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ONTOLOGY REPORT - ANNOTATIONS


Term:ionomycin
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Accession:CHEBI:63954 term browser browse the term
Definition:A very long-chain fatty acid that is docosa-10,16-dienoic acid which is substituted by methyl groups at positions 4, 6, 8, 12, 14, 18 and 20, by hydroxy groups at positions 11, 19 and 21, and by a (2',5-dimethyloctahydro-2,2'-bifuran-5-yl)ethanol group at position 21. An ionophore produced by Streptomyces conglobatus, it is used in research to raise the intracellular level of Ca(2+) and as a research tool to understand Ca(2+) transport across biological membranes.
Synonyms:exact_synonym: (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-trihydroxy-22-{(2S,2'R,5S,5'S)-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyloctahydro-2,2'-bifuran-5-yl}-4,6,8,12,14,18,20-heptamethyl-9-oxodocosa-10,16-dienoic acid
 related_synonym: Formula=C41H72O9;   InChI=1S/C41H72O9/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47)/b13-11+,34-24-/t25-,26-,27+,28-,29-,30+,31+,32-,33+,36+,37-,39-,40+,41+/m1/s1;   InChIKey=PGHMRUGBZOYCAA-ADZNBVRBSA-N;   SMILES=[H][C@]1(CC[C@](C)(O1)[C@@]1([H])CC[C@](C)(O1)[C@@H](C)O)C[C@H](O)[C@H](C)[C@H](O)[C@H](C)\\C=C\\C[C@@H](C)C[C@@H](C)C(\\O)=C\\C(=O)[C@@H](C)C[C@@H](C)C[C@H](C)CCC(O)=O
 xref: CAS:56092-81-0 "ChemIDplus"
 xref_mesh: MESH:D015759
 xref: PMID:19079959 "Europe PMC";   PMID:19496091 "Europe PMC";   Patent:US3873693;   Reaxys:3642126 "Reaxys"


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ionomycin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Actb actin, beta JBrowse link 5 142,903,115 142,907,976 RGD:6480464
G Actn1 actinin, alpha 1 JBrowse link 12 80,167,542 80,260,425 RGD:6480464
G Adm adrenomedullin JBrowse link 7 110,627,657 110,629,820 RGD:6480464
G Ahr aryl-hydrocarbon receptor JBrowse link 12 35,497,979 35,534,989 RGD:6480464
G Akt1 thymoma viral proto-oncogene 1 JBrowse link 12 112,653,821 112,674,884 RGD:6480464
G Arpc2 actin related protein 2/3 complex, subunit 2 JBrowse link 1 74,236,490 74,268,209 RGD:6480464
G Atf4 activating transcription factor 4 JBrowse link 15 80,255,184 80,257,545 RGD:6480464
G Atp2a3 ATPase, Ca++ transporting, ubiquitous JBrowse link 11 72,961,169 72,993,043 RGD:6480464
G Bach2 BTB and CNC homology, basic leucine zipper transcription factor 2 JBrowse link 4 32,238,413 32,586,109 RGD:6480464
G Bcl2a1b B cell leukemia/lymphoma 2 related protein A1b JBrowse link 9 89,199,273 89,207,838 RGD:6480464
G C5ar1 complement component 5a receptor 1 JBrowse link 7 16,246,743 16,259,540 RGD:6480464
G Calca calcitonin/calcitonin-related polypeptide, alpha JBrowse link 7 114,625,981 114,636,910 RGD:6480464
G Calr calreticulin JBrowse link 8 84,842,088 84,846,931 RGD:6480464
G Camk2a calcium/calmodulin-dependent protein kinase II alpha JBrowse link 18 60,925,307 60,988,152 RGD:6480464
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2, beta JBrowse link 5 122,718,380 122,779,522 RGD:6480464
G Casp3 caspase 3 JBrowse link 8 46,617,291 46,639,698 RGD:6480464
G Casp8 caspase 8 JBrowse link 1 58,795,233 58,847,503 RGD:6480464
G Ccl11 chemokine (C-C motif) ligand 11 JBrowse link 11 82,057,832 82,062,955 RGD:6480464
G Ccl2 chemokine (C-C motif) ligand 2 JBrowse link 11 82,035,577 82,037,452 RGD:6480464
G Ccl3 chemokine (C-C motif) ligand 3 JBrowse link 11 83,647,843 83,649,378 RGD:6480464
G Ccl4 chemokine (C-C motif) ligand 4 JBrowse link 11 83,648,624 83,664,683 RGD:6480464
G Ccl5 chemokine (C-C motif) ligand 5 JBrowse link 11 83,525,778 83,530,518 RGD:6480464
G Ccng1 cyclin G1 JBrowse link 11 40,748,552 40,755,309 RGD:6480464
