxidase 3 decreases expression ISO Sulfasalazine results in decreased expression of GPX3 mRNA CTD PMID:31830553 NCBI chr10:40,247,436...40,255,423
Ensembl chr10:40,247,436...40,255,422
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GSK3B protein] CTD PMID:26165751 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity EXP Sulfasalazine results in decreased activity of GSR protein CTD PMID:19028562 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression ISO Sulfasalazine results in increased expression of GSTA1 mRNA; Sulfasalazine results in increased expression of GSTA2 mRNA CTD PMID:31830553 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases expression EXP Sulfasalazine results in increased expression of GSTA5 mRNA CTD PMID:17202759 NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179
JBrowse link
G Gsta6 glutathione S-transferase alpha 6 increases expression ISO Sulfasalazine results in increased expression of GSTA1 mRNA; Sulfasalazine results in increased expression of GSTA2 mRNA CTD PMID:31830553 NCBI chr 9:27,475,273...27,533,939
Ensembl chr 9:27,475,273...27,511,176
JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression ISO Sulfasalazine results in increased expression of GSTM2 mRNA CTD PMID:31830553 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression ISO Sulfasalazine results in increased expression of GSTM3 mRNA CTD PMID:31830553 NCBI chr 2:210,685,338...210,688,133
Ensembl chr 2:210,685,197...210,688,272
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases expression EXP Sulfasalazine results in decreased expression of GSTP1 mRNA CTD PMID:16141653 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hgf hepatocyte growth factor multiple interactions ISO Sulfasalazine inhibits the reaction [HGF protein results in increased expression of MMP9 mRNA] CTD PMID:12745093 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases activity
ISO Sulfasalazine inhibits the reaction [TNF protein results in increased expression of HIF1A protein]
Sulfasalazine results in increased activity of HIF1A protein
CTD PMID:12808024, PMID:19502547 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hint1 histidine triad nucleotide binding protein 1 increases expression ISO Sulfasalazine results in increased expression of HINT1 mRNA CTD PMID:22016648 NCBI chr10:40,208,236...40,211,981
Ensembl chr10:40,208,223...40,211,975
JBrowse link
G Hmgb1 high mobility group box 1 increases expression EXP Sulfasalazine results in increased expression of HMGB1 mRNA CTD PMID:16141653 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Hmox1 heme oxygenase 1 increases response to substance
increases expression
multiple interactions
EXP HMOX1 protein results in increased susceptibility to Sulfasalazine
[Sulfasalazine results in increased expression of HMOX1 protein] which results in increased expression of CDKN1A protein; Sulfasalazine results in increased expression of HMOX1 mRNA; Sulfasalazine results in increased expression of HMOX1 protein
NFE2L2 protein promotes the reaction [Sulfasalazine results in increased expression of HMOX1 mRNA]; NFE2L2 protein promotes the reaction [Sulfasalazine results in increased expression of HMOX1 protein]; protoporphyrin IX inhibits the reaction [[Sulfasalazine results in increased expression of HMOX1 protein] which results in increased expression of CDKN1A protein]; Sulfasalazine promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]
CTD PMID:19234301 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 decreases expression EXP Sulfasalazine results in decreased expression of HSD17B3 mRNA CTD PMID:29197623 NCBI chr17:1,579,319...1,610,745
Ensembl chr17:1,579,319...1,610,745
JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 increases expression ISO Sulfasalazine results in increased expression of HSD17B4 mRNA CTD PMID:22016648 NCBI chr18:44,810,462...44,897,677
Ensembl chr18:44,810,388...44,897,640
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression EXP Sulfasalazine results in decreased expression of HSD3B1 mRNA CTD PMID:29197623
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 increases expression ISO Sulfasalazine results in increased expression of HSP90AB1 mRNA CTD PMID:22016648 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO Sulfasalazine results in increased expression of HSPA1A mRNA CTD PMID:22016648 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B decreases expression EXP Sulfasalazine results in decreased expression of HSPA1B mRNA CTD PMID:16141653 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression
multiple interactions
increases expression
ISO
EXP
Sulfasalazine results in decreased expression of ICAM1 mRNA; Sulfasalazine results in decreased expression of ICAM1 protein
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ICAM1 protein]
Sulfasalazine inhibits the reaction [RELA protein binds to ICAM1 promoter]
Sulfasalazine results in increased expression of ICAM1 protein
CTD PMID:11264155, PMID:15553846, PMID:17259377, PMID:20823682, PMID:26165751, PMID:31428839 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Idh3b isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta increases expression ISO Sulfasalazine results in increased expression of IDH3B mRNA CTD PMID:22016648 NCBI chr 3:122,808,564...122,813,638
