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ONTOLOGY REPORT - ANNOTATIONS


Term:leflunomide
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Accession:CHEBI:6402 term browser browse the term
Definition:A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Synonyms:exact_synonym: 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
 related_synonym: 5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamide;   5-Methylisoxazole-4-carboxylic acid (4-trifluoromethyl)anilide;   Arava;   Formula=C12H9F3N2O2;   InChI=1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18);   InChIKey=VHOGYURTWQBHIL-UHFFFAOYSA-N;   SMILES=Cc1oncc1C(=O)Nc1ccc(cc1)C(F)(F)F;   alpha,alpha,alpha-Trifluoro-5-methyl-4-isoxazolecarboxy-p-toluidide;   leflunomida;   leflunomidum
 xref: Beilstein:4323174 "Beilstein";   CAS:75706-12-6 "ChemIDplus";   CAS:75706-12-6 "KEGG COMPOUND";   DrugBank:DB01097;   Drug_Central:1552 "DrugCentral";   HMDB:HMDB0015229;   KEGG:C07905;   KEGG:D00749;   LINCS:LSM-3771
 xref_mesh: MESH:C045463
 xref: PMID:10515382 "Europe PMC";   PMID:10702725 "Europe PMC";   PMID:10890256 "Europe PMC";   PMID:11043056 "Europe PMC";   PMID:11053058 "Europe PMC";   PMID:11067959 "Europe PMC";   PMID:11271257 "Europe PMC";   PMID:11333342 "Europe PMC";   PMID:11340750 "Europe PMC";   PMID:11391470 "Europe PMC";   PMID:11475244 "Europe PMC";   PMID:11522581 "Europe PMC";   PMID:11707749 "Europe PMC";   PMID:11718154 "Europe PMC";   PMID:11876141 "Europe PMC";   PMID:11884931 "Europe PMC";   PMID:11994686 "Europe PMC";   PMID:12017890 "Europe PMC";   PMID:12074690 "Europe PMC";   PMID:12833393 "Europe PMC";   PMID:14622739 "Europe PMC";   PMID:15030575 "Europe PMC";   PMID:15127968 "Europe PMC";   PMID:15127974 "Europe PMC";   PMID:15188371 "Europe PMC";   PMID:15214907 "Europe PMC";   PMID:15385935 "Europe PMC";   PMID:15489872 "Europe PMC";   PMID:15537652 "Europe PMC";   PMID:15652966 "Europe PMC";   PMID:15665760 "Europe PMC";   PMID:15789891 "Europe PMC";   PMID:15899055 "Europe PMC";   PMID:15934905 "Europe PMC";   PMID:16106593 "Europe PMC";   PMID:16142756 "Europe PMC";   PMID:16202258 "Europe PMC";   PMID:16284916 "Europe PMC";   PMID:16638062 "Europe PMC";   PMID:16638420 "Europe PMC";   PMID:16645972 "Europe PMC";   PMID:16688677 "Europe PMC";   PMID:16769661 "Europe PMC";   PMID:16778342 "Europe PMC";   PMID:17366662 "Europe PMC";   PMID:17604599 "Europe PMC";   PMID:17646975 "Europe PMC";   PMID:17854740 "Europe PMC";   PMID:18034546 "Europe PMC";   PMID:18173611 "Europe PMC";   PMID:18413415 "Europe PMC";   PMID:18496682 "Europe PMC";   PMID:18663553 "Europe PMC";   PMID:18688040 "Europe PMC";   PMID:19169882 "Europe PMC";   PMID:19190124 "Europe PMC";   PMID:19344337 "Europe PMC";   PMID:19581389 "Europe PMC";   PMID:19715969 "Europe PMC";   PMID:19751817 "Europe PMC";   PMID:19770782 "Europe PMC";   PMID:7496341 "Europe PMC";   PMID:7676489 "Europe PMC";   PMID:8610393 "Europe PMC";   PMID:9075844 "Europe PMC";   PMID:9123314 "Europe PMC";   PMID:9625011 "Europe PMC";   PMID:9777697 "Europe PMC";   Patent:DE2854439;   Patent:US4284786;   Reaxys:4323174 "Reaxys";   Wikipedia:Leflunomide


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  CHEBI ontology 19749
    role 19696
      biological role 19694
        immunomodulator 13676
          immunosuppressive agent 11923
            leflunomide 2608
Path 2
Term Annotations click to browse term
  CHEBI ontology 19749
    subatomic particle 19745
      composite particle 19745
        hadron 19745
          baryon 19745
            nucleon 19745
              atomic nucleus 19745
                atom 19745
                  main group element atom 19630
                    p-block element atom 19630
                      carbon group element atom 19523
                        carbon atom 19517
                          organic molecular entity 19517
                            organic group 18427
                              organic divalent group 18418
                                organodiyl group 18418
                                  carbonyl group 18305
                                    carbonyl compound 18305
                                      carboxylic acid 17972
                                        carboacyl group 17080
                                          univalent carboacyl group 17080
                                            carbamoyl group 16809
                                              carboxamide 16809
                                                monocarboxylic acid amide 14167
                                                  leflunomide 2608
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