G Cct5 chaperonin containing Tcp1, subunit 5 (epsilon) JBrowse link 15 31,590,800 31,601,846 RGD:6480464
G Cd200 CD200 antigen JBrowse link 16 45,382,111 45,409,060 RGD:6480464
G Cd40lg CD40 ligand JBrowse link X 57,212,143 57,224,042 RGD:6480464
G Cd44 CD44 antigen JBrowse link 2 102,811,141 102,901,669 RGD:6480464
G Cd55 CD55 molecule, decay accelerating factor for complement JBrowse link 1 130,429,798 130,465,009 RGD:6480464
G Cd69 CD69 antigen JBrowse link 6 129,267,324 129,275,375 RGD:6480464
G Cd86 CD86 antigen JBrowse link 16 36,568,956 36,666,158 RGD:6480464
G Cdh17 cadherin 17 JBrowse link 4 11,758,157 11,817,905 RGD:6480464
G Cdk5r1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) JBrowse link 11 80,477,023 80,481,184 RGD:6480464
G Cfl1 cofilin 1, non-muscle JBrowse link 19 5,490,455 5,494,031 RGD:6480464
G Cftr cystic fibrosis transmembrane conductance regulator JBrowse link 6 18,170,687 18,322,770 RGD:6480464
G Chuk conserved helix-loop-helix ubiquitous kinase JBrowse link 19 44,073,334 44,107,505 RGD:6480464
G Cln3 ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease) JBrowse link 7 126,571,207 126,585,817 RGD:6480464
G Col6a1 collagen, type VI, alpha 1 JBrowse link 10 76,708,792 76,726,044 RGD:6480464
G Comt catechol-O-methyltransferase JBrowse link 16 18,406,882 18,426,716 RGD:6480464
G Crem cAMP responsive element modulator JBrowse link 18 3,266,354 3,337,773 RGD:6480464
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) JBrowse link 11 54,247,270 54,249,899 RGD:6480464
G Csnk2a1 casein kinase 2, alpha 1 polypeptide JBrowse link 2 152,226,535 152,281,856 RGD:6480464
G Ctbp1 C-terminal binding protein 1 JBrowse link 5 33,247,723 33,275,004 RGD:6480464
G Cul5 cullin 5 JBrowse link 9 53,614,581 53,667,507 RGD:6480464
G Cxcl15 chemokine (C-X-C motif) ligand 15 JBrowse link 5 90,794,534 90,803,067 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 9 57,687,928 57,703,824 RGD:6480464
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 JBrowse link 14 118,937,932 118,981,702 RGD:6480464
G Dnmt1 DNA methyltransferase (cytosine-5) 1 JBrowse link 9 20,907,206 20,959,888 RGD:6480464
G Dpyd dihydropyrimidine dehydrogenase JBrowse link 3 118,562,109 119,432,924 RGD:6480464
G Drd3 dopamine receptor D3 JBrowse link 16 43,754,015 43,825,982 RGD:6480464
G Dusp4 dual specificity phosphatase 4 JBrowse link 8 34,807,610 34,819,894 RGD:6480464
G Egf epidermal growth factor JBrowse link 3 129,677,574 129,755,322 RGD:6480464
G Egr1 early growth response 1 JBrowse link 18 34,861,207 34,864,956 RGD:6480464
G Egr2 early growth response 2 JBrowse link 10 67,534,469 67,542,188 RGD:6480464
G Evi2a ecotropic viral integration site 2a JBrowse link 11 79,526,560 79,530,609 RGD:6480464
G Fasl Fas ligand (TNF superfamily, member 6) JBrowse link 1 161,780,691 161,788,495 RGD:6480464
G Fos FBJ osteosarcoma oncogene JBrowse link 12 85,473,890 85,477,274 RGD:6480464
G Fosl2 fos-like antigen 2 JBrowse link 5 32,136,472 32,157,840 RGD:6480464
G Foxp1 forkhead box P1 JBrowse link 6 98,925,342 99,522,746 RGD:6480464
G Fyb FYN binding protein JBrowse link 15 6,522,796 6,665,608 RGD:6480464
G Gata3 GATA binding protein 3 JBrowse link 2 9,857,078 9,887,953 RGD:6480464
G Gfra2 glial cell line derived neurotrophic factor family receptor alpha 2 JBrowse link 14 70,890,107 70,979,840 RGD:6480464
G Gh growth hormone JBrowse link 11 106,300,261 106,303,703 RGD:6480464
G Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) JBrowse link 6 135,713,221 136,173,615 RGD:6480464
G Gzmb granzyme B JBrowse link 14 56,258,836 56,262,334 RGD:6480464
