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ONTOLOGY REPORT - ANNOTATIONS


Term:afatinib
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Accession:CHEBI:61390 term browser browse the term
Definition:A quinazoline compound having a 3-chloro-4-fluoroanilino group at the 4-position, a 4-dimethylamino-trans-but-2-enamido group at the 6-position, and an (S)-tetrahydrofuran-3-yloxy group at the 7-position. Used (as its dimaleate salt) for the first-line treatment of patients with metastatic non-small cell lung cancer.
Synonyms:exact_synonym: (2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3S)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide
 related_synonym: BIBW 2992;   Formula=C24H25ClFN5O3;   InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1;   InChIKey=ULXXDDBFHOBEHA-CWDCEQMOSA-N;   SMILES=CN(C)C\\C=C\\C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1;   afatinibum
 xref: CAS:850140-72-6 "ChemIDplus";   DrugBank:DB08916;   Drug_Central:4318 "DrugCentral";   KEGG:D09724
 xref_mesh: MESH:C522924
 xref: PDBeChem:0WM;   PMID:21732753 "Europe PMC";   PMID:21737652 "Europe PMC";   PMID:22006669 "Europe PMC";   PMID:22071596 "Europe PMC";   PMID:22200729 "Europe PMC";   PMID:22257651 "Europe PMC";   PMID:22325357 "Europe PMC";   PMID:22418700 "Europe PMC";   PMID:22763464 "Europe PMC";   PMID:22888144 "Europe PMC";   PMID:23161334 "Europe PMC";   PMID:23161335 "Europe PMC";   PMID:23293114 "Europe PMC";   PMID:23443806 "Europe PMC";   PMID:23506519 "Europe PMC";   PMID:23578997 "Europe PMC";   PMID:23664448 "Europe PMC";   PMID:23813493 "Europe PMC";   PMID:23816960 "Europe PMC";   PMID:23816967 "Europe PMC";   PMID:23982599 "Europe PMC";   PMID:24019332 "Europe PMC";   PMID:24085260 "Europe PMC";   Reaxys:11746023 "Reaxys";   Wikipedia:Afatinib


show annotations for term's descendants       view all columns           Sort by:
 
afatinib term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:6480464
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:6480464
G Ehmt2 euchromatic histone lysine methyltransferase 2 JBrowse link 20 4,576,033 4,592,980 RGD:6480464
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:6480464
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:6480464
G Pou5f1 POU class 5 homeobox 1 JBrowse link 20 3,747,231 3,751,994 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19728
    role 19675
      application 19328
        pharmaceutical 19202
          drug 19202
            antineoplastic agent 16877
              afatinib 7
                afatinib dimaleate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    p-block element atom 19610
                      carbon group element atom 19501
                        carbon atom 19494
                          organic molecular entity 19494
                            organic group 18413
                              organic divalent group 18404
                                organodiyl group 18404
                                  carbonyl group 18293
                                    carbonyl compound 18293
                                      carboxylic acid 17960
                                        carboacyl group 17072
                                          univalent carboacyl group 17072
                                            carbamoyl group 16801
                                              carboxamide 16801
                                                alpha,beta-unsaturated carboxylic acid amide 4753
                                                  enamide 4753
                                                    afatinib 7
                                                      afatinib dimaleate 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.