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ONTOLOGY REPORT - ANNOTATIONS


Term:misoprostol
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Accession:CHEBI:63610 term browser browse the term
Definition:A diastereoisomeric mixture composed of approximately equal amounts of a double racemate of four of the sixteen possible diastereoisomers of methyl (13E)-11,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oate that is racemic prostaglandin E1 which is lacking the hydroxy group at position 15, but which has an additional hydroxy group at position 16. It is a synthetic prostaglandin E1 analogue, used in the treatment of gastric and duodenal ulcers. A weak abortifacient, it is also used for cervical ripening prior to surgical termination of pregnancy. The (11R,16S)-diastereoisomer is the pharmacologically active form.
Synonyms:related_synonym: (+-)-methyl (1R,2R,3R)-3-hydroxy-2-((E)-(4RS)-4-hydroxy-4-methyl-1-octenyl)-5-oxocyclopentaneheptanoate;   (11-alpha,13E)-(+-)-11,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oic acid methyl ester;   Arthrotec;   Cytotec;   Methyl (+-)-11-alpha,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oate;   misoprostolum
 alt_id: CHEBI:6952
 xref: CAS:59122-46-2 "ChemIDplus";   CAS:59122-46-2 "KEGG DRUG";   DrugBank:DB00929;   KEGG:D00419
 xref_mesh: MESH:D016595
 xref: PMID:10945193 "Europe PMC";   PMID:10949752 "Europe PMC";   PMID:11136959 "Europe PMC";   PMID:1417145 "Europe PMC";   PMID:18690850 "Europe PMC";   PMID:19740175 "Europe PMC";   PMID:2109814 "Europe PMC";   PMID:3080288 "Europe PMC";   Patent:BE827127;   Patent:US3965143;   Reaxys:4155643 "Reaxys";   Wikipedia:Misoprostol


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misoprostol term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adcyap1 adenylate cyclase activating polypeptide 1 JBrowse link 9 121,705,897 121,725,736 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:6480464
G Chrm1 cholinergic receptor, muscarinic 1 JBrowse link 1 224,869,087 224,885,101 RGD:6480464
G Gast gastrin JBrowse link 10 88,245,532 88,248,485 RGD:6480464
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il23a interleukin 23 subunit alpha JBrowse link 7 2,710,609 2,712,723 RGD:6480464
G Ptger1 prostaglandin E receptor 1 JBrowse link 19 24,799,422 24,803,373 RGD:6480464
G Ptger2 prostaglandin E receptor 2 JBrowse link 15 19,336,029 19,349,759 RGD:6480464
G Ptger3 prostaglandin E receptor 3 JBrowse link 2 263,895,093 263,979,682 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Tac1 tachykinin, precursor 1 JBrowse link 4 33,638,853 33,646,819 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19748
    chemical entity 19746
      chemical substance 11490
        mixture 10810
          diastereoisomeric mixture 420
            misoprostol 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19748
    subatomic particle 19744
      composite particle 19744
        hadron 19744
          baryon 19744
            nucleon 19744
              atomic nucleus 19744
                atom 19744
                  main group element atom 19628
                    p-block element atom 19628
                      chalcogen 19337
                        oxygen atom 19298
                          oxygen molecular entity 19298
                            hydroxides 19053
                              organic hydroxy compound 18626
                                alcohol 14947
                                  aliphatic alcohol 11082
                                    alkyl alcohol 11036
                                      methanol 2975
                                        methyl ester 2966
                                          methyl (13E)-11,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oate 15
                                            (11R,16S)-misoprostol 15
                                              misoprostol 15
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