G H2-Ea histocompatibility 2, class II antigen E alpha JBrowse link 17 34,341,959 34,347,547 RGD:6480464
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha JBrowse link 5 30,119,423 30,154,980 RGD:6480464
G Hars histidyl-tRNA synthetase JBrowse link 18 36,766,528 36,783,205 RGD:6480464
G Hck hemopoietic cell kinase JBrowse link 2 153,108,468 153,151,441 RGD:6480464
G Hexb hexosaminidase B JBrowse link 13 97,176,331 97,198,357 RGD:6480464
G Hif1a hypoxia inducible factor 1, alpha subunit JBrowse link 12 73,901,324 73,947,554 RGD:6480464
G Hk2 hexokinase 2 JBrowse link 6 82,725,025 82,774,454 RGD:6480464
G Hmgb1 high mobility group box 1 JBrowse link 5 149,046,702 149,053,057 RGD:6480464
G Hrh2 histamine receptor H2 JBrowse link 13 54,191,970 54,236,182 RGD:6480464
G Hspa5 heat shock protein 5 JBrowse link 2 34,772,090 34,776,529 RGD:6480464
G Hspa8 heat shock protein 8 JBrowse link 9 40,801,276 40,805,202 RGD:6480464
G Ifng interferon gamma JBrowse link 10 118,441,046 118,445,894 RGD:6480464
G Ifngr2 interferon gamma receptor 2 JBrowse link 16 91,547,059 91,564,007 RGD:6480464
G Il10 interleukin 10 JBrowse link 1 131,019,845 131,024,970 RGD:6480464
G Il13 interleukin 13 JBrowse link 11 53,631,323 53,634,702 RGD:6480464
G Il17a interleukin 17A JBrowse link 1 20,730,905 20,734,496 RGD:6480464
G Il1a interleukin 1 alpha JBrowse link 2 129,299,609 129,310,186 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 2 129,364,569 129,371,164 RGD:6480464
G Il1rn interleukin 1 receptor antagonist JBrowse link 2 24,336,860 24,351,491 RGD:6480464
G Il2 interleukin 2 JBrowse link 3 37,120,713 37,125,954 RGD:6480464
G Il21 interleukin 21 JBrowse link 3 37,222,759 37,232,636 RGD:6480464
G Il2ra interleukin 2 receptor, alpha chain JBrowse link 2 11,642,792 11,693,194 RGD:6480464
G Il2rb interleukin 2 receptor, beta chain JBrowse link 15 78,479,256 78,511,621 RGD:6480464
G Il3 interleukin 3 JBrowse link 11 54,265,085 54,267,279 RGD:6480464
G Il4 interleukin 4 JBrowse link 11 53,612,460 53,618,665 RGD:6480464
G Il5 interleukin 5 JBrowse link 11 53,720,794 53,725,103 RGD:6480464
G Il6 interleukin 6 JBrowse link 5 30,013,114 30,019,975 RGD:6480464
G Il9 interleukin 9 JBrowse link 13 56,479,277 56,482,257 RGD:6480464
G Irf4 interferon regulatory factor 4 JBrowse link 13 30,749,233 30,766,981 RGD:6480464
G Jun jun proto-oncogene JBrowse link 4 95,049,036 95,052,222 RGD:6480464
G Kcnn3 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 JBrowse link 3 89,520,164 89,672,494 RGD:6480464
G Kcnn4 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 JBrowse link 7 24,369,826 24,385,212 RGD:6480464
G Klf4 Kruppel-like factor 4 (gut) JBrowse link 4 55,527,137 55,532,475 RGD:6480464
G Klf6 Kruppel-like factor 6 JBrowse link 13 5,861,489 5,870,393 RGD:6480464
G Kpnb1 karyopherin (importin) beta 1 JBrowse link 11 97,159,710 97,187,892 RGD:6480464
G Kras Kirsten rat sarcoma viral oncogene homolog JBrowse link 6 145,216,699 145,250,420 RGD:6480464
G Lamp1 lysosomal-associated membrane protein 1 JBrowse link 8 13,159,161 13,175,338 RGD:6480464
G Lcp1 lymphocyte cytosolic protein 1 JBrowse link 14 75,131,105 75,230,842 RGD:6480464
G Ltbp4 latent transforming growth factor beta binding protein 4 JBrowse link 7 27,305,140 27,339,720 RGD:6480464
G Map2k1 mitogen-activated protein kinase kinase 1 JBrowse link 9 64,185,769 64,253,605 RGD:6480464
G Map2k2 mitogen-activated protein kinase kinase 2 JBrowse link 10 81,105,913 81,124,697 RGD:6480464
G Mapk1 mitogen-activated protein kinase 1 JBrowse link 16 16,983,382 17,047,453 RGD:6480464
G Mapk3 mitogen-activated protein kinase 3 JBrowse link 7 126,759,626 126,765,816 RGD:6480464
