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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hexachlorobenzene
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Accession:CHEBI:5692 term browser browse the term
Definition:A member of the class of chlorobenzenes that is benzene in which all of the hydrogens are replaced by chlorines. An agricultural fungicide introduced in the mid-1940s and formerly used as a seed treatment, its use has been banned since 1984 under the Stockholm Convention on Persistent Organic Pollutants.
Synonyms:related_synonym: 1,2,3,4,5,6-hexachlorobenzene;   Formula=C6Cl6;   HCB;   Hexachlorbenzol;   InChI=1S/C6Cl6/c7-1-2(8)4(10)6(12)5(11)3(1)9;   InChIKey=CKAPSXZOOQJIBF-UHFFFAOYSA-N;   SMILES=Clc1c(Cl)c(Cl)c(Cl)c(Cl)c1Cl;   perchlorobenzene;   phenyl perchloryl
 xref: Beilstein:1912585;   CAS:118-74-1;   Gmelin:27278;   HMDB:HMDB0032566;   KEGG:C11042
 xref_mesh: MESH:D006581
 xref: PMID:10641019;   PMID:12117784;   PMID:17150971;   PMID:23336922;   PMID:23462309;   PMID:23627767;   PMID:23747559;   PMID:23923419;   PMID:23973543;   PMID:24148401;   PMID:24311623;   PMID:24365113;   PPDB:380;   Reaxys:1912585;   Wikipedia:Hexachlorobenzene


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hexachlorobenzene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP Hexachlorobenzene results in increased expression of ABCC3 mRNA CTD PMID:23153324 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Ackr2 atypical chemokine receptor 2 increases expression EXP Hexachlorobenzene results in increased expression of ACKR2 mRNA CTD PMID:15159207 NCBI chr 8:130,526,521...130,543,566
Ensembl chr 8:130,538,651...130,542,227
JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression ISO Hexachlorobenzene results in increased expression of ACTA2 protein CTD PMID:28923513 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Agtr1a angiotensin II receptor, type 1a increases expression EXP Hexachlorobenzene results in increased expression of AGTR1 protein CTD PMID:29277037 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
affects localization
decreases expression
affects expression
increases expression
affects binding
increases localization
ISO
EXP
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Hexachlorobenzene results in decreased expression of AHR mRNA]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK1 protein]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to Hexachlorobenzene; [Phenanthrolines binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK1 protein]; [Phenanthrolines binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [Phenanthrolines binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein]; [Phenanthrolines binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to Hexachlorobenzene; Hexachlorobenzene binds to and results in increased activity of AHR protein; Hexachlorobenzene results in decreased expression of and affects the localization of AHR protein
Hexachlorobenzene affects the localization of AHR protein
Hexachlorobenzene results in decreased expression of AHR protein
Hexachlorobenzene affects the expression of AHR mRNA
Hexachlorobenzene affects the reaction [AHR protein affects the expression of CYP1A1 mRNA]; Hexachlorobenzene affects the reaction [AHR protein affects the expression of EGFR mRNA]; Hexachlorobenzene affects the reaction [AHR protein affects the expression of IGF1 mRNA]; Hexachlorobenzene affects the reaction [AHR protein affects the expression of TGFB1 mRNA]; Hexachlorobenzene affects the reaction [AHR protein affects the expression of TGFBR2 mRNA]
Hexachlorobenzene results in increased expression of AHR protein
Hexachlorobenzene binds to AHR protein
[Diethylnitrosamine co-treated with Hexachlorobenzene] results in increased expression of AHR protein; Hexachlorobenzene inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]
Hexachlorobenzene results in increased localization of AHR protein
CTD PMID:2539049, PMID:9407059, PMID:15515957, PMID:16705413, PMID:18295415, PMID:21205633, PMID:26219504, PMID:26358519, PMID:27519288, PMID:28923513, PMID:29277037 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Aif1 allograft inflammatory factor 1 affects expression EXP Hexachlorobenzene affects the expression of AIF1 mRNA CTD PMID:15159207 NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions
affects localization
EXP 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Hexachlorobenzene affects the localization of AIFM1 protein]; Reactive Oxygen Species promotes the reaction [Hexachlorobenzene affects the localization of AIFM1 protein] CTD PMID:23708402 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP AKT1 protein promotes the reaction [Hexachlorobenzene results in decreased expression of GJB1 mRNA]; AKT1 protein promotes the reaction [Hexachlorobenzene results in decreased expression of GJB1 protein]; Hexachlorobenzene results in increased activity of and results in increased localization of AKT1 protein CTD PMID:16679308, PMID:17150971 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions EXP [Hexachlorobenzene co-treated with Methylnitrosourea] results in increased phosphorylation of AKT2 protein CTD PMID:22245120 NCBI chr 1:84,400,939...84,451,223
Ensembl chr 1:84,411,726...84,450,162
JBrowse link
G Alad aminolevulinate dehydratase affects expression EXP Hexachlorobenzene affects the expression of ALAD mRNA CTD PMID:15159207 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Alas2 5'-aminolevulinate synthase 2 increases expression EXP Hexachlorobenzene results in increased expression of ALAS2 mRNA CTD PMID:15159207 NCBI chr  X:23,167,576...23,187,356
Ensembl chr  X:23,167,696...23,187,341
JBrowse link
G Alox15 arachidonate 15-lipoxygenase increases expression EXP Hexachlorobenzene results in increased expression of ALOX15 mRNA CTD PMID:15159207 NCBI chr10:56,953,692...56,962,145
Ensembl chr10:56,953,691...56,962,161
JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein affects expression EXP Hexachlorobenzene affects the expression of ALOX5AP mRNA CTD PMID:15159207 NCBI chr12:6,854,930...6,879,112
Ensembl chr12:6,854,920...6,879,154
JBrowse link
G Anxa1 annexin A1 increases expression EXP Hexachlorobenzene results in increased expression of ANXA1 mRNA CTD PMID:15159207 NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012
JBrowse link
G Bid BH3 interacting domain death agonist decreases expression EXP Hexachlorobenzene results in decreased expression of BID protein CTD PMID:21787832 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G C1qb complement C1q B chain increases expression EXP Hexachlorobenzene results in increased expression of C1QB mRNA CTD PMID:15159207 NCBI chr 5:155,246,444...155,251,995
Ensembl chr 5:155,246,447...155,252,003
JBrowse link
G C1s complement C1s increases expression EXP Hexachlorobenzene results in increased expression of C1S mRNA CTD PMID:15159207 NCBI chr 4:157,143,592...157,155,592
Ensembl chr 4:157,143,592...157,155,609
JBrowse link
G C4bpa complement component 4 binding protein, alpha increases expression EXP Hexachlorobenzene results in increased expression of C4BPA mRNA CTD PMID:15159207 NCBI chr13:47,342,090...47,377,580
Ensembl chr13:47,342,079...47,377,703