Ensembl chr 3:122,808,564...122,813,583
JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 multiple interactions ISO Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of IDO1 mRNA] CTD PMID:20884048 NCBI chr16:72,216,326...72,228,098
Ensembl chr16:72,216,326...72,228,098
JBrowse link
G Ifng interferon gamma multiple interactions ISO [Sulfasalazine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA; Sulfasalazine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IFNG protein]; Sulfasalazine inhibits the reaction [IFNG protein results in increased activity of TYMP protein]; Sulfasalazine inhibits the reaction [IFNG protein results in increased expression of CXCL8 protein]
Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of [IL12B protein binds to IL12A protein]]; Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein]; Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of IFNG protein]
CTD PMID:11529938, PMID:15269287, PMID:17051331, PMID:25231984, PMID:29594315, PMID:32272095 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 affects expression EXP Sulfasalazine affects the expression of IGFBP3 mRNA CTD PMID:16141653 NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta decreases expression ISO Sulfasalazine results in decreased expression of IKBKB protein CTD PMID:15564333 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Il10 interleukin 10 multiple interactions ISO
EXP
Sulfasalazine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IL10 protein]
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL10 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL10 protein]; Sulfasalazine promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL10 protein]
Sulfasalazine inhibits the reaction [Dextran Sulfate results in decreased expression of IL10 protein]
CTD PMID:15604057, PMID:17051331, PMID:25231984, PMID:25727887, PMID:29731490 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il10ra interleukin 10 receptor subunit alpha multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of IL10RA mRNA CTD PMID:28863153 NCBI chr 8:49,558,062...49,573,891
Ensembl chr 8:49,560,035...49,573,742
JBrowse link
G Il12a interleukin 12A multiple interactions ISO Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of [IL12B protein binds to IL12A protein]] CTD PMID:11529938 NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318
JBrowse link
G Il12b interleukin 12B multiple interactions ISO Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of [IL12B protein binds to IL12A protein]]; Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein] CTD PMID:11529938 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il17a interleukin 17A multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL17A protein] CTD PMID:31428839 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
ISO
EXP
[Sulfasalazine co-treated with pyrazolanthrone] inhibits the reaction [IL1B protein results in decreased expression of DIO1 mRNA]; IL1B protein affects the reaction [Sulfasalazine affects the secretion of CXCL1 protein]; IL1B protein affects the reaction [Sulfasalazine affects the secretion of CXCL8 protein]; Sulfasalazine inhibits the reaction [IL1B protein results in decreased expression of THRB mRNA]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
[allicin co-treated with Sulfasalazine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; [allicin co-treated with Sulfasalazine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]; Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of IL1B protein]; Sulfasalazine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]
Sulfasalazine results in decreased expression of IL1B mRNA
IL1B protein inhibits the reaction [[Sulfasalazine co-treated with pyrazolanthrone] results in decreased expression of THRA mRNA]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]; Sulfasalazine promotes the reaction [IL1B protein results in decreased expression of THRA mRNA alternative form]; Sulfasalazine promotes the reaction [IL1B protein results in decreased expression of THRA mRNA]
CTD PMID:12133438, PMID:12231210, PMID:15604057, PMID:15793857, PMID:15867298, PMID:15955209, PMID:16614379, PMID:17375077, PMID:17449585, PMID:17641275, PMID:19956958, PMID:20884048, PMID:22119283, PMID:25231984, PMID:25576893, PMID:25727887, PMID:25729217, PMID:26165751, PMID:29594315, PMID:29731490, PMID:30408459, PMID:32272095 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1r1 interleukin 1 receptor type 1 multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1R1 mRNA] CTD PMID:17449585 NCBI chr 9:46,962,291...47,038,139
Ensembl chr 9:46,962,288...47,036,670
JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1RN mRNA] CTD PMID:15867298 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Sulfasalazine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA; Sulfasalazine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IL2 protein]
Sulfasalazine inhibits the reaction [Dextran Sulfate results in decreased expression of IL2 protein]
CTD PMID:17051331, PMID:29594315, PMID:32272095 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha multiple interactions ISO Sulfasalazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL2RA protein] CTD PMID:7815356 NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071
