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ONTOLOGY REPORT - ANNOTATIONS


Term:tipranavir
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Accession:CHEBI:63628 term browser browse the term
Definition:A pyridine-2-sulfonamide substituted at C-5 by a trifluoromethyl group and at the sulfonamide nitrogen by a dihydropyrone-containing m-tolyl substituent. It is an HIV-1 protease inhibitor.
Synonyms:exact_synonym: N-(3-{(1R)-1-[(6R)-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-5,6-dihydro-2H-pyran-3-yl]propyl}phenyl)-5-(trifluoromethyl)pyridine-2-sulfonamide
 related_synonym: 3'-((1R)-1-((6R)-5,6-Dihydro-4-hydroxy-2-oxo-6-phenethyl-6-propyl-2H-pyran-3-yl)propyl)-5-(trifluoromethyl)-2-pyridinesulfonanilide;   Formula=C31H33F3N2O5S;   InChI=1S/C31H33F3N2O5S/c1-3-16-30(17-15-21-9-6-5-7-10-21)19-26(37)28(29(38)41-30)25(4-2)22-11-8-12-24(18-22)36-42(39,40)27-14-13-23(20-35-27)31(32,33)34/h5-14,18,20,25,36-37H,3-4,15-17,19H2,1-2H3/t25-,30-/m1/s1;   InChIKey=SUJUHGSWHZTSEU-FYBSXPHGSA-N;   SMILES=CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(cn3)C(F)(F)F)c2)C(=O)O1
 xref: CAS:174484-41-4 "ChemIDplus";   DrugBank:DB00932;   KEGG:D08605
 xref_mesh: MESH:C107201
 xref: PMID:17620375 "Europe PMC";   PMID:20368406 "Europe PMC";   PMID:21041916 "Europe PMC";   PMID:21571982 "Europe PMC";   PMID:21576452 "Europe PMC";   PMID:21825300 "Europe PMC";   PMID:21871444 "Europe PMC";   PMID:22007990 "Europe PMC";   PMID:22096044 "Europe PMC";   PMID:22258921 "Europe PMC";   PMID:25017682 "Europe PMC";   Reaxys:7698323 "Reaxys"


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tipranavir term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb11 ATP binding cassette subfamily B member 11 JBrowse link 3 55,480,024 55,587,946 RGD:6480464
G Abcb4 ATP binding cassette subfamily B member 4 JBrowse link 4 22,133,984 22,192,687 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19728
    role 19675
      biological role 19673
        antimicrobial agent 17211
          antiviral agent 3709
            antiviral drug 1776
              tipranavir 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    p-block element atom 19610
                      chalcogen 19322
                        oxygen atom 19283
                          oxygen molecular entity 19283
                            hydroxides 19042
                              oxoacid 18106
                                chalcogen oxoacid 11403
                                  sulfur oxoacid 10994
                                    sulfonic acid 7253
                                      sulfonic acid derivative 7253
                                        sulfonamide 3125
                                          tipranavir 2
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