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ONTOLOGY REPORT - ANNOTATIONS


Term:topotecan
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Accession:CHEBI:63632 term browser browse the term
Definition:A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks.
Synonyms:exact_synonym: (4S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
 related_synonym: 9-[(dimethylamino)methyl]-10-hydroxy-(4S)-camptothecin;   Formula=C23H23N3O5;   InChI=1S/C23H23N3O5/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20/h5-8,27,30H,4,9-11H2,1-3H3/t23-/m0/s1;   InChIKey=UCFGDBYHRUNTLO-QHCPKHFHSA-N;   SMILES=CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccc(O)c(CN(C)C)c4cc3Cn1c2=O;   topotecane;   topotecanum
 alt_id: CHEBI:9634
 xref: CAS:123948-87-8 "ChemIDplus";   CAS:123948-87-8 "KEGG COMPOUND";   DrugBank:DB01030;   KEGG:C11158;   KEGG:D08618;   LINCS:LSM-5662
 xref_mesh: MESH:D019772
 xref: PDBeChem:TTC;   PMID:20574789 "Europe PMC";   PMID:21255983 "Europe PMC";   PMID:21352915 "Europe PMC";   PMID:21910214 "Europe PMC";   PMID:22028494 "Europe PMC";   PMID:22075006 "Europe PMC";   PMID:22136714 "Europe PMC";   PMID:22190039 "Europe PMC";   Patent:EP321122;   Reaxys:4279441 "Reaxys";   Wikipedia:Topotecan


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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19741
    role 19688
      application 19339
        pharmaceutical 19214
          drug 19214
            antineoplastic agent 16873
              topotecan 2691
Path 2
Term Annotations click to browse term
  CHEBI ontology 19741
    subatomic particle 19737
      composite particle 19737
        hadron 19737
          baryon 19737
            nucleon 19737
              atomic nucleus 19737
                atom 19737
                  main group element atom 19622
                    p-block element atom 19622
                      carbon group element atom 19515
                        carbon atom 19508
                          organic molecular entity 19508
                            organic molecule 19431
                              organic cyclic compound 19197
                                organic heterocyclic compound 18267
                                  organic heteropolycyclic compound 17574
                                    organic heteropentacyclic compound 13163
                                      pyranoindolizinoquinoline 3206
                                        topotecan 2691
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