JBrowse link
G Il4 interleukin 4 multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased secretion of IL4 protein] CTD PMID:25729217 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
Sulfasalazine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IL6 protein]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
Sulfasalazine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein]
Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of and results in increased secretion of IL6 protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein]
CTD PMID:12135912, PMID:17051331, PMID:19956958, PMID:20884048, PMID:21070844, PMID:25231984, PMID:25576893, PMID:26102009, PMID:29731490, PMID:31428839, PMID:32272095 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Insr insulin receptor increases expression ISO Sulfasalazine results in increased expression of INSR protein CTD PMID:15564333 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
JBrowse link
G Irf4 interferon regulatory factor 4 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of IRF4 mRNA CTD PMID:28863153 NCBI chr17:34,886,746...34,905,191
Ensembl chr17:34,886,739...34,905,117
JBrowse link
G Irs2 insulin receptor substrate 2 decreases expression ISO Sulfasalazine results in decreased expression of IRS2 mRNA CTD PMID:31830553 NCBI chr16:83,824,515...83,848,569
Ensembl chr16:83,824,430...83,848,684
JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO Sulfasalazine inhibits the reaction [TNF protein results in increased expression of ITGAM protein] CTD PMID:8094364 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Itgb2 integrin subunit beta 2 multiple interactions ISO Sulfasalazine inhibits the reaction [TNF protein results in increased expression of ITGB2 protein] CTD PMID:8094364 NCBI chr20:11,777,773...11,815,647
Ensembl chr20:11,777,783...11,815,647
JBrowse link
G Itk IL2-inducible T-cell kinase multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of ITK mRNA CTD PMID:28863153 NCBI chr10:31,431,820...31,493,413
Ensembl chr10:31,431,809...31,493,419
JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of JAK2 protein] CTD PMID:32272095 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Jchain joining chain of multimeric IgA and IgM multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of JCHAIN mRNA CTD PMID:28863153 NCBI chr14:21,176,841...21,183,731
Ensembl chr14:21,177,237...21,183,542
JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of LCK mRNA CTD PMID:28863153 NCBI chr 5:147,750,976...147,779,627
Ensembl chr 5:147,750,973...147,761,983
JBrowse link
G Lsm10 LSM10, U7 small nuclear RNA associated decreases expression ISO Sulfasalazine results in decreased expression of LSM10 mRNA CTD PMID:31830553 NCBI chr 5:144,106,339...144,108,703
Ensembl chr 5:144,106,802...144,108,708
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation EXP Sulfasalazine results in increased phosphorylation of MAPK9 protein CTD PMID:15633128 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mill1 MHC I like leukocyte 1 decreases expression ISO Sulfasalazine results in decreased expression of MICA mRNA; Sulfasalazine results in decreased expression of MICA protein CTD PMID:15494508 NCBI chr 1:79,631,266...79,657,943
Ensembl chr 1:79,631,668...79,657,941
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of MMP1 mRNA CTD PMID:28863153 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP Sulfasalazine promotes the reaction [Carbon Tetrachloride results in increased activity of MMP2 protein] CTD PMID:15633128 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO
EXP
Sulfasalazine inhibits the reaction [HGF protein results in increased expression of MMP9 mRNA]; Sulfasalazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MMP9 protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of and results in increased cleavage of MMP9 protein]
CTD PMID:12745093, PMID:22119283 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpo myeloperoxidase multiple interactions
decreases activity
EXP
ISO
Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]; Sulfasalazine inhibits the reaction [Dinitrochlorobenzene results in decreased activity of MPO protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MPO protein]
Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of MPO protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]
Sulfasalazine results in decreased activity of MPO protein
CTD PMID:17373747, PMID:20380826, PMID:22119283, PMID:23665423, PMID:25231984, PMID:25576893, PMID:26102009, PMID:26165751, PMID:31428839 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mr1 major histocompatibility complex, class I-related affects expression ISO Sulfasalazine affects the expression of MR1 mRNA CTD PMID:25811541 NCBI chr13:72,771,992...72,789,861
Ensembl chr13:72,771,984...72,789,841
JBrowse link
G Ms4a1 membrane spanning 4-domains A1 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of MS4A1 mRNA CTD PMID:28863153 NCBI chr 1:227,429,241...227,441,492
Ensembl chr 1:227,429,596...227,441,442
JBrowse link