JBrowse link
G Capg capping actin protein, gelsolin like increases expression EXP Hexachlorobenzene results in increased expression of CAPG mRNA CTD PMID:15159207 NCBI chr 4:100,395,693...100,419,447
Ensembl chr 4:100,407,658...100,419,446
JBrowse link
G Casp1 caspase 1 affects expression EXP Hexachlorobenzene affects the expression of CASP1 mRNA CTD PMID:15159207 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp3 caspase 3 increases expression
increases activity
multiple interactions
EXP Hexachlorobenzene results in increased expression of CASP3 mRNA
Hexachlorobenzene results in increased activity of CASP3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hexachlorobenzene results in increased activity of CASP3 protein]
CTD PMID:19815060, PMID:21787832, PMID:23708402 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases activity EXP Hexachlorobenzene results in increased activity of CASP8 protein CTD PMID:21787832, PMID:23708402 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
EXP Hexachlorobenzene results in increased cleavage of and results in increased activity of CASP9 protein
Hexachlorobenzene results in increased activity of CASP9 protein
CTD PMID:19182106, PMID:21787832 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase increases expression EXP Hexachlorobenzene results in increased expression of CAT mRNA CTD PMID:15159207 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression EXP Hexachlorobenzene results in increased expression of CCL20 mRNA CTD PMID:15159207 NCBI chr 9:88,918,359...88,921,017
Ensembl chr 9:88,918,433...88,921,001
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hexachlorobenzene results in increased expression of CCND1 protein] CTD PMID:26219504, PMID:28215542 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccne1 cyclin E1 multiple interactions ISO Hexachlorobenzene promotes the reaction [CDK2 protein binds to CCNE1 protein]; Hexachlorobenzene promotes the reaction [CDKN1B protein binds to CCNE1 protein] CTD PMID:28215542 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Cd14 CD14 molecule increases expression EXP Hexachlorobenzene results in increased expression of CD14 mRNA CTD PMID:15159207 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
JBrowse link
G Cd24 CD24 molecule affects expression EXP Hexachlorobenzene affects the expression of CD24 mRNA CTD PMID:15159207 NCBI chr20:48,335,540...48,340,847
Ensembl chr20:48,335,540...48,340,846
JBrowse link
G Cd247 Cd247 molecule decreases expression EXP Hexachlorobenzene results in decreased expression of CD3Z mRNA CTD PMID:15159207 NCBI chr13:83,996,045...84,071,408
Ensembl chr13:83,996,080...84,071,400
JBrowse link
G Cd36 CD36 molecule increases expression EXP Hexachlorobenzene results in increased expression of CD36 mRNA CTD PMID:15159207 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cd37 CD37 molecule decreases expression EXP Hexachlorobenzene results in decreased expression of CD37 mRNA CTD PMID:15159207 NCBI chr 1:101,230,470...101,236,061
Ensembl chr 1:101,230,533...101,236,065
JBrowse link
G Cd3d CD3d molecule decreases expression EXP Hexachlorobenzene results in decreased expression of CD3D mRNA CTD PMID:15159207 NCBI chr 8:49,282,502...49,287,095
Ensembl chr 8:49,282,460...49,287,110
JBrowse link
G Cd48 Cd48 molecule affects expression EXP Hexachlorobenzene affects the expression of CD48 mRNA CTD PMID:15159207 NCBI chr13:90,116,601...90,140,371
Ensembl chr13:90,116,843...90,140,371
JBrowse link
G Cd5 Cd5 molecule affects expression EXP Hexachlorobenzene affects the expression of CD5 mRNA CTD PMID:15159207 NCBI chr 1:226,770,912...226,791,861
Ensembl chr 1:226,770,744...226,791,879
JBrowse link
G Cd52 CD52 molecule increases expression EXP Hexachlorobenzene results in increased expression of CD52 mRNA CTD PMID:15159207 NCBI chr 5:152,322,910...152,324,469
Ensembl chr 5:152,322,916...152,324,469
JBrowse link
G Cd59 CD59 molecule increases expression EXP Hexachlorobenzene results in increased expression of CD59 mRNA CTD PMID:15159207 NCBI chr 3:94,010,481...94,028,660
Ensembl chr 3:94,010,475...94,028,621
JBrowse link
G Cd63 Cd63 molecule increases expression EXP Hexachlorobenzene results in increased expression of CD63 mRNA CTD PMID:15159207 NCBI chr 7:3,320,250...3,335,583
Ensembl chr 7:3,320,103...3,335,582
JBrowse link
G Cd74 CD74 molecule decreases expression EXP Hexachlorobenzene results in decreased expression of CD74 mRNA CTD PMID:15159207 NCBI chr18:56,071,420...56,080,851
Ensembl chr18:56,071,478...56,080,849
JBrowse link
G Cd9 CD9 molecule increases expression EXP Hexachlorobenzene results in increased expression of CD9 mRNA CTD PMID:15159207 NCBI chr 4:157,977,163...158,010,091
Ensembl chr 4:157,977,162...158,010,166
JBrowse link
G Cdh1 cadherin 1 multiple interactions EXP [Hexachlorobenzene results in decreased activity of GSK3B protein] which results in decreased expression of CDH1 protein CTD PMID:16679308 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO Hexachlorobenzene promotes the reaction [CDK2 protein binds to CCNE1 protein] CTD PMID:28215542 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression
multiple interactions
EXP
ISO
Hexachlorobenzene results in increased expression of CDKN1B protein
Hexachlorobenzene affects the reaction [CDKN1B protein binds to SRC protein]; Hexachlorobenzene promotes the reaction [CDKN1B protein binds to CCNE1 protein]
CTD PMID:25093615, PMID:28215542 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases methylation EXP Hexachlorobenzene results in increased methylation of CDKN2A promoter alternative form CTD PMID:26431795 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Cish cytokine inducible SH2-containing protein increases expression EXP Hexachlorobenzene results in increased expression of CISH mRNA CTD PMID:15159207 NCBI chr 8:116,054,547...116,059,494
Ensembl chr 8:116,054,465...116,060,723
JBrowse link
G Clec4f C-type lectin domain family 4, member F increases expression EXP Hexachlorobenzene results in increased expression of CLEC4F mRNA CTD PMID:15159207 NCBI chr 4:115,322,300...115,332,021
Ensembl chr 4:115,322,291...115,332,052
JBrowse link
G Cma1 chymase 1 increases expression EXP Hexachlorobenzene results in increased expression of CMA1 mRNA CTD PMID:15159207 NCBI chr15:34,601,037...34,603,819
Ensembl chr15:34,601,037...34,603,819
JBrowse link
G Comt catechol-O-methyltransferase increases expression ISO Hexachlorobenzene results in increased expression of COMT protein CTD PMID:24365113 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Cp ceruloplasmin increases expression EXP Hexachlorobenzene results in increased expression of CP mRNA CTD PMID:15159207 NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853
JBrowse link
G Cpa3 carboxypeptidase A3 increases expression EXP Hexachlorobenzene results in increased expression of CPA3 mRNA CTD PMID:15159207 NCBI chr 2:105,016,798...105,047,989
Ensembl chr 2:105,016,626...105,047,984
JBrowse link
G Csf2rb colony stimulating factor 2 receptor subunit beta increases expression EXP Hexachlorobenzene results in increased expression of CSF2RB mRNA CTD PMID:15159207 NCBI chr 7:119,554,383...119,568,248
Ensembl chr 7:119,554,354...119,568,776
