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Accession:CHEBI:59560 term browser browse the term
Definition:A tetrahydropterin that is 2-amino-5,6,7,8-tetrahydropteridin-4(3H)-one in which a hydrogen at position 6 is substituted by a 1,2-dihydroxypropyl group (6R,1'R,2'S-enantiomer).
Synonyms:exact_synonym: (6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(3H)-one
 related_synonym: (-)-(6R)-2-amino-6-((1R,2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4(3H)-pteridinone;   (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin;   (6R)-L-erythro-tetrahydrobiopterin;   2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydoro-4(1H)-pteridinone;   5,6,7,8-Tetrahydrobiopterin;   6R-5,6,7,8-tetrahydrobiopterin;   6R-BH4;   6R-L-5,6,7,8-tetrahydrobiopterin;   Formula=C9H15N5O3;   InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17)/t3-,4+,6-/m0/s1;   InChIKey=FNKQXYHWGSIFBK-RPDRRWSUSA-N;   R-THBP;   SMILES=[H][C@@]1(CNc2nc(N)[nH]c(=O)c2N1)[C@@H](O)[C@H](C)O;   sapropterina;   sapropterinum;   tetrahydrobiopterin
 alt_id: CHEBI:64242
 xref: Beilstein:4699705 "Beilstein";   CAS:17528-72-2 "KEGG COMPOUND";   CAS:27070-47-9 "ChemIDplus";   DrugBank:DB00360;   Drug_Central:2612 "DrugCentral";   HMDB:HMDB0000787;   KEGG:C00272;   KEGG:D08505;   KNApSAcK:C00018229
 xref_mesh: MESH:C003402
 xref: MetaCyc:CPD-14053;   PDBeChem:H4B;   PMID:10333495 "SUBMITTER";   PMID:1297822 "Europe PMC";   PMID:16510994 "SUBMITTER";   PMID:19627172 "Europe PMC";   PMID:21466737 "Europe PMC";   PMID:21646032 "Europe PMC";   PMID:22110560 "Europe PMC";   PMID:22112818 "Europe PMC";   PMID:22310224 "Europe PMC";   PMID:22388642 "Europe PMC";   PMID:22391997 "Europe PMC";   PMID:22575621 "Europe PMC";   PMID:22832064 "Europe PMC";   PMID:23235653 "Europe PMC";   PMID:23266371 "Europe PMC";   PMID:23430527 "Europe PMC";   PMID:23430545 "Europe PMC";   PMID:23436109 "Europe PMC";   PMID:23462988 "Europe PMC";   PMID:23690520 "Europe PMC";   PMID:23705856 "Europe PMC";   PMID:23712020 "Europe PMC";   PMID:23743404 "Europe PMC";   PMID:4004257 "Europe PMC";   Patent:EP191335;   Patent:US4713454;   Reaxys:4699705 "Reaxys";   Wikipedia:Sapropterin

show annotations for term's descendants       view all columns           Sort by:
sapropterin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adipoq adiponectin, C1Q and collagen domain containing JBrowse link 11 81,330,845 81,344,488 RGD:6480464
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Epo erythropoietin JBrowse link 12 22,274,828 22,278,268 RGD:6480464
G Gch1 GTP cyclohydrolase 1 JBrowse link 15 23,935,011 23,968,971 RGD:6480464
G Nos3 nitric oxide synthase 3 JBrowse link 4 7,321,908 7,342,404 RGD:6480464
G Sct secretin JBrowse link 1 214,264,865 214,277,437 RGD:6480464
G Snca synuclein alpha JBrowse link 4 90,782,412 90,883,236 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19657
    role 19601
      biological role 19599
        biochemical role 19130
          cofactor 15855
            sapropterin 9
              sapropterin dihydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19657
    subatomic particle 19653
      composite particle 19653
        hadron 19653
          baryon 19653
            nucleon 19653
              atomic nucleus 19653
                atom 19653
                  main group element atom 19534
                    p-block element atom 19534
                      carbon group element atom 19417
                        carbon atom 19409
                          organic molecular entity 19409
                            organic molecule 19332
                              organic cyclic compound 19083
                                organic heterocyclic compound 18154
                                  organic heteropolycyclic compound 17419
                                    organic heterobicyclic compound 15891
                                      pteridines 5246
                                        pterins 3701
                                          biopterins 11
                                            5,6,7,8-tetrahydrobiopterin 9
                                              sapropterin 9
                                                sapropterin dihydrochloride 0
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.