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ONTOLOGY REPORT - ANNOTATIONS


Term:riddelliine
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Accession:CHEBI:63924 term browser browse the term
Definition:A macrolide that is 13,19-didehydrosenecionan bearing two additional hydroxy substituents at positions 12 and 18 as well as two additional oxo groups at positions 11 and 16.
Synonyms:exact_synonym: (15Z)-12,18-dihydroxy-13,19-didehydrosenecionan-11,16-dione
 related_synonym: 18-Hydroxyseneciphylline;   Formula=C18H23NO6;   InChI=1S/C18H23NO6/c1-3-12-8-11(2)18(23,10-20)17(22)24-9-13-4-6-19-7-5-14(15(13)19)25-16(12)21/h3-4,14-15,20,23H,2,5-10H2,1H3/b12-3-/t14-,15-,18-/m1/s1;   InChIKey=SVCNNZDUGWLODJ-RAYFHMIRSA-N;   Riddeliin;   Riddeliine;   Riddelline;   SMILES=[H][C@@]12[C@H]3CCN1CC=C2COC(=O)[C@@](O)(CO)C(=C)C\\C(=C\\C)C(=O)O3
 xref: CAS:23246-96-0 "ChemIDplus";   CAS:23246-96-0 "KEGG COMPOUND";   CAS:23246-96-0 "NIST Chemistry WebBook";   KEGG:C10375;   KNApSAcK:C00002110
 xref_mesh: MESH:C013672
 xref: PMID:11170513 "Europe PMC";   PMID:12140173 "Europe PMC";   PMID:14580895 "Europe PMC";   PMID:18842697 "Europe PMC";   PMID:19412857 "Europe PMC";   PMID:1949039 "Europe PMC";   PMID:20078085 "Europe PMC";   PMID:20737008 "Europe PMC";   PMID:2083039 "Europe PMC";   PMID:21170807 "Europe PMC";   PMID:21822322 "Europe PMC";   PMID:21976715 "Europe PMC";   PMID:3507253 "Europe PMC";   Reaxys:1042830 "Reaxys";   Wikipedia:Riddelliine


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riddelliine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
G Abcb9 ATP binding cassette subfamily B member 9 JBrowse link 12 37,923,974 37,956,678 RGD:6480464
G Abcc3 ATP binding cassette subfamily C member 3 JBrowse link 10 82,047,308 82,116,928 RGD:6480464
G Abcc8 ATP binding cassette subfamily C member 8 JBrowse link 1 102,110,708 102,191,287 RGD:6480464
G Abcc9 ATP binding cassette subfamily C member 9 JBrowse link 4 176,806,098 176,928,540 RGD:6480464
G Adm adrenomedullin JBrowse link 1 175,443,189 175,447,260 RGD:6480464
G Ahr aryl hydrocarbon receptor JBrowse link 6 54,963,990 55,001,806 RGD:6480464
G Atp13a5 ATPase 13A5 JBrowse link 11 74,984,538 75,124,249 RGD:6480464
G Ces2h carboxylesterase 2H JBrowse link 19 37,052,555 37,067,176 RGD:6480464
G Cxcr1 C-X-C motif chemokine receptor 1 JBrowse link 9 81,466,430 81,469,299 RGD:6480464
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 JBrowse link 1 256,382,861 256,386,729 RGD:6480464
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 JBrowse link 1 257,676,172 258,004,428 RGD:6480464
G Cyp2c12 cytochrome P450, family 2, subfamily c, polypeptide 12 JBrowse link 1 258,709,726 258,766,873 RGD:6480464
G Cyp2c13 cytochrome P450, family 2, subfamily c, polypeptide 13 JBrowse link 1 258,796,624 258,877,023 RGD:6480464
G Cyp2c22 cytochrome P450, family 2, subfamily c, polypeptide 22 JBrowse link 1 259,257,658 259,297,270 RGD:6480464
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 JBrowse link 1 213,511,892 213,522,195 RGD:6480464
G Cyp3a18 cytochrome P450, family 3, subfamily a, polypeptide 18 JBrowse link 12 10,636,294 10,684,273 RGD:6480464
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 JBrowse link 12 11,641,500 11,677,818 RGD:6480464
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 JBrowse link 12 19,074,288 19,114,491 RGD:6480464
G Cyp4a8 cytochrome P450, family 4, subfamily a, polypeptide 8 JBrowse link 5 133,978,953 134,008,255 RGD:6480464
G Egr1 early growth response 1 JBrowse link 18 27,657,903 27,660,101 RGD:6480464
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 JBrowse link 7 94,479,931 94,563,086 RGD:6480464
G F11r F11 receptor JBrowse link 13 89,826,272 89,850,151 RGD:6480464
G F3 coagulation factor III, tissue factor JBrowse link 2 225,310,686 225,322,281 RGD:6480464
G F7 coagulation factor VII JBrowse link 16 81,824,610 81,834,923 RGD:6480464
