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ONTOLOGY REPORT - ANNOTATIONS


Term:ribavirin
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Accession:CHEBI:63580 term browser browse the term
Definition:A 1-ribosyltriazole that is the 1-ribofuranosyl derivative of 1,2,4-triazole-3-carboxamide. A synthetic guanosine analogue, it is an inhibitor of HCV polymerase and possesses a broad spectrum of activity against DNA and RNA viruses.
Synonyms:related_synonym: 1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide;   1-beta-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide;   Formula=C8H12N4O5;   InChI=1S/C8H12N4O5/c9-6(16)7-10-2-12(11-7)8-5(15)4(14)3(1-13)17-8/h2-5,8,13-15H,1H2,(H2,9,16)/t3-,4-,5-,8-/m1/s1;   InChIKey=IWUCXVSUMQZMFG-AFCXAGJDSA-N;   RBV;   SMILES=NC(=O)c1ncn(n1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O;   ribavirina;   ribavirine;   ribavirinum
 alt_id: CHEBI:8840
 xref: Beilstein:892462 "ChemIDplus";   CAS:36791-04-5 "ChemIDplus";   CAS:36791-04-5 "KEGG DRUG";   DrugBank:DB00811;   Drug_Central:2373 "DrugCentral";   KEGG:D00423;   LINCS:LSM-5701
 xref_mesh: MESH:D012254
 xref: PMID:21827730 "Europe PMC";   PMID:22052088 "Europe PMC";   PMID:22052220 "Europe PMC";   PMID:22156853 "Europe PMC";   PMID:22158703 "Europe PMC";   PMID:22212566 "Europe PMC";   PMID:22212568 "Europe PMC";   PMID:22212569 "Europe PMC";   PMID:22212572 "Europe PMC";   PMID:22212576 "Europe PMC";   PMID:22212579 "Europe PMC";   PMID:22220723 "Europe PMC";   PMID:22239498 "Europe PMC";   PMID:22239511 "Europe PMC";   PMID:29438107 "Europe PMC";   Reaxys:892462 "Reaxys";   Wikipedia:Ribavirin


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ribavirin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AKT1 AKT serine/threonine kinase 1 JBrowse link 14 104,769,349 104,795,748 RGD:6480464
G CASP3 caspase 3 JBrowse link 4 184,627,696 184,649,475 RGD:6480464
G CASP7 caspase 7 JBrowse link 10 113,679,162 113,730,909 RGD:6480464
G CASP8 caspase 8 JBrowse link 2 201,233,443 201,287,711 RGD:6480464
G CCND1 cyclin D1 JBrowse link 11 69,641,156 69,654,474 RGD:6480464
G EIF4E eukaryotic translation initiation factor 4E JBrowse link 4 98,871,684 98,930,637 RGD:6480464
G EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 JBrowse link 8 38,030,534 38,060,365 RGD:6480464
G EPO erythropoietin JBrowse link 7 100,720,468 100,723,700 RGD:6480464
G FAS Fas cell surface death receptor JBrowse link 10 88,968,429 89,017,059 RGD:6480464
G ICAM1 intercellular adhesion molecule 1 JBrowse link 19 10,271,120 10,286,615 RGD:6480464
G IFNA2 interferon alpha 2 JBrowse link 9 21,384,255 21,385,398 RGD:6480464
G IFNG interferon gamma JBrowse link 12 68,154,768 68,159,740 RGD:6480464
G IFNL3 interferon lambda 3 JBrowse link 19 39,243,553 39,245,077 RGD:6480464
G IL10 interleukin 10 JBrowse link 1 206,767,602 206,772,494 RGD:6480464
G IL12A interleukin 12A JBrowse link 3 159,988,835 159,996,019 RGD:6480464
G IL12B interleukin 12B JBrowse link 5 159,314,780 159,330,487 RGD:6480464
G IL1B interleukin 1 beta JBrowse link 2 112,829,751 112,836,843 RGD:6480464
G IL2 interleukin 2 JBrowse link 4 122,449,479 122,456,725 RGD:6480464
G IL4 interleukin 4 JBrowse link 5 132,673,986 132,682,678 RGD:6480464
G IL5 interleukin 5 JBrowse link 5 132,539,194 132,556,864 RGD:6480464
G IL6 interleukin 6 JBrowse link 7 22,725,889 22,732,002 RGD:6480464
G ITPA inosine triphosphatase JBrowse link 20 3,208,676 3,227,449 RGD:6480464
G MTOR mechanistic target of rapamycin kinase JBrowse link 1 11,106,535 11,273,497 RGD:6480464
G MYC MYC proto-oncogene, bHLH transcription factor JBrowse link 8 127,735,434 127,742,951 RGD:6480464
G OAS1 2'-5'-oligoadenylate synthetase 1 JBrowse link 12 112,906,777 112,933,219 RGD:6480464
G SLC29A1 solute carrier family 29 member 1 (Augustine blood group) JBrowse link 6 44,219,587 44,234,144 RGD:6480464
G SLC29A3 solute carrier family 29 member 3 JBrowse link 10 71,319,253 71,363,390 RGD:6480464
G SLC6A4 solute carrier family 6 member 4 JBrowse link 17 30,194,319 30,235,697 RGD:6480464
G TNF tumor necrosis factor JBrowse link 6 31,575,565 31,578,336 RGD:6480464
G TNFSF10 TNF superfamily member 10 JBrowse link 3 172,505,508 172,523,430 RGD:6480464
G TXN thioredoxin JBrowse link 9 110,243,810 110,256,507 RGD:6480464
G VEGFA vascular endothelial growth factor A JBrowse link 6 43,770,209 43,786,487 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 23754
    role 23643
      biological role 23606
        antimicrobial agent 20048
          antiviral agent 3773
            ribavirin 32
Path 2
Term Annotations click to browse term
  CHEBI ontology 23754
    subatomic particle 23703
      composite particle 23703
        hadron 23703
          baryon 23703
            nucleon 23703
              atomic nucleus 23703
                atom 23703
                  main group element atom 23522
                    p-block element atom 23522
                      carbon group element atom 23232
                        carbon atom 23208
                          organic molecular entity 23208
                            organic group 21894
                              organic divalent group 21866
                                organodiyl group 21866
                                  carbonyl group 21838
                                    carbonyl compound 21838
                                      carboxylic acid 20881
                                        carboacyl group 18971
                                          univalent carboacyl group 18971
                                            carbamoyl group 18357
                                              carboxamide 18357
                                                monocarboxylic acid amide 15333
                                                  ribavirin 32
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.