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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:diflorasone
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Accession:CHEBI:59750 term browser browse the term
Definition:The 16beta-analogue of flumethasone. It is used as the 17,21-diacetate as a topical anti-inflammatory and antipruritic in the treatment of various skin disorders.
Synonyms:exact_synonym: 6alpha,9-difluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione
 related_synonym: (6alpha,11beta,16beta)-6,9-difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione;   Formula=C22H28F2O5;   InChI=1S/C22H28F2O5/c1-11-6-13-14-8-16(23)15-7-12(26)4-5-19(15,2)21(14,24)17(27)9-20(13,3)22(11,29)18(28)10-25/h4-5,7,11,13-14,16-17,25,27,29H,6,8-10H2,1-3H3/t11-,13-,14-,16-,17-,19-,20-,21-,22-/m0/s1;   InChIKey=WXURHACBFYSXBI-XHIJKXOTSA-N;   SMILES=[H][C@@]12C[C@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])C[C@H](F)C2=CC(=O)C=C[C@]12C;   diflorasona;   diflorasonum
 xref: Beilstein:5645455;   CAS:2557-49-5;   DrugBank:DB00223;   KEGG:D07827
 xref_mesh: MESH:C014477
 xref: Patent:GB881334;   Patent:GB898293;   Patent:GB912015;   Patent:US3557158;   Wikipedia:Diflorasone


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diflorasone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl17 C-C motif chemokine ligand 17 multiple interactions ISO diflorasone inhibits the reaction [Dinitrochlorobenzene results in increased expression of CCL17 protein]; diflorasone promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL17 protein] CTD PMID:15491423 NCBI chr19:10,619,220...10,620,671
Ensembl chr19:10,619,220...10,620,671
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO diflorasone inhibits the reaction [Dinitrochlorobenzene results in increased expression of CCL5 protein]; diflorasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL5 protein] CTD PMID:15491423 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO diflorasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CXCL2 protein] CTD PMID:12956900 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Il4 interleukin 4 multiple interactions ISO diflorasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein] CTD PMID:12956900 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 multiple interactions ISO diflorasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL6 protein] CTD PMID:12956900 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      application 19426
        anti-inflammatory agent 14965
          anti-inflammatory drug 13624
            diflorasone 5
              diflorasone diacetate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      ketone 16173
                                        oxyketone 8635
                                          alpha-oxyketone 8635
                                            alpha-hydroxy ketone 8635
                                              primary alpha-hydroxy ketone 7520
                                                diflorasone 5
                                                  diflorasone diacetate 0
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