G Mthfr methylenetetrahydrofolate reductase increases response to substance ISO MTHFR gene polymorphism results in increased susceptibility to Sulfasalazine; MTHFR protein results in increased susceptibility to Sulfasalazine CTD PMID:19578646 NCBI chr 5:164,844,642...164,864,360
Ensembl chr 5:164,845,925...164,860,910
JBrowse link
G Muc2 mucin 2, oligomeric mucus/gel-forming multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MUC2 mRNA] CTD PMID:17449585 NCBI chr 1:214,663,929...214,693,197 JBrowse link
G Muc3 mucin 3, intestinal multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MUC3 mRNA] CTD PMID:17449585 NCBI chr12:22,535,663...22,584,775 JBrowse link
G Muc4 mucin 4, cell surface associated multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MUC4 mRNA] CTD PMID:17449585 NCBI chr11:71,242,973...71,285,217
Ensembl chr11:71,243,334...71,284,939
JBrowse link
G Nat2 N-acetyltransferase 2 affects metabolic processing
increases acetylation
increases metabolic processing
affects response to substance
ISO NAT2 gene polymorphism affects the metabolism of Sulfasalazine; NAT2 protein affects the metabolism of Sulfasalazine; NAT2 protein polymorphism affects the metabolism of Sulfasalazine
NAT2 protein results in increased acetylation of Sulfasalazine
NAT2 protein results in increased metabolism of Sulfasalazine
NAT2 protein affects the susceptibility to Sulfasalazine
CTD PMID:12465141, PMID:15032315, PMID:17377643, PMID:17502830, PMID:19560446 NCBI chr16:23,960,709...23,991,570
Ensembl chr16:23,961,067...23,991,570
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO
EXP
[Sulfasalazine results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased localization of NFE2L2 protein; Acetylcysteine inhibits the reaction [[Sulfasalazine results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased localization of NFE2L2 protein]
NFE2L2 protein promotes the reaction [Sulfasalazine results in increased expression of HMOX1 mRNA]; NFE2L2 protein promotes the reaction [Sulfasalazine results in increased expression of HMOX1 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of NFE2L2 mRNA]; Sulfasalazine promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]
CTD PMID:19234301, PMID:31428839 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
decreases localization
decreases expression
ISO
EXP
Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased activity of NFKB1 protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NFKB1 protein]
Sulfasalazine results in decreased localization of NFKB1 protein
Sulfasalazine results in decreased expression of NFKB1 protein
CTD PMID:9486988, PMID:12135912, PMID:15269287, PMID:17259377, PMID:26165751 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
decreases phosphorylation
decreases expression
increases degradation
ISO
EXP
Sulfasalazine inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
Sulfasalazine results in decreased phosphorylation of NFKBIA protein
Sulfasalazine inhibits the reaction [Glucose results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased degradation of NFKBIA protein]
Sulfasalazine results in decreased expression of NFKBIA protein
Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of NFKBIA protein]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]
Sulfasalazine results in increased degradation of NFKBIA protein
CTD PMID:9486988, PMID:11786414, PMID:15494508, PMID:15793857, PMID:16934226, PMID:17051331, PMID:19365232, PMID:20823682, PMID:22245600, PMID:32272095 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of NLRP3 mRNA] CTD PMID:30408459 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression
ISO
EXP
Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
Sulfasalazine results in decreased expression of NOS2 mRNA
Sulfasalazine affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 protein]; Sulfasalazine inhibits the reaction [Gentamicins results in increased expression of NOS2 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of NOS2 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 protein]
CTD PMID:11529938, PMID:15867298, PMID:16925772, PMID:16934226, PMID:17259377, PMID:17375077, PMID:20712904, PMID:31428839 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP
ISO
Sulfasalazine results in increased expression of NQO1 mRNA CTD PMID:19234301, PMID:22016648 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases expression ISO Sulfasalazine results in increased expression of NR3C1 mRNA; Sulfasalazine results in increased expression of NR3C1 protein CTD PMID:17267514 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Oat ornithine aminotransferase increases expression ISO Sulfasalazine results in increased expression of OAT mRNA CTD PMID:22016648 NCBI chr 1:204,562,289...204,582,070
Ensembl chr 1:204,562,289...204,582,070
JBrowse link
G Odc1 ornithine decarboxylase 1 increases expression ISO Sulfasalazine results in increased expression of ODC1 mRNA CTD PMID:22016648 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions ISO Sulfasalazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of OPRM1 mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of OPRM1 mRNA] CTD PMID:11901219 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO Sulfasalazine results in increased expression of PCNA mRNA CTD PMID:22016648 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pgam2 phosphoglycerate mutase 2 increases expression ISO Sulfasalazine results in increased expression of PGAM2 mRNA CTD PMID:22016648 NCBI chr14:86,045,005...86,047,116