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression EXP Hexachlorobenzene results in increased expression of CXCL1 mRNA CTD PMID:15159207 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 affects expression EXP Hexachlorobenzene affects the expression of CXCL10 mRNA CTD PMID:15159207 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression EXP Hexachlorobenzene results in increased expression of CXCR4 mRNA CTD PMID:15159207 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 increases expression ISO Hexachlorobenzene results in increased expression of CYP11A1 protein CTD PMID:24365113 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
EXP
ISO
Hexachlorobenzene results in increased expression of CYP1A1 mRNA; Hexachlorobenzene results in increased expression of CYP1A1 protein
Hexachlorobenzene affects the reaction [AHR protein affects the expression of CYP1A1 mRNA]
Hexachlorobenzene results in increased expression of and results in increased activity of CYP1A1 protein
CTD PMID:2539049, PMID:2845946, PMID:2856071, PMID:15159207, PMID:17202759, PMID:19879930, PMID:24365113, PMID:27519288, PMID:28923513 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression EXP Hexachlorobenzene results in increased expression of CYP1A2 mRNA; Hexachlorobenzene results in increased expression of CYP1A2 protein CTD PMID:2539049, PMID:2845946, PMID:2856071, PMID:9630449, PMID:10696772 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression EXP Hexachlorobenzene results in increased expression of CYP1B1 mRNA CTD PMID:15159207 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases expression EXP Hexachlorobenzene results in increased expression of CYP2A3 mRNA CTD PMID:15159207 NCBI chr 1:83,653,248...83,662,118
Ensembl chr 1:83,653,234...83,766,484
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP Hexachlorobenzene results in increased expression of CYP2B1 protein CTD PMID:10696772 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression
increases expression
EXP Hexachlorobenzene results in decreased expression of CYP2E1 mRNA
Hexachlorobenzene results in increased expression of CYP2E1 protein
CTD PMID:10696772, PMID:15159207 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression EXP Hexachlorobenzene results in increased expression of CYP3A2 mRNA CTD PMID:15159207 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 affects expression EXP Hexachlorobenzene affects the expression of CYP3A23-3A1 mRNA CTD PMID:15159207 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp4a8 cytochrome P450, family 4, subfamily a, polypeptide 8 increases expression EXP Hexachlorobenzene results in increased expression of CYP4A8 mRNA CTD PMID:15159207 NCBI chr 5:133,978,953...134,008,255
Ensembl chr 5:133,978,954...134,008,255
JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 increases expression EXP Hexachlorobenzene results in increased expression of CYP7B1 mRNA CTD PMID:15159207 NCBI chr 2:102,701,903...102,871,257
Ensembl chr 2:102,701,903...102,871,257
JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases activity
increases activity
EXP Hexachlorobenzene results in decreased activity of DIO1 protein
Hexachlorobenzene results in increased activity of DIO1 protein
CTD PMID:15664263 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520
JBrowse link
G Dio2 iodothyronine deiodinase 2 decreases expression EXP Hexachlorobenzene results in decreased expression of DIO2 mRNA CTD PMID:29277037 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
increases expression
increases phosphorylation
ISO
EXP
[AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of EGFR protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK1 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein]; [RTKI cpd results in decreased activity of EGFR protein] which results in decreased susceptibility to Hexachlorobenzene; Hexachlorobenzene results in increased phosphorylation of and results in increased expression of EGFR protein
Hexachlorobenzene results in increased expression of EGFR mRNA
Hexachlorobenzene affects the reaction [AHR protein affects the expression of EGFR mRNA]
AG 1879 inhibits the reaction [SRC protein promotes the reaction [Hexachlorobenzene results in increased phosphorylation of EGFR protein]]; Hexachlorobenzene promotes the reaction [EGFR protein binds to SRC protein]; Hexachlorobenzene promotes the reaction [Methylnitrosourea promotes the reaction [EGFR protein binds to SRC protein]]; Hexachlorobenzene promotes the reaction [Methylnitrosourea results in increased phosphorylation of EGFR protein]; Hexachlorobenzene results in increased phosphorylation of and results in decreased expression of EGFR protein; Methylnitrosourea promotes the reaction [Hexachlorobenzene promotes the reaction [EGFR protein binds to SRC protein]]; Methylnitrosourea promotes the reaction [Hexachlorobenzene results in increased phosphorylation of EGFR protein]; SRC protein promotes the reaction [Hexachlorobenzene results in increased phosphorylation of EGFR protein]
CTD PMID:18295415, PMID:21205633, PMID:22245120, PMID:23462309, PMID:28923513 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Emb embigin increases expression EXP Hexachlorobenzene results in increased expression of EMB mRNA CTD PMID:15159207 NCBI chr 2:49,682,763...49,733,475
Ensembl chr 2:49,682,754...49,732,253
JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression EXP Hexachlorobenzene results in increased expression of EPHX1 mRNA CTD PMID:15159207 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Ephx2 epoxide hydrolase 2 decreases expression EXP Hexachlorobenzene results in decreased expression of EPHX2 mRNA CTD PMID:15159207 NCBI chr15:42,757,241...42,794,211
Ensembl chr15:42,757,235...42,794,279
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
decreases expression
increases expression
increases phosphorylation
ISO
EXP
ESR1 protein affects the reaction [[Hydrocarbons, Chlorinated co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased secretion of IGF1 protein]; Fulvestrant promotes the reaction [Hexachlorobenzene results in decreased expression of ESR1 protein]
Hexachlorobenzene results in increased expression of ESR1 protein
Hexachlorobenzene promotes the reaction [ESR1 protein binds to SRC protein]; Hexachlorobenzene promotes the reaction [Methylnitrosourea results in decreased phosphorylation of ESR1 protein]; Methylnitrosourea inhibits the reaction [Hexachlorobenzene promotes the reaction [ESR1 protein binds to SRC protein]]
Hexachlorobenzene results in increased phosphorylation of ESR1 protein
CTD PMID:19879930, PMID:22245120, PMID:28923513, PMID:29277037, PMID:31923581 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Fas Fas cell surface death receptor increases expression EXP Hexachlorobenzene results in increased expression of FAS protein CTD PMID:21787832 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand increases expression EXP Hexachlorobenzene results in increased expression of FASLG protein CTD PMID:21787832 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fcer1a Fc fragment of IgE receptor Ia increases expression EXP Hexachlorobenzene results in increased expression of FCER1A mRNA CTD PMID:15159207 NCBI chr13:91,727,253...91,737,106
