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ONTOLOGY REPORT - ANNOTATIONS


Term:hydroxychloroquine
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Accession:CHEBI:5801 term browser browse the term
Definition:An aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions.
Synonyms:exact_synonym: 2-[{4-[(7-chloroquinolin-4-yl)amino]pentyl}(ethyl)amino]ethanol
 related_synonym: 2-((4-((7-chloro-4-quinolyl)amino)pentyl)ethylamino)ethanol;   2-(N-(4-(7-chlor-4-chinolylamino)-4-methylbutyl)ethylamino)ethanol;   7-chloro-4-(4-(ethyl(2-hydroxyethyl)amino)-1-methylbutylamino)quinoline;   7-chloro-4-[4-(N-ethyl-N-beta-hydroxyethylamino)-1-methylbutylamino]quinoline;   7-chloro-4-[5-(N-ethyl-N-2-hydroxyethylamino)-2-pentyl]aminoquinoline;   Formula=C18H26ClN3O;   InChI=1S/C18H26ClN3O/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);   InChIKey=XXSMGPRMXLTPCZ-UHFFFAOYSA-N;   NSC4375;   Polirreumin;   SMILES=CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12;   hidroxicloroquina;   hydroxychloroquinum;   oxichlorochine;   oxichloroquine
 xref: CAS:118-42-3 "ChemIDplus";   CAS:118-42-3 "KEGG COMPOUND";   CAS:118-42-3 "NIST Chemistry WebBook";   DrugBank:DB01611;   Drug_Central:1395 "DrugCentral";   HMDB:HMDB0015549;   KEGG:C07043;   KEGG:D08050;   LINCS:LSM-5193
 xref_mesh: MESH:D006886
 xref: PMID:23216212 "Europe PMC";   PMID:23218706 "Europe PMC";   PMID:23481418 "Europe PMC";   PMID:23485647 "Europe PMC";   PMID:23581274 "Europe PMC";   PMID:23778483 "Europe PMC";   PMID:23887202 "Europe PMC";   PMID:23902281 "Europe PMC";   Patent:US2546658;   Reaxys:253894 "Reaxys";   Wikipedia:Hydroxychloroquine


show annotations for term's descendants       view all columns           Sort by:
 
hydroxychloroquine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Cflar CASP8 and FADD-like apoptosis regulator JBrowse link 9 65,534,608 65,586,395 RGD:6480464
G Cldn1 claudin 1 JBrowse link 11 77,815,216 77,830,373 RGD:6480464
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:6480464
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Ocln occludin JBrowse link 2 30,527,327 30,577,218 RGD:6480464
G Sqstm1 sequestosome 1 JBrowse link 10 35,704,728 35,716,316 RGD:6480464
G Txnip thioredoxin interacting protein JBrowse link 2 198,683,168 198,686,971 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19716
    role 19663
      application 19308
        pharmaceutical 19179
          drug 19179
            antirheumatic drug 14627
              hydroxychloroquine 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 19716
    subatomic particle 19712
      composite particle 19712
        hadron 19712
          baryon 19712
            nucleon 19712
              atomic nucleus 19712
                atom 19712
                  main group element atom 19598
                    main group molecular entity 19598
                      s-block molecular entity 19361
                        hydrogen molecular entity 19350
                          hydrides 18280
                            inorganic hydride 17204
                              pnictogen hydride 17166
                                nitrogen hydride 17003
                                  azane 16693
                                    ammonia 16690
                                      organic amino compound 16689
                                        aromatic amine 13593
                                          aminoquinoline 1564
                                            chloroquine 125
                                              hydroxychloroquine 12
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