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Term:ketorolac tromethamine
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Accession:CHEBI:6130 term browser browse the term
Definition:An organoammonium salt resulting from the mixture of equimolar amounts of ketorolac and tromethamine (tris). It has potent non-sedating analgesic and moderate anti-inflammatory effects. It is used in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis.
Synonyms:exact_synonym: 1,3-dihydroxy-2-(hydroxymethyl)propan-2-aminium 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylate
 related_synonym: Acular;   Acuvail;   Dolac;   Formula=C19H24N2O6;   InChI=1S/C15H13NO3.C4H11NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13;5-4(1-6,2-7)3-8/h1-7,11H,8-9H2,(H,18,19);6-8H,1-3,5H2;   InChIKey=BWHLPLXXIDYSNW-UHFFFAOYSA-N;   Lixidol;   SMILES=[NH3+]C(CO)(CO)CO.[O-]C(=O)C1CCn2c1ccc2C(=O)c1ccccc1;   Sprix;   Toradol
 xref: CAS:74103-07-4 "ChemIDplus";   CAS:74103-07-4 "KEGG DRUG";   DrugBank:DB00465;   HMDB:HMDB0014608;   KEGG:D00813;   PMID:19663721 "Europe PMC";   PMID:23016110 "Europe PMC";   PMID:23098098 "Europe PMC";   PMID:23199134 "Europe PMC";   PMID:23302965 "Europe PMC";   PMID:23992042 "Europe PMC";   PMID:8863973 "Europe PMC";   Reaxys:6463165 "Reaxys"

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  CHEBI ontology 0
    role 0
      biological role 0
        pharmacological role 0
          analgesic 0
            ketorolac tromethamine 0
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  CHEBI ontology 0
    subatomic particle 0
      composite particle 0
        hadron 0
          baryon 0
            nucleon 0
              atomic nucleus 0
                atom 0
                  main group element atom 0
                    main group molecular entity 0
                      s-block molecular entity 0
                        hydrogen molecular entity 0
                          hydrides 0
                            inorganic hydride 0
                              pnictogen hydride 0
                                nitrogen hydride 0
                                  ammonium 0
                                    ammonium ion derivative 0
                                      ammonium compound 0
                                        organoammonium salt 0
                                          ketorolac tromethamine 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.