Ensembl chr13:91,730,925...91,737,053
JBrowse link
G Fcer2 Fc fragment of IgE receptor II decreases expression EXP Hexachlorobenzene results in decreased expression of FCER2A mRNA CTD PMID:15159207 NCBI chr12:2,233,772...2,245,324
Ensembl chr12:2,233,778...2,245,324
JBrowse link
G Fcgr2a Fc fragment of IgG receptor IIa increases expression EXP Hexachlorobenzene results in increased expression of FCGR3 mRNA CTD PMID:15159207 NCBI chr13:91,146,878...91,163,691
Ensembl chr13:91,168,973...91,198,036
Ensembl chr13:91,168,973...91,198,036
JBrowse link
G Fcgrt Fc fragment of IgG receptor and transporter increases expression EXP Hexachlorobenzene results in increased expression of FCGRT mRNA CTD PMID:15159207 NCBI chr 1:101,086,872...101,096,159
Ensembl chr 1:101,086,877...101,095,594
JBrowse link
G Fn1 fibronectin 1 increases expression EXP Hexachlorobenzene results in increased expression of FN1 mRNA CTD PMID:15159207 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Hexachlorobenzene results in increased expression of FOS protein CTD PMID:9630449, PMID:10696772 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions
decreases expression
EXP Hexachlorobenzene inhibits the reaction [Methylnitrosourea results in decreased expression of FSHB protein]
Hexachlorobenzene results in decreased expression of FSHB protein
CTD PMID:22245120 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression EXP Hexachlorobenzene results in increased expression of GCLM mRNA CTD PMID:15159207 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gjb1 gap junction protein, beta 1 multiple interactions
decreases expression
EXP AKT1 protein promotes the reaction [Hexachlorobenzene results in decreased expression of GJB1 mRNA]; AKT1 protein promotes the reaction [Hexachlorobenzene results in decreased expression of GJB1 protein]; Estradiol affects the reaction [Hexachlorobenzene results in increased expression of GJB1 mRNA]
Hexachlorobenzene results in decreased expression of GJB1 mRNA; Hexachlorobenzene results in decreased expression of GJB1 protein
CTD PMID:12117784, PMID:17150971 NCBI chr  X:71,272,030...71,279,973
Ensembl chr  X:71,272,042...71,279,977
JBrowse link
G Gjb2 gap junction protein, beta 2 decreases expression EXP Hexachlorobenzene results in decreased expression of GJB2 mRNA; Hexachlorobenzene results in decreased expression of GJB2 protein CTD PMID:12117784 NCBI chr15:37,377,313...37,394,494
Ensembl chr15:37,377,316...37,383,277
JBrowse link
G Glg1 golgi glycoprotein 1 affects expression EXP Hexachlorobenzene affects the expression of GLG1 mRNA CTD PMID:15159207 NCBI chr19:42,983,879...43,088,074
Ensembl chr19:42,983,869...43,090,841
JBrowse link
G Gpx3 glutathione peroxidase 3 affects expression EXP Hexachlorobenzene affects the expression of GPX3 mRNA CTD PMID:15159207 NCBI chr10:40,247,436...40,255,423
Ensembl chr10:40,247,436...40,255,422
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases activity
multiple interactions
EXP Hexachlorobenzene results in decreased activity of GSK3B protein
[Hexachlorobenzene results in decreased activity of GSK3B protein] which results in decreased expression of CDH1 protein
CTD PMID:16679308 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 affects expression
increases expression
EXP Hexachlorobenzene affects the expression of GSTA2 mRNA
Hexachlorobenzene results in increased expression of GSTA3 mRNA
CTD PMID:15159207 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases expression EXP Hexachlorobenzene results in decreased expression of GSTM1 mRNA CTD PMID:15159207 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression EXP Hexachlorobenzene results in increased expression of GSTM2 mRNA CTD PMID:15159207 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression EXP Hexachlorobenzene results in increased expression of GSTP1 protein CTD PMID:9630449, PMID:10696772 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G H2ax H2A.X variant histone increases expression ISO Hexachlorobenzene results in increased expression of H2AX protein CTD PMID:32156659 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hdc histidine decarboxylase increases expression EXP Hexachlorobenzene results in increased expression of HDC mRNA CTD PMID:15159207 NCBI chr 3:119,057,524...119,075,599
Ensembl chr 3:119,057,517...119,075,619
JBrowse link
G Hmbs hydroxymethylbilane synthase increases expression
increases activity
EXP Hexachlorobenzene results in increased expression of HMBS mRNA
Hexachlorobenzene increases activity of Hmbs protein in liver
CTD PMID:15159207, PMID:1781034 RGD:25440495 NCBI chr 8:48,667,278...48,674,673
Ensembl chr 8:48,667,275...48,674,748
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
affects expression
EXP Hexachlorobenzene results in increased expression of HMOX1 mRNA
Hexachlorobenzene affects the expression of HMOX1 mRNA
CTD PMID:15159207, PMID:22954530 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hp haptoglobin increases expression EXP Hexachlorobenzene results in increased expression of HP mRNA CTD PMID:15159207 NCBI chr19:42,096,255...42,100,805
Ensembl chr19:42,097,995...42,100,804
JBrowse link
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 decreases expression EXP Hexachlorobenzene results in decreased expression of HSD17B2 mRNA CTD PMID:15159207 NCBI chr19:50,246,404...50,317,892
Ensembl chr19:50,246,402...50,317,891
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 decreases expression EXP Hexachlorobenzene results in decreased expression of HSP90AB1 mRNA CTD PMID:15159207 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 increases expression EXP Hexachlorobenzene results in increased expression of HSPE1 mRNA CTD PMID:15159207 NCBI chr 9:61,691,246...61,724,948
Ensembl chr 9:61,692,154...61,694,599
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression EXP Hexachlorobenzene results in increased expression of ICAM1 mRNA CTD PMID:15159207 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma affects expression
decreases expression
increases expression
EXP
ISO
Hexachlorobenzene affects the expression of IFNG mRNA
Hexachlorobenzene results in decreased expression of IFNG protein
Hexachlorobenzene results in increased expression of IFNG mRNA
CTD PMID:9465272, PMID:11119253, PMID:11266329, PMID:15319175 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igf1 insulin-like growth factor 1 affects expression
increases secretion
multiple interactions
ISO Hexachlorobenzene affects the expression of IGF1 mRNA
Hexachlorobenzene results in increased secretion of IGF1 protein
1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [[Hydrocarbons, Chlorinated co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased expression of IGF1 mRNA]; 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [[Hydrocarbons, Chlorinated co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased secretion of IGF1 protein]; [Hydrocarbons, Chlorinated co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased expression of and results in increased secretion of IGF1 protein; [Hydrocarbons, Chlorinated co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased expression of IGF1 mRNA; ESR1 protein affects the reaction [[Hydrocarbons, Chlorinated co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased secretion of IGF1 protein]
