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ONTOLOGY REPORT - ANNOTATIONS


Term:2-hydroxy-4-methylvaleric acid
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Accession:CHEBI:59783 term browser browse the term
Definition:A valeric acid derivative having a hydroxy substituent at the 2-position and a methyl substituent at the 4-position; an alpha-hydroxy analogue of leucine. A bacterial metabolite, it has also been isolated from amniotic fluid, was found in a patient with dihydrolipoyl dehydrogenase deficiency and is present in the urine of patients with short bowel syndrome.
Synonyms:related_synonym: 2-Hydroxy-4-methylpentanoic acid;   2-hydroxyisocaproic acid;   2-hydroxyisohexanoic acid;   Formula=C6H12O3;   InChI=1S/C6H12O3/c1-4(2)3-5(7)6(8)9/h4-5,7H,3H2,1-2H3,(H,8,9);   InChIKey=LVRFTAZAXQPQHI-UHFFFAOYSA-N;   Leucic acid;   SMILES=C(C(C(O)=O)O)C(C)C;   alpha-Hydroxyisocaproic acid;   leucinic acid
 xref: CAS:498-36-2 "ChemIDplus";   HMDB:HMDB0000665;   LIPID_MAPS_instance:LMFA01050381 "LIPID MAPS"
 xref_mesh: MESH:C019419
 xref: PMID:17439666 "Europe PMC";   PMID:4018104 "Europe PMC";   PMID:6467607 "Europe PMC";   PMID:6688766 "Europe PMC";   Reaxys:1721733 "Reaxys"
 cyclic_relationship: is_conjugate_acid_of CHEBI:133577


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2-hydroxy-4-methylvaleric acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lepr leptin receptor JBrowse link 5 120,503,475 120,682,281 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19741
    role 19688
      biological role 19686
        biochemical role 19190
          metabolite 19162
            2-hydroxy-4-methylvaleric acid 1
              (R)-2-hydroxy-4-methylpentanoic acid + 0
              (S)-2-hydroxy-4-methylpentanoic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19741
    subatomic particle 19737
      composite particle 19737
        hadron 19737
          baryon 19737
            nucleon 19737
              atomic nucleus 19737
                atom 19737
                  main group element atom 19622
                    p-block element atom 19622
                      carbon group element atom 19515
                        carbon atom 19508
                          organic molecular entity 19508
                            organic group 18423
                              organic divalent group 18414
                                organodiyl group 18414
                                  carbonyl group 18301
                                    carbonyl compound 18301
                                      carboxylic acid 17966
                                        monocarboxylic acid 17265
                                          fatty acid 15813
                                            saturated fatty acid 15781
                                              straight-chain saturated fatty acid 15178
                                                valeric acid 14341
                                                  2-hydroxy-4-methylvaleric acid 1
                                                    (R)-2-hydroxy-4-methylpentanoic acid + 0
                                                    (S)-2-hydroxy-4-methylpentanoic acid 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.