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ONTOLOGY REPORT - ANNOTATIONS


Term:EC 2.1.2.2 (phosphoribosylglycinamide formyltransferase) inhibitor
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Accession:CHEBI:63721 term browser browse the term
Definition:An EC 2.1.2.* (hydroxymethyl-, formyl- and related transferases) inhibitor that interferes with the action of phosphoribosylglycinamide formyltransferase (EC 2.1.2.2).
Synonyms:related_synonym: 10-formyltetrahydrofolate:5'-phosphoribosylglycinamide N-formyltransferase inhibitors;   2-amino-N-ribosylacetamide 5'-phosphate transformylase inhibitor;   5,10-methenyltetrahydrofolate:2-amino-N-ribosylacetamide ribonucleotide transformylase inhibitor;   5,10-methenyltetrahydrofolate:2-amino-N-ribosylacetamide ribonucleotide transformylase inhibitors;   EC 2.1.2.2 inhibitor;   EC 2.1.2.2 inhibitors;   GAR TFase inhibitor;   GAR TFase inhibitors;   GAR formyltransferase inhibitor;   GAR formyltransferase inhibitors;   GAR transformylase inhibitor;   GAR transformylase inhibitors;   glycinamide ribonucleotide formyltransferase inhibitor;   glycinamide ribonucleotide formyltransferase inhibitors;   glycinamide ribonucleotide transformylase inhibitor;   glycinamide ribonucleotide transformylase inhibitors;   phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) inhibitors;   phosphoribosylglycinamide formyltransferase inhibitor;   phosphoribosylglycinamide formyltransferase inhibitors
 xref: Wikipedia:Phosphoribosylglycinamide_formyltransferase


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pemetrexed term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc5 ATP binding cassette subfamily C member 5 JBrowse link 11 84,395,982 84,490,215 RGD:6480464
G Alk ALK receptor tyrosine kinase JBrowse link 6 22,696,415 23,203,791 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Bid BH3 interacting domain death agonist JBrowse link 4 153,439,812 153,465,247 RGD:6480464
G C3 complement C3 JBrowse link 9 9,721,137 9,747,084 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Cflar CASP8 and FADD-like apoptosis regulator JBrowse link 9 65,534,608 65,586,395 RGD:6480464
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 7 70,578,564 70,585,074 RGD:6480464
G Dhfr dihydrofolate reductase JBrowse link 2 21,931,887 21,958,927 RGD:6480464
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit JBrowse link 1 80,256,973 80,268,198 RGD:6480464
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:6480464
G Fpgs folylpolyglutamate synthase JBrowse link 3 11,717,667 11,729,694 RGD:6480464
G Ggh gamma-glutamyl hydrolase JBrowse link 5 34,040,258 34,063,369 RGD:6480464
G Ifi30 IFI30, lysosomal thiol reductase JBrowse link 16 20,426,566 20,430,772 RGD:6480464
G Il11 interleukin 11 JBrowse link 1 72,636,959 72,643,255 RGD:6480464
G Il13ra2 interleukin 13 receptor subunit alpha 2 JBrowse link X 118,443,955 118,514,716 RGD:6480464
G Il1a interleukin 1 alpha JBrowse link 3 121,824,712 121,836,122 RGD:6480464
G Il1rl1 interleukin 1 receptor-like 1 JBrowse link 9 47,133,483 47,184,316 RGD:6480464
G Il33 interleukin 33 JBrowse link 1 248,112,611 248,147,030 RGD:6480464
G Il7r interleukin 7 receptor RGD:6480464
G Klrc1 killer cell lectin like receptor C1 JBrowse link 4 163,453,435 163,463,718 RGD:6480464
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:6480464
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase JBrowse link 4 115,004,433 115,015,965 RGD:6480464
G Npm1 nucleophosmin 1 JBrowse link 10 18,080,949 18,091,062 RGD:6480464
G Nras NRAS proto-oncogene, GTPase JBrowse link 2 205,553,119 205,563,716 RGD:6480464
G Rbm17 RNA binding motif protein 17 JBrowse link 17 70,586,345 70,603,289 RGD:6480464
G Slc19a1 solute carrier family 19 member 1 JBrowse link 20 12,334,675 12,354,517 RGD:6480464
G Slc46a1 solute carrier family 46 member 1 JBrowse link 10 65,728,508 65,741,708 RGD:6480464
G Tnfaip3 TNF alpha induced protein 3 JBrowse link 1 14,401,103 14,416,369 RGD:6480464
G Tnfrsf9 TNF receptor superfamily member 9 JBrowse link 5 168,009,245 168,035,813 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Traf1 TNF receptor-associated factor 1 JBrowse link 3 14,003,340 14,022,955 RGD:6480464
G Tymp thymidine phosphorylase JBrowse link 7 130,342,481 130,347,845 RGD:6480464
G Tyms thymidylate synthetase JBrowse link 9 121,918,875 121,931,564 RGD:6480464

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  CHEBI ontology 19754
    role 19701
      biological role 19700
        biochemical role 19201
          enzyme inhibitor 18093
            EC 2.* (transferase) inhibitor 13531
              EC 2.1.* (C1-transferase) inhibitor 1366
                EC 2.1.2.* (hydroxymethyl-, formyl- and related transferases) inhibitor 864
                  EC 2.1.2.2 (phosphoribosylglycinamide formyltransferase) inhibitor 36
                    pemetrexed 36
                    pemetrexed disodium + 0
                    pemetrexed disodium heptahydrate 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.