Hexachlorobenzene affects the reaction [AHR protein affects the expression of IGF1 mRNA]
CTD PMID:28923513, PMID:31923581 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igf1r insulin-like growth factor 1 receptor increases expression
multiple interactions
EXP
ISO
Hexachlorobenzene results in increased expression of IGF1R protein
[Hexachlorobenzene co-treated with Estradiol] results in increased expression of IGF1R protein; fulvestrant inhibits the reaction [[Hexachlorobenzene co-treated with Estradiol] results in increased expression of IGF1R protein]; fulvestrant inhibits the reaction [Hexachlorobenzene results in increased expression of IGF1R protein]
Hexachlorobenzene inhibits the reaction [Methylnitrosourea results in increased expression of IGF1R protein]
CTD PMID:16237195, PMID:19879930 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 multiple interactions ISO [Hydrocarbons, Chlorinated co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] affects the expression of IGFBP2 mRNA CTD PMID:31923581 NCBI chr 9:80,118,029...80,144,804
Ensembl chr 9:80,118,029...80,144,789
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 multiple interactions ISO [Hydrocarbons, Chlorinated co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] affects the expression of IGFBP3 mRNA CTD PMID:31923581 NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374
JBrowse link
G IgG-2a gamma-2a immunoglobulin heavy chain increases expression EXP Hexachlorobenzene results in increased expression of IGG-2A mRNA CTD PMID:15159207
G Igsf6 immunoglobulin superfamily, member 6 affects expression EXP Hexachlorobenzene affects the expression of IGSF6 mRNA CTD PMID:15159207 NCBI chr 1:190,997,029...191,007,503
Ensembl chr 1:190,997,029...191,007,503
JBrowse link
G Il10 interleukin 10 affects expression
decreases expression
EXP
ISO
Hexachlorobenzene affects the expression of IL10 mRNA; Hexachlorobenzene affects the expression of IL10 protein
Hexachlorobenzene results in decreased expression of IL10 protein
CTD PMID:11119253, PMID:15319175 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il15 interleukin 15 decreases expression EXP Hexachlorobenzene results in decreased expression of IL15 mRNA CTD PMID:15159207 NCBI chr19:23,542,606...23,624,366
Ensembl chr19:23,542,889...23,554,594
JBrowse link
G Il18 interleukin 18 increases expression EXP Hexachlorobenzene results in increased expression of IL18 mRNA CTD PMID:15159207 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1b interleukin 1 beta affects expression EXP Hexachlorobenzene affects the expression of IL1B mRNA CTD PMID:15159207 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 increases expression EXP Hexachlorobenzene results in increased expression of IL2 mRNA CTD PMID:9465272 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha increases expression EXP Hexachlorobenzene results in increased expression of IL2RA mRNA CTD PMID:9465272 NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071
JBrowse link
G Il2rb interleukin 2 receptor subunit beta affects expression EXP Hexachlorobenzene affects the expression of IL2RB mRNA CTD PMID:15159207 NCBI chr 7:119,701,338...119,716,238
Ensembl chr 7:119,701,251...119,716,238
JBrowse link
G Il4 interleukin 4 affects expression EXP Hexachlorobenzene affects the expression of IL4 protein CTD PMID:11119253 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il5 interleukin 5 decreases expression ISO Hexachlorobenzene results in decreased expression of IL5 protein CTD PMID:15319175 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Il6 interleukin 6 increases expression EXP Hexachlorobenzene results in increased expression of IL6 mRNA CTD PMID:15159207 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Il6st interleukin 6 signal transducer increases expression EXP Hexachlorobenzene results in increased expression of IL6ST mRNA CTD PMID:15159207 NCBI chr 2:44,279,199...44,319,427
Ensembl chr 2:44,289,393...44,314,944
JBrowse link
G Insr insulin receptor increases expression EXP
ISO
Hexachlorobenzene results in increased expression of INSR protein CTD PMID:16237195, PMID:19879930 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
JBrowse link
G Irf1 interferon regulatory factor 1 decreases expression EXP Hexachlorobenzene results in decreased expression of IRF1 mRNA CTD PMID:15159207 NCBI chr10:39,109,530...39,116,532
Ensembl chr10:39,109,522...39,116,531
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions
increases phosphorylation
increases expression
EXP
ISO
Hexachlorobenzene inhibits the reaction [Methylnitrosourea results in increased phosphorylation of IRS1 protein]
Hexachlorobenzene results in increased phosphorylation of IRS1 protein
[Hexachlorobenzene co-treated with Estradiol] results in increased phosphorylation of IRS1 protein; fulvestrant inhibits the reaction [[Hexachlorobenzene co-treated with Estradiol] results in increased phosphorylation of IRS1 protein]; fulvestrant inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of IRS1 protein]
Hexachlorobenzene results in increased expression of IRS1 protein
CTD PMID:16237195, PMID:19879930 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression EXP Hexachlorobenzene results in increased expression of JUN protein CTD PMID:9630449 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kdr kinase insert domain receptor increases expression ISO Hexachlorobenzene results in increased expression of KDR protein CTD PMID:26358519 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Lcn2 lipocalin 2 increases expression EXP Hexachlorobenzene results in increased expression of LCN2 mRNA CTD PMID:15159207 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546
JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression EXP Hexachlorobenzene results in decreased expression of LHB protein CTD PMID:22245120 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Lman1 lectin, mannose-binding, 1 increases expression EXP Hexachlorobenzene results in increased expression of LMAN1 mRNA CTD PMID:15159207 NCBI chr18:61,683,377...61,707,344
Ensembl chr18:61,685,117...61,707,317
JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 affects expression EXP Hexachlorobenzene affects the expression of MAP3K1 mRNA CTD PMID:15159207 NCBI chr 2:43,329,516...43,393,203
Ensembl chr 2:43,329,516...43,393,207
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
affects localization
ISO
EXP
[alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK1 protein]; [Phenanthrolines binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK1 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK1 protein]; alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of MAPK1 protein]; Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK1 protein; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of MAPK1 protein]; Protein Kinase Inhibitors inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of MAPK1 protein]
[Hexachlorobenzene results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK1 protein