Ensembl chr14:86,044,969...86,047,162
JBrowse link
G Pla2g1b phospholipase A2 group IB multiple interactions ISO Sulfasalazine inhibits the reaction [PLA2G1B protein results in increased expression of CXCL8 protein] CTD PMID:15528384 NCBI chr12:46,879,346...46,890,234
Ensembl chr12:46,879,343...46,889,082
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
multiple interactions
EXP
ISO
Sulfasalazine results in increased expression of PPARG mRNA
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of PPARG mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of PPARG protein]
CTD PMID:19365232, PMID:26165751, PMID:31830553 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Prdm1 PR/SET domain 1 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of PRDM1 mRNA CTD PMID:28863153 NCBI chr20:49,464,921...49,556,623
Ensembl chr20:49,464,919...49,556,518
JBrowse link
G Prdx1 peroxiredoxin 1 increases expression EXP
ISO
Sulfasalazine results in increased expression of PRDX1 mRNA CTD PMID:16141653, PMID:22016648 NCBI chr 5:135,536,413...135,551,986
Ensembl chr 5:135,536,413...135,551,990
JBrowse link
G Prdx3 peroxiredoxin 3 increases expression ISO Sulfasalazine results in increased expression of PRDX3 mRNA CTD PMID:22016648 NCBI chr 1:282,238,774...282,251,193
Ensembl chr 1:282,238,773...282,251,257
JBrowse link
G Psmb9 proteasome 20S subunit beta 9 decreases expression EXP Sulfasalazine results in decreased expression of PSMB9 mRNA CTD PMID:17202759 NCBI chr20:3,973,424...3,978,845
Ensembl chr20:3,973,420...3,978,845
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions
EXP
ISO
Sulfasalazine results in decreased expression of PTGS2 mRNA
Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of PTGS2 protein]
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 protein]
CTD PMID:17259377, PMID:19956958, PMID:25576893, PMID:30408459 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptpmt1 protein tyrosine phosphatase, mitochondrial 1 increases expression ISO Sulfasalazine results in increased expression of PTPMT1 mRNA CTD PMID:22016648 NCBI chr 3:79,734,961...79,743,737
Ensembl chr 3:79,734,961...79,743,737
JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of RASGRP1 mRNA CTD PMID:28863153 NCBI chr 3:108,984,029...109,044,420
Ensembl chr 3:108,984,029...109,044,420
JBrowse link
G Rbp4 retinol binding protein 4 affects expression ISO Sulfasalazine affects the expression of RBP4 mRNA CTD PMID:22016648 NCBI chr 1:256,806,476...256,813,678
Ensembl chr 1:256,806,472...256,813,711
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases localization
affects localization
increases localization
decreases activity
ISO
EXP
Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]; Sulfasalazine inhibits the reaction [rasagiline results in increased localization of and results in increased activity of RELA protein]; Sulfasalazine inhibits the reaction [RELA protein promotes the reaction [Lipopolysaccharides results in increased expression of DIO2 mRNA]]; Sulfasalazine inhibits the reaction [TNF protein results in increased activity of RELA protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased localization of and results in increased activity of RELA protein]; Sulfasalazine results in decreased expression of and results in decreased activity of RELA protein; Sulfasalazine results in decreased phosphorylation of and results in decreased activity of RELA protein
Sulfasalazine results in decreased localization of RELA protein
Sulfasalazine inhibits the reaction [Gentamicins results in increased expression of RELA protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of RELA mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of RELA protein]
Sulfasalazine affects the localization of RELA protein
Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of RELA protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of RELA protein]; Sulfasalazine inhibits the reaction [RELA protein binds to ICAM1 promoter]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of RELA protein]
Sulfasalazine results in increased localization of RELA protein
Sulfasalazine results in decreased activity of RELA protein
CTD PMID:9486988, PMID:12135912, PMID:14687604, PMID:15269287, PMID:15564333, PMID:15955209, PMID:16626516, PMID:16728495, PMID:16925772, PMID:17259377, PMID:18089796, PMID:19956958, PMID:20823682, PMID:21070844, PMID:26102009, PMID:32272095 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rgs16 regulator of G-protein signaling 16 increases expression ISO Sulfasalazine results in increased expression of RGS16 mRNA CTD PMID:31830553 NCBI chr13:71,163,411...71,185,147
Ensembl chr13:71,179,910...71,185,216
JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 multiple interactions ISO Sulfasalazine inhibits the reaction [TNF protein results in increased expression of RIPK2 mRNA] CTD PMID:19693652 NCBI chr 5:29,838,713...29,870,390
Ensembl chr 5:29,838,747...29,870,735
JBrowse link
G Rnf186 ring finger protein 186 decreases expression ISO Sulfasalazine results in decreased expression of RNF186 mRNA CTD PMID:31830553 NCBI chr 5:157,416,897...157,418,121
