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ONTOLOGY REPORT - ANNOTATIONS


Term:tenofovir (anhydrous)
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Accession:CHEBI:63625 term browser browse the term
Definition:A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens is replaced by a [(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(isopropyloxycarbonyloxymethyl) ester (disoproxil ester) prodrug is used as the fumaric acid salt in combination therapy for the treatment of HIV infection.
Synonyms:exact_synonym: ({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphonic acid
 related_synonym: (R)-PMPA;   Formula=C9H14N5O4P;   InChI=1S/C9H14N5O4P/c1-6(18-5-19(15,16)17)2-14-4-13-7-8(10)11-3-12-9(7)14/h3-4,6H,2,5H2,1H3,(H2,10,11,12)(H2,15,16,17)/t6-/m1/s1;   InChIKey=SGOIRFVFHAKUTI-ZCFIWIBFSA-N;   SMILES=C[C@H](Cn1cnc2c(N)ncnc12)OCP(O)(O)=O;   anh. tenofovir;   tenofovir
 xref: CAS:147127-20-6 "ChemIDplus";   DrugBank:DB00300;   HMDB:HMDB0014445;   KEGG:D06074;   LINCS:LSM-5340;   PMID:11777298 "Europe PMC";   PMID:25017682 "Europe PMC";   PMID:28166217 "Europe PMC";   PMID:28503983 "Europe PMC";   Reaxys:7415378 "Reaxys";   Wikipedia:Tenofovir
 cyclic_relationship: is_conjugate_acid_of CHEBI:134504


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Term Annotations click to browse term
  CHEBI ontology 0
    role 0
      biological role 0
        antimicrobial agent 0
          antiviral agent 0
            antiviral drug 0
              tenofovir (anhydrous) 0
                tenofovir disoproxil + 0
                tenofovir hydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 0
    subatomic particle 0
      composite particle 0
        hadron 0
          baryon 0
            nucleon 0
              atomic nucleus 0
                atom 0
                  main group element atom 0
                    p-block element atom 0
                      carbon group element atom 0
                        carbon atom 0
                          organic molecular entity 0
                            heteroorganic entity 0
                              organochalcogen compound 0
                                organooxygen compound 0
                                  carbohydrates and carbohydrate derivatives 0
                                    carbohydrate 0
                                      carbohydrate derivative 0
                                        glycosyl compound 0
                                          N-glycosyl compound 0
                                            nucleoside analogue 0
                                              tenofovir (anhydrous) 0
                                                tenofovir disoproxil + 0
                                                tenofovir hydrate 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.