Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:maraviroc
go back to main search page
Accession:CHEBI:63608 term browser browse the term
Definition:A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 4,4-difluorocyclohexanecarboxylic acid and the primary amino group of (1S)-3-[(3-exo)-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropylamine. An antiretroviral drug, it prevents the interaction of HIV-1 gp120 and chemokine receptor 5 (CCR5) necessary for CCR5-tropic HIV-1 to enter cells.
Synonyms:exact_synonym: 4,4-difluoro-N-{(1S)-3-[(3-exo)-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropyl}cyclohexanecarboxamide
 related_synonym: Formula=C29H41F2N5O;   InChI=1S/C29H41F2N5O/c1-19(2)27-34-33-20(3)36(27)25-17-23-9-10-24(18-25)35(23)16-13-26(21-7-5-4-6-8-21)32-28(37)22-11-14-29(30,31)15-12-22/h4-8,19,22-26H,9-18H2,1-3H3,(H,32,37)/t23-,24+,25-,26-/m0/s1;   InChIKey=GSNHKUDZZFZSJB-QYOOZWMWSA-N;   SMILES=CC(C)c1nnc(C)n1[C@H]1C[C@@H]2CC[C@H](C1)N2CC[C@H](NC(=O)C1CCC(F)(F)CC1)c1ccccc1;   maravirocum
 xref: CAS:376348-65-1 "ChemIDplus";   CAS:376348-65-1 "KEGG DRUG";   DrugBank:DB04835;   KEGG:D06670
 xref_mesh: MESH:C502411
 xref: PMID:21134404 "Europe PMC";   PMID:21383098 "Europe PMC";   PMID:21393136 "Europe PMC";   PMID:21505306 "Europe PMC";   PMID:21595497 "Europe PMC";   PMID:21692669 "Europe PMC";   PMID:21987241 "Europe PMC";   PMID:22017448 "Europe PMC";   PMID:22034870 "Europe PMC";   PMID:22064539 "Europe PMC";   PMID:22090117 "Europe PMC";   PMID:22118500 "Europe PMC";   PMID:22174038 "Europe PMC";   PMID:22236118 "Europe PMC";   PMID:22247337 "Europe PMC";   PMID:24419064 "Europe PMC";   PMID:24651825 "Europe PMC";   PMID:24652492 "Europe PMC";   PMID:25017682 "Europe PMC";   Reaxys:10131963 "Reaxys";   Wikipedia:Maraviroc


show annotations for term's descendants       view all columns           Sort by:
 
maraviroc term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Actn2 actinin alpha 2 JBrowse link 17 66,304,530 66,397,647 RGD:6480464
G Ccl3 C-C motif chemokine ligand 3 JBrowse link 10 70,869,516 70,871,066 RGD:6480464
G Ccl5 C-C motif chemokine ligand 5 JBrowse link 10 70,739,764 70,744,303 RGD:6480464
G Ccr5 C-C motif chemokine receptor 5 JBrowse link 8 133,192,398 133,215,599 RGD:6480464
G Col1a1 collagen type I alpha 1 chain JBrowse link 10 82,745,801 82,762,790 RGD:6480464
G Col1a2 collagen type I alpha 2 chain JBrowse link 4 31,534,225 31,569,152 RGD:6480464
G Myh6 myosin heavy chain 6 JBrowse link 15 33,605,653 33,629,730 RGD:6480464
G Ryr2 ryanodine receptor 2 JBrowse link 17 65,533,998 65,955,606 RGD:6480464
G Tnnt2 troponin T2, cardiac type JBrowse link 13 52,662,974 52,680,992 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19741
    role 19688
      biological role 19686
        antimicrobial agent 17215
          antiviral agent 3708
            antiviral drug 1777
              maraviroc 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19741
    subatomic particle 19737
      composite particle 19737
        hadron 19737
          baryon 19737
            nucleon 19737
              atomic nucleus 19737
                atom 19737
                  main group element atom 19622
                    p-block element atom 19622
                      carbon group element atom 19515
                        carbon atom 19508
                          organic molecular entity 19508
                            organic group 18423
                              organic divalent group 18414
                                organodiyl group 18414
                                  carbonyl group 18301
                                    carbonyl compound 18301
                                      carboxylic acid 17966
                                        carboacyl group 17073
                                          univalent carboacyl group 17073
                                            carbamoyl group 16800
                                              carboxamide 16800
                                                monocarboxylic acid amide 14162
                                                  maraviroc 9
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.