Ensembl chr 5:157,416,897...157,418,121
JBrowse link
G RT1-Bb RT1 class II, locus Bb affects expression EXP Sulfasalazine affects the expression of RT1-BB mRNA CTD PMID:17202759 NCBI chr20:4,043,726...4,049,367
Ensembl chr20:4,039,413...4,049,711
JBrowse link
G Sdc1 syndecan 1 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of SDC1 mRNA CTD PMID:28863153 NCBI chr 6:33,885,576...33,908,038
Ensembl chr 6:33,885,495...33,908,016
JBrowse link
G Sele selectin E increases expression ISO Sulfasalazine results in increased expression of SELE protein CTD PMID:11264155 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Serpina4 serpin family A member 4 decreases expression ISO Sulfasalazine results in decreased expression of SERPINA4-PS1 mRNA CTD PMID:31830553 NCBI chr 6:127,743,883...127,753,047
Ensembl chr 6:127,743,971...127,753,046
JBrowse link
G Serpinc1 serpin family C member 1 increases expression ISO Sulfasalazine results in increased expression of SERPINC1 mRNA CTD PMID:22016648 NCBI chr13:78,806,107...78,820,375
Ensembl chr13:78,805,347...78,833,192
JBrowse link
G Sik1 salt-inducible kinase 1 decreases expression ISO Sulfasalazine results in decreased expression of SIK1 mRNA CTD PMID:31830553 NCBI chr20:10,670,747...10,680,279
Ensembl chr20:10,668,411...10,680,283
JBrowse link
G Slamf7 SLAM family member 7 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of SLAMF7 mRNA CTD PMID:28863153 NCBI chr13:90,056,726...90,075,159
Ensembl chr13:90,058,127...90,075,144
JBrowse link
G Slc22a7 solute carrier family 22 member 7 decreases expression ISO Sulfasalazine results in decreased expression of SLC22A7 mRNA CTD PMID:31830553 NCBI chr 9:16,925,321...16,931,119
Ensembl chr 9:16,924,520...16,931,766
JBrowse link
G Slc25a24 solute carrier family 25 member 24 decreases expression ISO Sulfasalazine results in decreased expression of SLC25A24 mRNA CTD PMID:31830553 NCBI chr 2:211,930,371...211,967,511
Ensembl chr 2:211,930,326...211,967,505
JBrowse link
G Slc25a5 solute carrier family 25 member 5 increases expression ISO Sulfasalazine results in increased expression of SLC25A6 mRNA CTD PMID:22016648 NCBI chr  X:123,404,570...123,407,637
Ensembl chr  X:123,404,518...123,407,645
JBrowse link
G Slc30a1 solute carrier family 30 member 1 decreases expression ISO Sulfasalazine results in decreased expression of SLC30A1 mRNA CTD PMID:31830553 NCBI chr13:110,677,810...110,681,683
Ensembl chr13:110,677,810...110,681,683
JBrowse link
G Slc3a2 solute carrier family 3 member 2 multiple interactions ISO Sulfasalazine inhibits the reaction [[SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine] CTD PMID:19576933 NCBI chr 1:224,906,566...224,921,029
Ensembl chr 1:224,906,554...224,921,092
JBrowse link
G Slc46a1 solute carrier family 46 member 1 multiple interactions
decreases activity
ISO
EXP
Sulfasalazine inhibits the reaction [SLC46A1 protein results in increased transport of Methotrexate]
Sulfasalazine results in decreased activity of SLC46A1 protein
Sulfasalazine inhibits the reaction [SLC46A1 protein results in increased transport of Folic Acid]
CTD PMID:17475902, PMID:18174275, PMID:19762432 NCBI chr10:65,728,508...65,741,708
Ensembl chr10:65,733,991...65,740,828
JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases activity
multiple interactions
ISO Sulfasalazine results in decreased activity of SLC7A11 protein
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CAV1 mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CDH1 mRNA]; [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased abundance of Glutathione] which results in increased abundance of Reactive Oxygen Species; [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased localization of and results in decreased activity of CTNNB1 protein] which results in decreased expression of CCND1 mRNA; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased abundance of Glutathione; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased localization of and results in decreased activity of CTNNB1 protein; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CAV1 mRNA; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CDH1 mRNA; Sulfasalazine inhibits the reaction [[SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine]
CTD PMID:19015640, PMID:19576933, PMID:20007406 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Socs2 suppressor of cytokine signaling 2 decreases expression ISO Sulfasalazine results in decreased expression of SOCS2 mRNA CTD PMID:31830553 NCBI chr 7:36,495,496...36,500,878
Ensembl chr 7:36,495,480...36,499,784
JBrowse link
G Sod1 superoxide dismutase 1 increases expression ISO Sulfasalazine results in increased expression of SOD1 mRNA CTD PMID:22016648 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod3 superoxide dismutase 3 decreases expression ISO Sulfasalazine results in decreased expression of SOD3 mRNA CTD PMID:31830553 NCBI chr14:60,958,583...60,971,143
Ensembl chr14:60,958,592...60,964,324
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO Sulfasalazine results in increased expression of SPP1 mRNA CTD PMID:22016648 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Star steroidogenic acute regulatory protein decreases expression
