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ONTOLOGY REPORT - ANNOTATIONS


Term:topotecan
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Accession:CHEBI:63632 term browser browse the term
Definition:A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks.
Synonyms:exact_synonym: (4S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
 related_synonym: 9-[(dimethylamino)methyl]-10-hydroxy-(4S)-camptothecin;   Formula=C23H23N3O5;   InChI=1S/C23H23N3O5/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20/h5-8,27,30H,4,9-11H2,1-3H3/t23-/m0/s1;   InChIKey=UCFGDBYHRUNTLO-QHCPKHFHSA-N;   SMILES=CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccc(O)c(CN(C)C)c4cc3Cn1c2=O;   topotecane;   topotecanum
 alt_id: CHEBI:9634
 xref: CAS:123948-87-8 "ChemIDplus";   CAS:123948-87-8 "KEGG COMPOUND";   DrugBank:DB01030;   KEGG:C11158;   KEGG:D08618;   LINCS:LSM-5662
 xref_mesh: MESH:D019772
 xref: PDBeChem:TTC;   PMID:20574789 "Europe PMC";   PMID:21255983 "Europe PMC";   PMID:21352915 "Europe PMC";   PMID:21910214 "Europe PMC";   PMID:22028494 "Europe PMC";   PMID:22075006 "Europe PMC";   PMID:22136714 "Europe PMC";   PMID:22190039 "Europe PMC";   Patent:EP321122;   Reaxys:4279441 "Reaxys";   Wikipedia:Topotecan


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Path 1
Term Annotations click to browse term
  CHEBI ontology 21038
    role 21018
      application 20451
        pharmaceutical 20063
          drug 20063
            antineoplastic agent 17316
              topotecan 2667
Path 2
Term Annotations click to browse term
  CHEBI ontology 21038
    subatomic particle 21032
      composite particle 21032
        hadron 21032
          baryon 21032
            nucleon 21032
              atomic nucleus 21032
                atom 21032
                  main group element atom 20874
                    p-block element atom 20874
                      carbon group element atom 20609
                        carbon atom 20586
                          organic molecular entity 20586
                            organic molecule 20440
                              organic cyclic compound 20124
                                organic heterocyclic compound 18979
                                  organic heteropolycyclic compound 18403
                                    organic heteropentacyclic compound 13272
                                      pyranoindolizinoquinoline 3192
                                        topotecan 2667
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