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Term:tenofovir (anhydrous)
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Accession:CHEBI:63625 term browser browse the term
Definition:A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens is replaced by a [(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(isopropyloxycarbonyloxymethyl) ester (disoproxil ester) prodrug is used as the fumaric acid salt in combination therapy for the treatment of HIV infection.
Synonyms:exact_synonym: ({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphonic acid
 related_synonym: (R)-PMPA;   Formula=C9H14N5O4P;   InChI=1S/C9H14N5O4P/c1-6(18-5-19(15,16)17)2-14-4-13-7-8(10)11-3-12-9(7)14/h3-4,6H,2,5H2,1H3,(H2,10,11,12)(H2,15,16,17)/t6-/m1/s1;   InChIKey=SGOIRFVFHAKUTI-ZCFIWIBFSA-N;   SMILES=C[C@H](Cn1cnc2c(N)ncnc12)OCP(O)(O)=O;   anh. tenofovir;   tenofovir
 xref: CAS:147127-20-6 "ChemIDplus";   DrugBank:DB00300;   HMDB:HMDB0014445;   KEGG:D06074;   LINCS:LSM-5340;   PMID:11777298 "Europe PMC";   PMID:25017682 "Europe PMC";   PMID:28166217 "Europe PMC";   PMID:28503983 "Europe PMC";   Reaxys:7415378 "Reaxys";   Wikipedia:Tenofovir
 cyclic_relationship: is_conjugate_acid_of CHEBI:134504

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  CHEBI ontology 225
    role 225
      biological role 225
        antimicrobial agent 108
          antiviral agent 11
            antiviral drug 9
              tenofovir (anhydrous) 0
                tenofovir disoproxil + 0
                tenofovir hydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 225
    subatomic particle 225
      composite particle 225
        hadron 225
          baryon 225
            nucleon 225
              atomic nucleus 225
                atom 225
                  main group element atom 218
                    p-block element atom 218
                      carbon group element atom 207
                        carbon atom 206
                          organic molecular entity 206
                            heteroorganic entity 200
                              organochalcogen compound 169
                                organooxygen compound 168
                                  carbohydrates and carbohydrate derivatives 38
                                    carbohydrate 38
                                      carbohydrate derivative 33
                                        glycosyl compound 29
                                          N-glycosyl compound 5
                                            nucleoside analogue 0
                                              tenofovir (anhydrous) 0
                                                tenofovir disoproxil + 0
                                                tenofovir hydrate 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.