affects expression
EXP Sulfasalazine results in decreased expression of STAR protein
Sulfasalazine affects the expression of STAR mRNA
CTD PMID:29197623 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of STAT3 protein] CTD PMID:32272095 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tbxas1 thromboxane A synthase 1 multiple interactions
decreases activity
ISO [Sulfasalazine results in decreased activity of TBXAS1 protein] which results in decreased chemical synthesis of 12-hydroxy-5,8,10-heptadecatrienoic acid; [Sulfasalazine results in decreased activity of TBXAS1 protein] which results in decreased chemical synthesis of Thromboxane B2 CTD PMID:2572437 NCBI chr 4:66,624,181...66,846,745
Ensembl chr 4:66,670,618...66,846,805
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase multiple interactions ISO Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of TDO2 mRNA] CTD PMID:20884048 NCBI chr 2:180,897,059...180,914,919
Ensembl chr 2:180,897,011...180,914,940
JBrowse link
G Tff3 trefoil factor 3 multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TFF3 mRNA] CTD PMID:17449585 NCBI chr20:9,850,800...9,855,481
Ensembl chr20:9,850,803...9,855,481
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions
decreases expression
ISO [Sulfasalazine co-treated with pyrazolanthrone] results in decreased expression of THRA mRNA; IL1B protein inhibits the reaction [[Sulfasalazine co-treated with pyrazolanthrone] results in decreased expression of THRA mRNA]; Sulfasalazine promotes the reaction [IL1B protein results in decreased expression of THRA mRNA alternative form]; Sulfasalazine promotes the reaction [IL1B protein results in decreased expression of THRA mRNA]
Sulfasalazine results in decreased expression of THRA mRNA; Sulfasalazine results in decreased expression of THRA mRNA alternative form
CTD PMID:17641275 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO Sulfasalazine inhibits the reaction [IL1B protein results in decreased expression of THRB mRNA] CTD PMID:16614379 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP Sulfasalazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 protein] CTD PMID:15633128 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO Sulfasalazine results in increased expression of TIMP2 mRNA CTD PMID:22016648 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072
JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 increases expression ISO Sulfasalazine results in increased expression of TIMP3 mRNA CTD PMID:22016648 NCBI chr 7:23,543,125...23,594,170
Ensembl chr 7:23,544,215...23,594,133
JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions ISO Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 mRNA] CTD PMID:12888452 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of TLR4 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TLR4 protein] CTD PMID:19956958, PMID:32272095 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases secretion
decreases expression
increases response to substance
ISO
EXP
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of TNF mRNA; Sulfasalazine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of TNF protein]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased activity of RELA protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased activity of TYMP protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of HIF1A protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of ITGAM protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of ITGB2 protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of OPRM1 mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of RIPK2 mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased localization of and results in increased activity of RELA protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Sulfasalazine promotes the reaction [Ganciclovir results in increased secretion of TNF protein]
Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of and results in increased secretion of TNF protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]
Sulfasalazine results in decreased secretion of TNF protein
Sulfasalazine results in decreased expression of TNF mRNA
[allicin co-treated with Sulfasalazine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]; Sulfasalazine binds to and results in decreased activity of TNF protein; Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of TNF protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; Sulfasalazine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased secretion of TNF protein]
Sulfasalazine results in increased susceptibility to TNF protein
CTD PMID:8094364, PMID:8598465, PMID:9486988, PMID:11901219, PMID:12135912, PMID:12745093, PMID:12808024, PMID:15269287, PMID:17051331, PMID:17143539, PMID:17449585, PMID:19693652, PMID:19956958, PMID:20712904, PMID:20884048, PMID:21070844, PMID:22119283, PMID:23665423, PMID:25231984, PMID:25576893, PMID:25727887, PMID:25729217, PMID:26102009, PMID:28863153, PMID:29731490, PMID:30408459, PMID:32272095 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases secretion ISO Sulfasalazine results in increased secretion of TNFRSF11B protein CTD PMID:15593184 NCBI chr 7:93,798,580...93,826,586
Ensembl chr 7:93,798,545...93,826,665