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:6480464
G Fmo5 flavin containing dimethylaniline monoxygenase 5 JBrowse link 2 199,796,870 199,823,927 RGD:6480464
G Gsta3 glutathione S-transferase alpha 3 JBrowse link 9 27,357,490 27,417,023 RGD:6480464
G Gstm1 glutathione S-transferase mu 1 JBrowse link 2 210,803,869 210,809,461 RGD:6480464
G Gstm2 glutathione S-transferase mu 2 JBrowse link 2 210,778,041 210,782,807 RGD:6480464
G Hgf hepatocyte growth factor JBrowse link 4 15,435,460 15,505,377 RGD:6480464
G Igfbp1 insulin-like growth factor binding protein 1 JBrowse link 14 87,448,716 87,453,783 RGD:6480464
G Igfbp2 insulin-like growth factor binding protein 2 JBrowse link 9 80,118,029 80,144,804 RGD:6480464
G Il11 interleukin 11 JBrowse link 1 72,636,959 72,643,255 RGD:6480464
G Il15 interleukin 15 JBrowse link 19 23,542,606 23,624,366 RGD:6480464
G Il7 interleukin 7 JBrowse link 2 96,427,884 96,474,979 RGD:6480464
G Inmt indolethylamine N-methyltransferase JBrowse link 4 85,381,907 85,386,203 RGD:6480464
G Itga4 integrin subunit alpha 4 JBrowse link 3 66,178,745 66,265,547 RGD:6480464
G Itga6 integrin subunit alpha 6 JBrowse link 3 58,442,904 58,515,124 RGD:6480464
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:6480464
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:6480464
G Lepr leptin receptor JBrowse link 5 120,503,475 120,682,281 RGD:6480464
G Mmp7 matrix metallopeptidase 7 JBrowse link 8 5,893,253 5,900,965 RGD:6480464
G Mt1 metallothionein 1 JBrowse link 19 11,301,991 11,303,007 RGD:6480464
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase JBrowse link 4 115,004,433 115,015,965 RGD:6480464
G Nqo1 NAD(P)H quinone dehydrogenase 1 JBrowse link 19 38,422,210 38,437,103 RGD:6480464
G Pparg peroxisome proliferator-activated receptor gamma JBrowse link 4 147,274,055 147,399,383 RGD:6480464
G Prkca protein kinase C, alpha JBrowse link 10 96,186,509 96,585,168 RGD:6480464
G Prkcz protein kinase C, zeta JBrowse link 5 172,658,071 172,769,492 RGD:6480464
G Ren renin JBrowse link 13 50,502,724 50,513,953 RGD:6480464
G S1pr2 sphingosine-1-phosphate receptor 2 JBrowse link 8 21,984,914 21,995,806 RGD:6480464
G Slc13a5 solute carrier family 13 member 5 JBrowse link 10 58,806,581 58,835,549 RGD:6480464
G Slc16a4 solute carrier family 16, member 4 JBrowse link 2 210,045,122 210,161,017 RGD:6480464
G Slc22a6 solute carrier family 22 member 6 JBrowse link 1 224,824,809 224,833,284 RGD:6480464
G Slc22a8 solute carrier family 22 member 8 JBrowse link 1 224,799,444 224,818,482 RGD:6480464
G Slc25a21 solute carrier family 25 member 21 JBrowse link 6 77,624,384 78,121,339 RGD:6480464
G Slc25a30 solute carrier family 25, member 30 JBrowse link 15 57,811,612 57,834,173 RGD:6480464
G Slc7a5 solute carrier family 7 member 5 JBrowse link 19 54,693,959 54,722,563 RGD:6480464
G Src SRC proto-oncogene, non-receptor tyrosine kinase JBrowse link 3 153,547,807 153,595,643 RGD:6480464
G Sult1c3 sulfotransferase family 1C member 3 JBrowse link 9 4,931,038 4,978,847 RGD:6480464
G Tgfa transforming growth factor alpha JBrowse link 4 117,961,877 118,045,923 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tnfsf10 TNF superfamily member 10 JBrowse link 2 113,008,008 113,026,899 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        aetiopathogenetic role 18766
          genotoxin 16034
            riddelliine 64
              riddelliine N-oxide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      carboxylic ester 13934
                                        lactone 5859
                                          macrocyclic lactone 1515
                                            macrolide 1454
                                              riddelliine 64
                                                riddelliine N-oxide 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.