Hexachlorobenzene affects the localization of MAPK1 protein
CTD PMID:21205633, PMID:21787832, PMID:22245120, PMID:23708402, PMID:26219504, PMID:26358519, PMID:28923513 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 affects expression EXP Hexachlorobenzene affects the expression of MAPK14 mRNA CTD PMID:15159207 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
affects localization
ISO
EXP
[alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [Phenanthrolines binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK3 protein]; alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of MAPK3 protein]; Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK3 protein; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of MAPK3 protein]; Protein Kinase Inhibitors inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of MAPK3 protein]
[Hexachlorobenzene results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK3 protein
Hexachlorobenzene affects the localization of MAPK3 protein
CTD PMID:21205633, PMID:22245120, PMID:23708402, PMID:26219504, PMID:26358519, PMID:28923513 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation EXP Hexachlorobenzene results in increased phosphorylation of MAPK8 protein CTD PMID:23708402 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mcpt10 mast cell protease 10 increases expression EXP Hexachlorobenzene results in increased expression of MCPT10 mRNA CTD PMID:15159207 NCBI chr15:34,644,471...34,647,497
Ensembl chr15:34,644,464...34,694,244
JBrowse link
G Med16 mediator complex subunit 16 decreases expression EXP Hexachlorobenzene results in decreased expression of MED16 mRNA CTD PMID:23153324 NCBI chr 7:12,619,739...12,632,241
Ensembl chr 7:12,542,713...12,632,298
JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression
multiple interactions
ISO Hexachlorobenzene results in increased expression of MMP2 mRNA; Hexachlorobenzene results in increased expression of MMP2 protein
AG 1879 inhibits the reaction [Hexachlorobenzene results in increased expression of MMP2 protein]; RTKI cpd inhibits the reaction [Hexachlorobenzene results in increased expression of MMP2 protein]
CTD PMID:23462309 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression
multiple interactions
EXP
ISO
Hexachlorobenzene results in increased expression of MMP9 mRNA
alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased secretion of and results in increased activity of MMP9 protein]; Hexachlorobenzene results in increased secretion of and results in increased activity of MMP9 protein; RTKI cpd inhibits the reaction [Hexachlorobenzene results in increased secretion of and results in increased activity of MMP9 protein]
CTD PMID:15159207, PMID:23462309 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpst mercaptopyruvate sulfurtransferase increases expression EXP Hexachlorobenzene results in increased expression of MPST mRNA CTD PMID:15159207 NCBI chr 7:119,626,636...119,631,317
Ensembl chr 7:119,626,637...119,631,425
JBrowse link
G Mt1 metallothionein 1 increases expression EXP Hexachlorobenzene results in increased expression of MT1A mRNA CTD PMID:15159207 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases expression EXP Hexachlorobenzene results in decreased expression of MTOR mRNA CTD PMID:15159207 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO [Hexachlorobenzene co-treated with Diethylnitrosamine] results in increased expression of NFE2L2 protein CTD PMID:28634113 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nos1 nitric oxide synthase 1 affects expression ISO Hexachlorobenzene affects the expression of NOS1 protein CTD PMID:32526215 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nos2 nitric oxide synthase 2 affects expression ISO Hexachlorobenzene affects the expression of NOS2 protein CTD PMID:32526215 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 decreases expression
affects expression
EXP
ISO
Hexachlorobenzene results in decreased expression of NOS3 protein
Hexachlorobenzene affects the expression of NOS3 protein
CTD PMID:29277037, PMID:32526215 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP Hexachlorobenzene results in increased expression of NQO1 mRNA CTD PMID:23153324 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 decreases expression EXP Hexachlorobenzene results in decreased expression of NR1D1 mRNA CTD PMID:23153324 NCBI chr10:86,683,875...86,690,815
Ensembl chr10:86,683,875...86,690,815
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO Hexachlorobenzene results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Orm1 orosomucoid 1 increases expression EXP Hexachlorobenzene results in increased expression of ORM1 mRNA CTD PMID:15159207 NCBI chr 5:79,179,668...79,182,820
Ensembl chr 5:79,179,417...79,182,820
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
decreases expression
increases expression
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hexachlorobenzene results in increased expression of PCNA protein]
Hexachlorobenzene results in decreased expression of PCNA protein
CTD PMID:26219504, PMID:29277037 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pglyrp1 peptidoglycan recognition protein 1 increases expression EXP Hexachlorobenzene results in increased expression of PGLYRP1 mRNA CTD PMID:15159207 NCBI chr 1:79,790,879...79,796,064
Ensembl chr 1:79,790,705...79,796,111
JBrowse link
G Plpp2 phospholipid phosphatase 2 increases expression EXP Hexachlorobenzene results in increased expression of PLPP2 mRNA CTD PMID:15159207 NCBI chr 7:13,062,168...13,070,281
Ensembl chr 7:13,062,196...13,070,280
JBrowse link
G Por cytochrome p450 oxidoreductase decreases expression EXP Hexachlorobenzene results in decreased expression of POR mRNA CTD PMID:15159207 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Ppox protoporphyrinogen oxidase affects expression EXP Hexachlorobenzene affects the expression of PPOX mRNA CTD PMID:15159207 NCBI chr13:89,650,094...89,654,998
Ensembl chr13:89,650,094...89,654,244
JBrowse link
G Prdx2 peroxiredoxin 2 increases expression EXP Hexachlorobenzene results in increased expression of PRDX2 mRNA CTD PMID:15159207 NCBI chr19:26,084,816...26,090,095
Ensembl chr19:26,084,903...26,090,094
JBrowse link
G Prl prolactin increases expression EXP Hexachlorobenzene results in increased expression of PRL protein CTD PMID:22245120 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO Hexachlorobenzene results in increased expression of PTGS2 protein
alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased expression of PTGS2 protein]; Fulvestrant inhibits the reaction [Hexachlorobenzene results in increased expression of PTGS2 protein]; omega-N-Methylarginine inhibits the reaction [Hexachlorobenzene results in increased expression of PTGS2 protein]
CTD PMID:26358519, PMID:32526215 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G RatNP-3b defensin RatNP-3 precursor increases expression EXP Hexachlorobenzene results in increased expression of RATNP-3B mRNA CTD PMID:15159207 NCBI chr16:75,528,348...75,530,511
Ensembl chr16:75,497,832...75,530,517