JBrowse link
G Tnfrsf17 TNF receptor superfamily member 17 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of TNFRSF17 mRNA CTD PMID:28863153 NCBI chr10:4,252,097...4,258,335
Ensembl chr10:4,251,941...4,257,868
JBrowse link
G Tnfsf11 TNF superfamily member 11 decreases expression ISO Sulfasalazine results in decreased expression of TNFSF11 mRNA; Sulfasalazine results in decreased expression of TNFSF11 protein CTD PMID:15593184 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
G Tpm3 tropomyosin 3 decreases expression ISO Sulfasalazine results in decreased expression of TPM3 mRNA alternative form; Sulfasalazine results in decreased expression of TPM3 protein alternative form CTD PMID:19369484 NCBI chr 2:189,423,534...189,451,340
Ensembl chr 2:189,423,559...189,451,029
JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of TRAF6 protein] CTD PMID:32272095 NCBI chr 3:91,252,829...91,271,607
Ensembl chr 3:91,252,829...91,271,607
JBrowse link
G Tshb thyroid stimulating hormone subunit beta increases secretion ISO Sulfasalazine results in increased secretion of TSHB protein CTD PMID:12587019 NCBI chr 2:205,207,799...205,215,199
Ensembl chr 2:205,207,799...205,212,681
JBrowse link
G Tubb5 tubulin, beta 5 class I increases expression ISO Sulfasalazine results in increased expression of TUBB5 mRNA CTD PMID:22016648 NCBI chr20:3,422,448...3,426,420
Ensembl chr20:3,422,461...3,426,371
JBrowse link
G Tymp thymidine phosphorylase multiple interactions
decreases expression
ISO Sulfasalazine inhibits the reaction [IFNG protein results in increased activity of TYMP protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased activity of TYMP protein]; Sulfasalazine results in decreased expression of and results in decreased activity of TYMP protein
Sulfasalazine results in decreased expression of TYMP mRNA
CTD PMID:15269287 NCBI chr 7:130,342,481...130,347,845
Ensembl chr 7:130,342,483...130,347,587
JBrowse link
G Ubc ubiquitin C increases expression ISO Sulfasalazine results in increased expression of UBC mRNA CTD PMID:22016648 NCBI chr12:36,638,457...36,642,734
Ensembl chr12:36,638,457...36,642,734
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions
decreases expression
increases expression
ISO
EXP
Sulfasalazine inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]
Sulfasalazine results in decreased expression of VCAM1 mRNA
Sulfasalazine results in increased expression of VCAM1 protein
Sulfasalazine results in decreased expression of VCAM1 mRNA; Sulfasalazine results in decreased expression of VCAM1 protein
CTD PMID:11264155, PMID:15553846, PMID:17259377, PMID:19693652 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vim vimentin increases expression ISO Sulfasalazine results in increased expression of VIM mRNA CTD PMID:22016648 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of XBP1 mRNA CTD PMID:28863153 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
tectochrysin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 decreases activity ISO tectochrysin results in decreased activity of ABCG2 protein CTD PMID:15930306 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
tegaserod term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO tegaserod results in decreased activity of CYP1A2 protein CTD PMID:11560869 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing
decreases activity
multiple interactions
ISO CYP2D6 protein results in increased metabolism of tegaserod
tegaserod results in decreased activity of CYP2D6 protein
Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of tegaserod]
CTD PMID:11560869 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO tegaserod binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Htr4 5-hydroxytryptamine receptor 4 multiple interactions ISO tegaserod binds to and results in increased activity of HTR4 protein CTD PMID:15238200, PMID:15961989 NCBI chr18:57,637,013...57,820,317
Ensembl chr18:57,654,290...57,819,698
JBrowse link
G Pgr progesterone receptor multiple interactions ISO tegaserod binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO tegaserod binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      application 19426
        pharmaceutical 19301
          drug 19301
            gastrointestinal drug 316
              16,16-dimethylprostaglandin E2 8
              3,7,12-trioxo-5beta-cholanic acid 1
              alosetron + 0
              alpha-methylene gamma-butyrolactone + 0
              antidiarrhoeal drug + 21
              auraptene 24
              balsalazide + 1
              balsalazide disodium 0
              betazole + 0
              betazole dihydrochloride 0
              ceruletide + 50
              ceruletide diethylamine 0
              cisapride 10
              cyproheptadine + 8
              cyproheptadine hydrochloride sesquihydrate 0
              devazepide 2
              eluxadoline 1
              lactulose 12
              metoclopramide 30
              metoclopramide dihydrochloride monohydrate 0
              metoclopramide hydrochloride + 0
              proglumide + 0
              rifaximin 21
              sofalcone 0
              sulfasalazine 197
              tegaserod + 6
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.