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ONTOLOGY REPORT - ANNOTATIONS


Term:granisetron
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Accession:CHEBI:5537 term browser browse the term
Definition:A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 1-methyl-1H-indazole-3-carboxylic acid with the primary amino group of (3-endo)-9-methyl-9-azabicyclo[3.3.1]nonan-3-amine. A selective 5-HT3 receptor antagonist, it is used (generally as the monohydrochloride salt) to manage nausea and vomiting caused by cancer chemotherapy and radiotherapy, and to prevent and treat postoperative nausea and vomiting.
Synonyms:exact_synonym: 1-methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide
 related_synonym: 1-methyl-N-(9-methyl-endo-9-azabicyclo(3.3.1)non-3-yl)-1H-indazole-3-carboxamide;   APF 530;   APF530;   BRL 43694;   Formula=C18H24N4O;   InChI=1S/C18H24N4O/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23)/t12-,13+,14-;   InChIKey=MFWNKCLOYSRHCJ-BTTYYORXSA-N;   Kevatril;   SMILES=CN1[C@H]2CCC[C@@H]1C[C@@H](C2)NC(=O)c1nn(C)c2ccccc12;   Sancuso;   Sustol;   granisetronum
 xref: CAS:109889-09-0 "ChemIDplus";   CAS:109889-09-0 "KEGG COMPOUND";   DrugBank:DB00889;   Drug_Central:1329 "DrugCentral";   HMDB:HMDB0015026;   KEGG:C07023;   KEGG:D04370
 xref_mesh: MESH:D017829
 xref: PDBeChem:CWB;   PMID:1650335 "Europe PMC";   PMID:2169778 "Europe PMC";   PMID:22452942 "Europe PMC";   PMID:24388937 "Europe PMC";   PMID:2540014 "Europe PMC";   PMID:25834466 "Europe PMC";   PMID:25866983 "Europe PMC";   PMID:26289588 "Europe PMC";   PMID:26812081 "Europe PMC";   PMID:26925101 "Europe PMC";   PMID:26997579 "Europe PMC";   PMID:27073822 "Europe PMC";   PMID:27129842 "Europe PMC";   PMID:27162748 "Europe PMC";   PMID:27184113 "Europe PMC";   PMID:27186139 "Europe PMC";   PMID:27358385 "Europe PMC";   PMID:27382819 "Europe PMC";   PMID:27400689 "Europe PMC";   PMID:27571447 "Europe PMC";   PMID:27650869 "Europe PMC";   PMID:27703112 "Europe PMC";   PMID:27746523 "Europe PMC";   PMID:27809336 "Europe PMC";   PMID:27895421 "Europe PMC";   PMID:27915445 "Europe PMC";   PMID:28002447 "Europe PMC";   PMID:28061543 "Europe PMC";   PMID:28168082 "Europe PMC";   PMID:28211304 "Europe PMC";   Patent:EP200444;   Patent:US4886808;   Reaxys:3655275 "Reaxys";   Wikipedia:Granisetron


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granisetron term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adra1a adrenoceptor alpha 1A JBrowse link 15 43,296,997 43,398,314 RGD:6480464
G Amy2a3 amylase 2a3 JBrowse link 2 216,373,674 216,382,260 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Slc22a2 solute carrier family 22 member 2 JBrowse link 1 48,318,025 48,360,219 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19728
    role 19675
      application 19328
        pharmaceutical 19202
          drug 19202
            antiemetic 5091
              granisetron 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    p-block element atom 19610
                      carbon group element atom 19501
                        carbon atom 19494
                          organic molecular entity 19494
                            organic group 18413
                              organic divalent group 18404
                                organodiyl group 18404
                                  carbonyl group 18293
                                    carbonyl compound 18293
                                      carboxylic acid 17960
                                        carboacyl group 17072
                                          univalent carboacyl group 17072
                                            carbamoyl group 16801
                                              carboxamide 16801
                                                monocarboxylic acid amide 14163
                                                  granisetron 4
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