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ONTOLOGY REPORT - ANNOTATIONS


Term:topotecan
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Accession:CHEBI:63632 term browser browse the term
Definition:A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks.
Synonyms:exact_synonym: (4S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
 related_synonym: 9-[(dimethylamino)methyl]-10-hydroxy-(4S)-camptothecin;   Formula=C23H23N3O5;   InChI=1S/C23H23N3O5/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20/h5-8,27,30H,4,9-11H2,1-3H3/t23-/m0/s1;   InChIKey=UCFGDBYHRUNTLO-QHCPKHFHSA-N;   SMILES=CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccc(O)c(CN(C)C)c4cc3Cn1c2=O;   topotecane;   topotecanum
 alt_id: CHEBI:9634
 xref: CAS:123948-87-8 "ChemIDplus";   CAS:123948-87-8 "KEGG COMPOUND";   DrugBank:DB01030;   KEGG:C11158;   KEGG:D08618;   LINCS:LSM-5662
 xref_mesh: MESH:D019772
 xref: PDBeChem:TTC;   PMID:20574789 "Europe PMC";   PMID:21255983 "Europe PMC";   PMID:21352915 "Europe PMC";   PMID:21910214 "Europe PMC";   PMID:22028494 "Europe PMC";   PMID:22075006 "Europe PMC";   PMID:22136714 "Europe PMC";   PMID:22190039 "Europe PMC";   Patent:EP321122;   Reaxys:4279441 "Reaxys";   Wikipedia:Topotecan


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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 23757
    role 23646
      application 23042
        pharmaceutical 22594
          drug 22594
            antineoplastic agent 18962
              topotecan 2674
Path 2
Term Annotations click to browse term
  CHEBI ontology 23757
    subatomic particle 23706
      composite particle 23706
        hadron 23706
          baryon 23706
            nucleon 23706
              atomic nucleus 23706
                atom 23706
                  main group element atom 23525
                    p-block element atom 23525
                      carbon group element atom 23236
                        carbon atom 23213
                          organic molecular entity 23213
                            organic molecule 23075
                              organic cyclic compound 22093
                                organic heterocyclic compound 20730
                                  organic heteropolycyclic compound 19852
                                    organic heteropentacyclic compound 14752
                                      pyranoindolizinoquinoline 3219
                                        topotecan 2674
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.