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Accession:CHEBI:63954 term browser browse the term
Definition:A very long-chain fatty acid that is docosa-10,16-dienoic acid which is substituted by methyl groups at positions 4, 6, 8, 12, 14, 18 and 20, by hydroxy groups at positions 11, 19 and 21, and by a (2',5-dimethyloctahydro-2,2'-bifuran-5-yl)ethanol group at position 21. An ionophore produced by Streptomyces conglobatus, it is used in research to raise the intracellular level of Ca(2+) and as a research tool to understand Ca(2+) transport across biological membranes.
Synonyms:exact_synonym: (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-trihydroxy-22-{(2S,2'R,5S,5'S)-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyloctahydro-2,2'-bifuran-5-yl}-4,6,8,12,14,18,20-heptamethyl-9-oxodocosa-10,16-dienoic acid
 related_synonym: Formula=C41H72O9;   InChI=1S/C41H72O9/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47)/b13-11+,34-24-/t25-,26-,27+,28-,29-,30+,31+,32-,33+,36+,37-,39-,40+,41+/m1/s1;   InChIKey=PGHMRUGBZOYCAA-ADZNBVRBSA-N;   SMILES=[H][C@]1(CC[C@](C)(O1)[C@@]1([H])CC[C@](C)(O1)[C@@H](C)O)C[C@H](O)[C@H](C)[C@H](O)[C@H](C)\\C=C\\C[C@@H](C)C[C@@H](C)C(\\O)=C\\C(=O)[C@@H](C)C[C@@H](C)C[C@H](C)CCC(O)=O
 xref: CAS:56092-81-0 "ChemIDplus"
 xref_mesh: MESH:D015759
 xref: PMID:19079959 "Europe PMC";   PMID:19496091 "Europe PMC";   Patent:US3873693;   Reaxys:3642126 "Reaxys"

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ionomycin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CXCL8 C-X-C motif chemokine ligand 8 JBrowse link 8 69,932,646 69,935,861 RGD:6480464

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Path 1
Term Annotations click to browse term
  CHEBI ontology 835
    role 812
      biological role 812
        biochemical role 685
          metabolite 669
            ionomycin 1
Path 2
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  CHEBI ontology 835
    subatomic particle 819
      composite particle 819
        hadron 819
          baryon 819
            nucleon 819
              atomic nucleus 819
                atom 819
                  main group element atom 807
                    p-block element atom 804
                      carbon group element atom 775
                        carbon atom 771
                          organic molecular entity 771
                            organic group 358
                              organic divalent group 356
                                organodiyl group 356
                                  carbonyl group 355
                                    carbonyl compound 355
                                      carboxylic acid 242
                                        monocarboxylic acid 131
                                          fatty acid 77
                                            unsaturated fatty acid 9
                                              polyunsaturated fatty acid 9
                                                ionomycin 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.