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [Hexachlorobenzene co-treated with Diethylnitrosamine] results in increased expression of RELA protein; Cholecalciferol inhibits the reaction [[Hexachlorobenzene co-treated with Diethylnitrosamine] results in increased expression of RELA protein] CTD PMID:28634113 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rgcc regulator of cell cycle affects expression EXP Hexachlorobenzene affects the expression of RGCC mRNA CTD PMID:15159207 NCBI chr15:61,551,861...61,564,695
Ensembl chr15:61,551,861...61,564,695
JBrowse link
G RT1-Bb RT1 class II, locus Bb affects expression
increases expression
EXP Hexachlorobenzene affects the expression of RT1-BB mRNA
Hexachlorobenzene results in increased expression of RT1-BB mRNA
CTD PMID:15159207, PMID:17202759 NCBI chr20:4,043,726...4,049,367
Ensembl chr20:4,039,413...4,049,711
JBrowse link
G RT1-Da RT1 class II, locus Da decreases expression EXP Hexachlorobenzene results in decreased expression of RT1-DA mRNA CTD PMID:15159207 NCBI chr20:4,127,644...4,132,616
Ensembl chr20:4,127,644...4,132,616
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 affects expression EXP Hexachlorobenzene affects the expression of RT1-DB1 mRNA CTD PMID:15159207 NCBI chr20:4,087,621...4,097,190
Ensembl chr20:4,087,618...4,097,190
JBrowse link
G RT1-DMa RT1 class II, locus DMa decreases expression EXP Hexachlorobenzene results in decreased expression of HLA-DMA mRNA CTD PMID:15159207 NCBI chr20:3,935,512...3,938,915
Ensembl chr20:5,240,975...5,244,386
JBrowse link
G RT1-DMb RT1 class II, locus DMb decreases expression EXP Hexachlorobenzene results in decreased expression of HLA-DMB mRNA CTD PMID:15159207 NCBI chr20:3,945,383...3,952,838
Ensembl chr20:5,227,045...5,234,290
JBrowse link
G RT1-S3 RT1 class Ib, locus S3 increases expression EXP Hexachlorobenzene results in increased expression of RT1-S3 mRNA CTD PMID:15159207 NCBI chr20:3,176,124...3,180,825
Ensembl chr20:3,176,107...3,179,818
JBrowse link
G Rxrb retinoid X receptor beta increases activity ISO Hexachlorobenzene results in increased activity of RXRB protein CTD PMID:18207673 NCBI chr20:3,822,673...3,829,138
Ensembl chr20:3,823,042...3,829,140
JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression EXP Hexachlorobenzene results in increased expression of S100A8 mRNA CTD PMID:15159207 NCBI chr 2:190,073,239...190,074,333
Ensembl chr 2:190,073,815...190,074,354
JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression EXP Hexachlorobenzene results in increased expression of S100A9 mRNA CTD PMID:15159207 NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276
JBrowse link
G Scnn1a sodium channel epithelial 1 subunit alpha increases expression EXP Hexachlorobenzene results in increased expression of SCNN1A mRNA CTD PMID:23153324 NCBI chr 4:157,834,339...157,860,472
Ensembl chr 4:157,836,912...157,860,049
JBrowse link
G Serpina7 serpin family A member 7 decreases expression ISO Hexachlorobenzene results in decreased expression of SERPINA7 protein CTD PMID:19750101 NCBI chr  X:110,226,565...110,232,202
Ensembl chr  X:110,226,572...110,232,179
JBrowse link
G Sh2b3 SH2B adaptor protein 3 decreases expression EXP Hexachlorobenzene results in decreased expression of LNK mRNA CTD PMID:15159207 NCBI chr12:40,261,990...40,265,757
Ensembl chr12:40,244,081...40,265,757
JBrowse link
G Slc2a4 solute carrier family 2 member 4 decreases expression EXP Hexachlorobenzene results in decreased expression of SLC2A4 protein CTD PMID:31923579 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Smad3 SMAD family member 3 multiple interactions
increases phosphorylation
ISO AG 1879 inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of SMAD3 protein]; alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of SMAD3 protein]; Hexachlorobenzene results in increased phosphorylation of and affects the localization of SMAD3 protein CTD PMID:27519288, PMID:28923513 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Socs2 suppressor of cytokine signaling 2 affects expression EXP Hexachlorobenzene affects the expression of SOCS2 mRNA CTD PMID:15159207 NCBI chr 7:36,495,496...36,500,878
Ensembl chr 7:36,495,480...36,499,784
JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression EXP Hexachlorobenzene results in increased expression of SOCS3 mRNA CTD PMID:15159207 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
JBrowse link
G Sod1 superoxide dismutase 1 increases expression EXP Hexachlorobenzene results in increased expression of SOD1 mRNA CTD PMID:15159207 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 affects expression EXP Hexachlorobenzene affects the expression of SOD2 mRNA CTD PMID:15159207 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sod3 superoxide dismutase 3 affects expression EXP Hexachlorobenzene affects the expression of SOD3 mRNA CTD PMID:15159207 NCBI chr14:60,958,583...60,971,143
Ensembl chr14:60,958,592...60,964,324
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions
affects localization
increases phosphorylation
ISO
EXP
[AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of EGFR protein]; [AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of STAT5B protein]; [AG 1879 results in decreased activity of SRC protein] which results in decreased susceptibility to Hexachlorobenzene; Hexachlorobenzene affects the phosphorylation of and affects the activity of SRC protein; Hexachlorobenzene affects the reaction [CDKN1B protein binds to SRC protein]
Hexachlorobenzene affects the localization of SRC protein
Hexachlorobenzene results in increased phosphorylation of SRC protein
AG 1879 inhibits the reaction [SRC protein promotes the reaction [Hexachlorobenzene results in increased phosphorylation of EGFR protein]]; Hexachlorobenzene promotes the reaction [EGFR protein binds to SRC protein]; Hexachlorobenzene promotes the reaction [ESR1 protein binds to SRC protein]; Hexachlorobenzene promotes the reaction [Methylnitrosourea promotes the reaction [EGFR protein binds to SRC protein]]; Hexachlorobenzene promotes the reaction [Methylnitrosourea results in increased phosphorylation of SRC protein]; Hexachlorobenzene results in increased expression of and results in increased phosphorylation of and results in increased activity of SRC protein; Hexachlorobenzene results in increased phosphorylation of and results in increased expression of SRC protein; Methylnitrosourea inhibits the reaction [Hexachlorobenzene promotes the reaction [ESR1 protein binds to SRC protein]]; Methylnitrosourea promotes the reaction [Hexachlorobenzene promotes the reaction [EGFR protein binds to SRC protein]]; Methylnitrosourea promotes the reaction [Hexachlorobenzene results in increased phosphorylation of SRC protein]; SRC protein promotes the reaction [Hexachlorobenzene results in increased phosphorylation of EGFR protein]
CTD PMID:18295415, PMID:19879930, PMID:21205633, PMID:22245120, PMID:23462309, PMID:28215542 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Stat1 signal transducer and activator of transcription 1 increases expression EXP Hexachlorobenzene results in increased expression of STAT1 mRNA CTD PMID:15159207 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stat5b signal transducer and activator of transcription 5B multiple interactions ISO
EXP
[AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of STAT5B protein]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein]; [Phenanthrolines binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein]; Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein
Hexachlorobenzene affects the expression of and affects the phosphorylation of STAT5B protein
CTD PMID:21205633, PMID:22245120 NCBI chr10:88,686,207...88,712,313
Ensembl chr10:88,686,207...88,754,829
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases expression EXP Hexachlorobenzene results in increased expression of SULT1A1 mRNA CTD PMID:15159207 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 increases expression EXP Hexachlorobenzene results in increased expression of SULT1E1 mRNA CTD PMID:15159207 NCBI chr14:22,070,861...22,089,264
Ensembl chr14:22,072,024...22,089,248
JBrowse link
G Tf transferrin increases expression EXP Hexachlorobenzene results in increased expression of TF mRNA CTD PMID:15159207 NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
JBrowse link
G Tfrc transferrin receptor affects expression EXP Hexachlorobenzene affects the expression of TFRC mRNA CTD PMID:15159207 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Tgfa transforming growth factor alpha multiple interactions ISO [Hexachlorobenzene co-treated with Diethylnitrosamine co-treated with Cholecalciferol] results in increased expression of TGFA protein; [Hexachlorobenzene co-treated with Diethylnitrosamine] results in increased expression of TGFA protein CTD PMID:28634113 NCBI chr 4:117,961,877...118,045,923
Ensembl chr 4:117,962,319...118,046,344
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
multiple interactions
affects expression
EXP
ISO
Hexachlorobenzene results in increased expression of TGFB1 mRNA; Hexachlorobenzene results in increased expression of TGFB1 protein
Hexachlorobenzene affects the reaction [AHR protein affects the expression of TGFB1 mRNA]
Hexachlorobenzene affects the expression of TGFB1 mRNA
alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased expression of TGFB1 mRNA]; Hexachlorobenzene results in increased expression of and results in increased cleavage of TGFB1 protein
CTD PMID:19182106, PMID:21787832, PMID:25093615, PMID:27519288, PMID:28923513, PMID:29277037 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfb3 transforming growth factor, beta 3 decreases expression EXP Hexachlorobenzene results in decreased expression of TGFB3 mRNA CTD PMID:15159207 NCBI chr 6:109,913,757...109,936,217
Ensembl chr 6:109,913,757...109,935,533
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 increases expression ISO Hexachlorobenzene results in increased expression of TGFBR1 mRNA CTD PMID:28923513 NCBI chr 5:63,056,071...63,119,635
Ensembl chr 5:63,050,758...63,119,635
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 multiple interactions
affects expression
ISO Hexachlorobenzene affects the reaction [AHR protein affects the expression of TGFBR2 mRNA]
Hexachlorobenzene affects the expression of TGFBR2 mRNA
CTD PMID:28923513 NCBI chr 8:124,310,288...124,399,345
Ensembl chr 8:124,312,754...124,399,494
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP Hexachlorobenzene results in increased expression of TIMP1 mRNA CTD PMID:15159207 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression EXP Hexachlorobenzene results in increased expression of TIMP2 mRNA CTD PMID:15159207 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression EXP Hexachlorobenzene results in increased expression of TNFRSF1A mRNA CTD PMID:15159207 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
G Tsc22d1 TSC22 domain family, member 1 decreases expression EXP Hexachlorobenzene results in decreased expression of TSC22D1 mRNA CTD PMID:15159207 NCBI chr15:58,554,358...58,658,156
Ensembl chr15:58,554,374...58,658,153
JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions ISO Hexachlorobenzene affects the expression of and affects the secretion of TSHB protein CTD PMID:19750101 NCBI chr 2:205,207,799...205,215,199
Ensembl chr 2:205,207,799...205,212,681
JBrowse link
G Ttr transthyretin affects binding EXP Hexachlorobenzene binds to TTR protein CTD PMID:2043046 NCBI chr18:15,532,963...15,542,180
Ensembl chr18:15,532,963...15,540,177
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression
decreases expression
EXP Hexachlorobenzene results in increased expression of TXNRD1 mRNA
Hexachlorobenzene results in decreased expression of TXNRD1 mRNA
CTD PMID:23153324 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 increases expression EXP Hexachlorobenzene results in increased expression of UGT2B1 mRNA CTD PMID:15159207 NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444
JBrowse link
G Ugt8 UDP glycosyltransferase 8 increases expression EXP Hexachlorobenzene results in increased expression of UGT8 mRNA CTD PMID:15159207 NCBI chr 2:229,644,373...229,718,678
Ensembl chr 2:229,644,382...229,718,659
JBrowse link
G Urod uroporphyrinogen decarboxylase affects expression
multiple interactions
EXP
ISO
Hexachlorobenzene affects the expression of UROD mRNA
Hexachlorobenzene promotes the reaction [Aminolevulinic Acid results in decreased activity of UROD protein]
CTD PMID:8937451, PMID:15159207 NCBI chr 5:135,855,429...135,859,515
Ensembl chr 5:135,855,433...135,859,643
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression EXP Hexachlorobenzene results in increased expression of VCAM1 mRNA CTD PMID:15159207 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vdr vitamin D receptor multiple interactions ISO [Hexachlorobenzene co-treated with Diethylnitrosamine] results in decreased expression of VDR protein; Cholecalciferol inhibits the reaction [[Hexachlorobenzene co-treated with Diethylnitrosamine] results in increased expression of VDR protein] CTD PMID:28634113 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
JBrowse link
G Vegfa vascular endothelial growth factor A increases secretion
increases expression
multiple interactions
ISO Hexachlorobenzene results in increased secretion of VEGFA protein
Hexachlorobenzene results in increased expression of VEGFA protein
alpha-naphthoflavone affects the reaction [Hexachlorobenzene results in increased expression of VEGFA protein]; alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased secretion of VEGFA protein]; Fulvestrant inhibits the reaction [Hexachlorobenzene results in increased expression of VEGFA protein]; Hexachlorobenzene results in increased expression of and results in increased secretion of VEGFA protein; omega-N-Methylarginine inhibits the reaction [Hexachlorobenzene results in increased expression of VEGFA protein]
CTD PMID:26358519, PMID:32526215 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        aetiopathogenetic role 18960
          carcinogenic agent 18331
            hexachlorobenzene 201
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                carbocyclic compound 18222
                                  benzenoid aromatic compound 17254
                                    benzenes 17010
                                      chlorobenzenes 13342
                                        hexachlorobenzene 201
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.