G Mapt microtubule-associated protein tau JBrowse link 11 104,229,409 104,332,090 RGD:6480464
G Myc myelocytomatosis oncogene JBrowse link 15 61,985,341 61,990,361 RGD:6480464
G Myl9 myosin, light polypeptide 9, regulatory JBrowse link 2 156,775,408 156,781,657 RGD:6480464
G Naa80 N(alpha)-acetyltransferase 80, NatH catalytic subunit JBrowse link 9 107,580,669 107,584,048 RGD:6480464
G Ncs1 neuronal calcium sensor 1 JBrowse link 2 31,245,708 31,295,989 RGD:6480464
G Nell1 NEL-like 1 JBrowse link 7 49,975,350 50,863,289 RGD:6480464
G Nfatc1 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 JBrowse link 18 80,606,205 80,713,071 RGD:6480464
G Nfatc2 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 JBrowse link 2 168,476,410 168,601,657 RGD:6480464
G Nfatc3 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 JBrowse link 8 106,058,818 106,130,537 RGD:6480464
G Nfatc4 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4 JBrowse link 14 55,824,795 55,833,943 RGD:6480464
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 JBrowse link 2 75,675,513 75,704,663 RGD:6480464
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha JBrowse link 12 55,489,409 55,492,647 RGD:6480464
G Nkg7 natural killer cell group 7 sequence JBrowse link 7 43,437,138 43,438,246 RGD:6480464
G Nmi N-myc (and STAT) interactor JBrowse link 2 51,948,498 51,973,489 RGD:6480464
G Notch3 notch 3 JBrowse link 17 32,120,820 32,166,896 RGD:6480464
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 JBrowse link 4 48,045,078 48,086,447 RGD:6480464
G Pdk1 pyruvate dehydrogenase kinase, isoenzyme 1 JBrowse link 2 71,873,215 71,903,858 RGD:6480464
G Plcb1 phospholipase C, beta 1 JBrowse link 2 134,786,164 135,475,258 RGD:6480464
G Pld2 phospholipase D2 JBrowse link 11 70,539,492 70,558,110 RGD:6480464
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 JBrowse link 18 66,458,604 66,465,558 RGD:6480464
G Pou2f1 POU domain, class 2, transcription factor 1 JBrowse link 1 165,865,150 166,002,749 RGD:6480464
G Pou2f2 POU domain, class 2, transcription factor 2 JBrowse link 7 25,087,350 25,180,797 RGD:6480464
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha JBrowse link 5 51,454,249 52,115,853 RGD:6480464
G Ppp2ca protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform JBrowse link 11 52,098,824 52,122,749 RGD:6480464
G Ppp2cb protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform JBrowse link 8 33,599,621 33,619,804 RGD:6480464
G Prf1 perforin 1 (pore forming protein) JBrowse link 10 61,297,751 61,304,684 RGD:6480464
G Prkcq protein kinase C, theta JBrowse link 2 11,171,905 11,301,226 RGD:6480464
G Psmb10 proteasome (prosome, macropain) subunit, beta type 10 JBrowse link 8 105,935,728 105,938,392 RGD:6480464
G Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) JBrowse link 17 34,198,195 34,201,454 RGD:6480464
G Ptk2b PTK2 protein tyrosine kinase 2 beta JBrowse link 14 66,153,257 66,281,100 RGD:6480464
G Rbpj recombination signal binding protein for immunoglobulin kappa J region JBrowse link 5 53,555,779 53,657,445 RGD:6480464
G Rcan1 regulator of calcineurin 1 JBrowse link 16 92,391,951 92,466,169 RGD:6480464
G Rel reticuloendotheliosis oncogene JBrowse link 11 23,736,847 23,770,969 RGD:6480464
G Rhog ras homolog family member G JBrowse link 7 102,239,123 102,250,118 RGD:6480464
G Rnaset2a ribonuclease T2A JBrowse link 17 8,128,580 8,148,246 RGD:6480464
G Sart1 squamous cell carcinoma antigen recognized by T cells 1 JBrowse link 19 5,377,523 5,388,703 RGD:6480464
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 JBrowse link 5 137,061,504 137,072,272 RGD:6480464
G Sf3b4 splicing factor 3b, subunit 4 JBrowse link 3 96,172,506 96,177,564 RGD:6480464
