Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ibuprofen
go back to main search page
Accession:CHEBI:5855 term browser browse the term
Definition:A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(2-methylpropyl)phenyl group.
Synonyms:exact_synonym: 2-[4-(2-methylpropyl)phenyl]propanoic acid
 related_synonym: (+-)-2-(p-isobutylphenyl)propionic acid;   (+-)-alpha-methyl-4-(2-methylpropyl)benzeneacetic acid;   (+-)-p-isobutylhydratropic acid;   (4-isobutylphenyl)-alpha-methylacetic acid;   (RS)-ibuprofen;   2-(4-isobutylphenyl)propanoic acid;   4-isobutylhydratropic acid;   Adran;   Advil;   Amibufen;   Anco;   Anflagen;   Apsifen;   Bluton;   Brufen;   Brufort;   Buburone;   Butylenin;   Dolgin;   Dolgirid;   Dolgit;   Dolo-Dolgit;   Ebufac;   Epobron;   Femadon;   Formula=C13H18O2;   Haltran;   Ibu-Attritin;   Ibumetin;   Ibuprocin;   Ibutid;   InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15);   InChIKey=HEFNNWSXXWATRW-UHFFFAOYSA-N;   Inabrin;   Inoven;   Lamidon;   Lebrufen;   Liptan;   Medipren;   Motrin;   Mynosedin;   Nobfen;   Nobgen;   Nuprin;   Nurofen;   Pediaprofen;   Roidenin;   Rufen;   SMILES=CC(C)Cc1ccc(cc1)C(C)C(O)=O;   Seclodin;   Suspren;   Tabalon;   Trendar;   Urem;   alpha-(4-isobutylphenyl)propionic acid;   alpha-(p-isobutylphenyl)propionic acid
 xref: Beilstein:2049713;   CAS:15687-27-1;   DrugBank:DB01050;   Drug_Central:1407;   HMDB:HMDB0001925;   KEGG:C01588;   KEGG:D00126;   LINCS:LSM-1354
 xref_mesh: MESH:D007052
 xref: PMID:11433218;   PMID:12723739;   PMID:14562167;   PMID:15506544;   PMID:16176022;   PMID:18335846;   PMID:18697608;   PMID:21368281;   PMID:24168233;   PMID:25708941;   PMID:25915907;   PMID:29756342;   Patent:GB971700;   Patent:US3228831;   Patent:US3385886;   Patent:US5215755;   Patent:US6727286;   Reaxys:2049713;   Wikipedia:Ibuprofen
 cyclic_relationship: is_conjugate_acid_of CHEBI:132922


show annotations for term's descendants           Sort by:
 
ibuprofen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOS3 nitric oxide synthase 3 decreases expression
multiple interactions
EXP Ibuprofen results in decreased expression of NOS3 mRNA
11-deoxy-16-phenoxy-17,18,19,20-tetranorprostaglandin E1 inhibits the reaction [Ibuprofen results in decreased expression of NOS3 mRNA]; 11-deoxyprostaglandin E1 inhibits the reaction [Ibuprofen results in decreased expression of NOS3 mRNA]; 16,16-Dimethylprostaglandin E2 inhibits the reaction [Ibuprofen results in decreased expression of NOS3 mRNA]; sulprostone inhibits the reaction [Ibuprofen results in decreased expression of NOS3 mRNA]
CTD PMID:10525081, PMID:10644584 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,156...6,228,938
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 876
    role 856
      biological role 856
        xenobiotic 113
          ibuprofen 1
            carboxyibuprofen 0
            dexibuprofen 0
            ibuproxam 0
            levibuprofen 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 876
    subatomic particle 861
      composite particle 861
        hadron 861
          baryon 861
            nucleon 861
              atomic nucleus 861
                atom 861
                  main group element atom 851
                    p-block element atom 848
                      carbon group element atom 823
                        carbon atom 822
                          organic molecular entity 822
                            organic group 390
                              organic divalent group 388
                                organodiyl group 388
                                  carbonyl group 387
                                    carbonyl compound 387
                                      carboxylic acid 266
                                        monocarboxylic acid 135
                                          fatty acid 77
                                            saturated fatty acid 71
                                              propionic acid 10
                                                ibuprofen 1
                                                  carboxyibuprofen 0
                                                  dexibuprofen 0
                                                  ibuproxam 0
                                                  levibuprofen 0
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.