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ONTOLOGY REPORT - ANNOTATIONS


Term:7-chlorokynurenic acid
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Accession:CHEBI:63965 term browser browse the term
Definition:A quinolinemonocarboxylic acid that is quinaldic acid which is substituted by a hydroxy group at position 4 and by a chlorine at position 7. It is a potent NMDA glutamate receptor antagonist which antagonizes the strychnine-insensitive glycine site of the NMDA receptor. It also prevents neurodegeneration produced by quinolinic acid.
Synonyms:exact_synonym: 7-chloro-4-hydroxyquinoline-2-carboxylic acid
 related_synonym: 7-CKA;   7-Cl-KYNA;   7-chloro-4-hydroxy-2-carboxyquinoline;   Formula=C10H6ClNO3;   InChI=1S/C10H6ClNO3/c11-5-1-2-6-7(3-5)12-8(10(14)15)4-9(6)13/h1-4H,(H,12,13)(H,14,15);   InChIKey=UAWVRVFHMOSAPU-UHFFFAOYSA-N;   SMILES=OC(=O)c1cc(O)c2ccc(Cl)cc2n1
 xref: CAS:18000-24-3 "ChemIDplus";   LINCS:LSM-24944
 xref_mesh: MESH:C057013
 xref: PMID:11224142 "Europe PMC";   Reaxys:185645 "Reaxys"


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7-chlorokynurenic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Camk2a calcium/calmodulin-dependent protein kinase II alpha JBrowse link 18 56,193,978 56,295,869 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19745
    role 19692
      biological role 19690
        pharmacological role 18798
          antagonist 16196
            excitatory amino acid antagonist 10078
              NMDA receptor antagonist 8592
                7-chlorokynurenic acid 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19745
    subatomic particle 19741
      composite particle 19741
        hadron 19741
          baryon 19741
            nucleon 19741
              atomic nucleus 19741
                atom 19741
                  main group element atom 19625
                    p-block element atom 19625
                      carbon group element atom 19519
                        carbon atom 19513
                          organic molecular entity 19513
                            organic group 18424
                              organic divalent group 18416
                                organodiyl group 18416
                                  carbonyl group 18304
                                    carbonyl compound 18304
                                      carboxylic acid 17970
                                        aromatic carboxylic acid 10738
                                          quinolinemonocarboxylic acid 89
                                            7-chlorokynurenic acid 1
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