G Sftpb surfactant associated protein B JBrowse link 6 72,304,610 72,314,373 RGD:6480464
G Sftpc surfactant associated protein C JBrowse link 14 70,520,941 70,524,081 RGD:6480464
G Sirt1 sirtuin 1 JBrowse link 10 63,319,005 63,339,035 RGD:6480464
G Sla src-like adaptor JBrowse link 15 66,780,819 66,831,829 RGD:6480464
G Slc39a7 solute carrier family 39 (zinc transporter), member 7 JBrowse link 17 34,028,266 34,031,690 RGD:6480464
G Slc3a2 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 JBrowse link 19 8,706,882 8,723,369 RGD:6480464
G Sod2 superoxide dismutase 2, mitochondrial JBrowse link 17 13,007,839 13,018,119 RGD:6480464
G Srpr signal recognition particle receptor ('docking protein') JBrowse link 9 35,211,203 35,217,003 RGD:6480464
G Stim1 stromal interaction molecule 1 JBrowse link 7 102,261,514 102,437,319 RGD:6480464
G Syn1 synapsin I JBrowse link X 20,860,511 20,920,918 RGD:6480464
G Tbx21 T-box 21 JBrowse link 11 97,098,007 97,115,331 RGD:6480464
G Tfrc transferrin receptor JBrowse link 16 32,608,896 32,632,794 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 7 25,687,002 25,705,077 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 17 35,199,367 35,202,007 RGD:6480464
G Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b JBrowse link 4 145,212,368 145,246,870 RGD:6480464
G Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 JBrowse link 4 156,013,595 156,016,613 RGD:6480464
G Tnfsf9 tumor necrosis factor (ligand) superfamily, member 9 JBrowse link 17 57,105,287 57,107,758 RGD:6480464
G Tnpo1 transportin 1 JBrowse link 13 98,839,019 98,926,384 RGD:6480464
G Traf1 TNF receptor-associated factor 1 JBrowse link 2 34,941,750 34,961,812 RGD:6480464
G Trib2 tribbles pseudokinase 2 JBrowse link 12 15,791,725 15,816,962 RGD:6480464
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 JBrowse link 11 73,234,149 73,261,322 RGD:6480464
G Txnip thioredoxin interacting protein JBrowse link 3 96,557,957 96,561,857 RGD:6480464
G Tyrobp TYRO protein tyrosine kinase binding protein JBrowse link 7 30,413,782 30,417,582 RGD:6480464
G Vim vimentin JBrowse link 2 13,574,311 13,582,826 RGD:6480464
G Zeb1 zinc finger E-box binding homeobox 1 JBrowse link 18 5,591,327 5,775,468 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21025
    role 21006
      biological role 21004
        biochemical role 19965
          metabolite 19892
            ionomycin 170
Path 2
Term Annotations click to browse term
  CHEBI ontology 21025
    subatomic particle 21019
      composite particle 21019
        hadron 21019
          baryon 21019
            nucleon 21019
              atomic nucleus 21019
                atom 21019
                  main group element atom 20860
                    p-block element atom 20860
                      carbon group element atom 20601
                        carbon atom 20578
                          organic molecular entity 20578
                            organic group 19174
                              organic divalent group 19164
                                organodiyl group 19164
                                  carbonyl group 19134
                                    carbonyl compound 19134
                                      carboxylic acid 18814
                                        monocarboxylic acid 17998
                                          fatty acid 16412
                                            unsaturated fatty acid 906
                                              polyunsaturated fatty acid 659
                                                ionomycin 170
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.