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ONTOLOGY REPORT - ANNOTATIONS


Term:methysergide
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Accession:CHEBI:584020 term browser browse the term
Definition:A synthetic ergot alkaloid, structurally related to the oxytocic agent methylergonovine and to the potent hallucinogen LSD and used prophylactically to reduce the frequency and intensity of severe vascular headaches.
Synonyms:exact_synonym: (8R)-N-[1-hydroxymethyl(propyl)]-1,6-dimethyl-9,10-didehydroergoline-8-carboxamide
 related_synonym: (+)-9,10-Didehydro-N-(1-(hydroxymethyl)propyl)-1,6-dimethylergoline-8beta-carboxamide;   (+)-N-(1-(Hydroxymethyl)propyl)-1-methyl-D-lysergamide;   1-Methyl-D-lysergic acid butanolamide;   1-Methyl-dextro-lysergic acid (+)-1-hydroxy-2-butylamide;   1-Methyllysergic acid butanolamide;   1-Methylmethylergonovine;   9,10-Didehydro-N-(1-(hydroxymethyl)propyl)-1,6-dimethylergoline-8-carboxamide;   Formula=C21H27N3O2;   InChI=1S/C21H27N3O2/c1-4-15(12-25)22-21(26)14-8-17-16-6-5-7-18-20(16)13(10-23(18)2)9-19(17)24(3)11-14/h5-8,10,14-15,19,25H,4,9,11-12H2,1-3H3,(H,22,26)/t14-,15?,19-/m1/s1;   InChIKey=KPJZHOPZRAFDTN-NQUBZZJWSA-N;   N-(1-(Hydroxymethyl)propyl)-1-methyl-dextro-(+)-lysergamide;   SMILES=[H][C@@]12Cc3cn(C)c4cccc(C1=C[C@H](CN2C)C(=O)NC(CC)CO)c34;   methysergidum;   metisergida
 alt_id: CHEBI:6893
 xref: Beilstein:765986 "Beilstein";   CAS:361-37-5 "ChemIDplus";   DrugBank:DB00247;   KEGG:C07199;   KEGG:D02357
 xref_mesh: MESH:D008784
 xref: Patent:GB854569;   Patent:US3113133


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methysergide term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb4 ATP binding cassette subfamily B member 4 JBrowse link 4 22,133,984 22,192,687 RGD:6480464
G Adra1a adrenoceptor alpha 1A JBrowse link 15 43,296,997 43,398,314 RGD:6480464
G Calca calcitonin-related polypeptide alpha JBrowse link 1 184,184,018 184,188,922 RGD:6480464
G Htr1b 5-hydroxytryptamine receptor 1B JBrowse link 8 89,113,984 89,130,830 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19728
    role 19675
      biological role 19673
        pharmacological role 18793
          neurotransmitter agent 16396
            serotonergic drug 3917
              serotonergic antagonist 2224
                methysergide 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    p-block element atom 19610
                      carbon group element atom 19501
                        carbon atom 19494
                          organic molecular entity 19494
                            organic group 18413
                              organic divalent group 18404
                                organodiyl group 18404
                                  carbonyl group 18293
                                    carbonyl compound 18293
                                      carboxylic acid 17960
                                        carboacyl group 17072
                                          univalent carboacyl group 17072
                                            carbamoyl group 16801
                                              carboxamide 16801
                                                monocarboxylic acid amide 14163
                                                  methysergide 4
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.