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ONTOLOGY REPORT - ANNOTATIONS


Term:leflunomide
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Accession:CHEBI:6402 term browser browse the term
Definition:A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Synonyms:exact_synonym: 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
 related_synonym: 5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamide;   5-Methylisoxazole-4-carboxylic acid (4-trifluoromethyl)anilide;   Arava;   Formula=C12H9F3N2O2;   InChI=1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18);   InChIKey=VHOGYURTWQBHIL-UHFFFAOYSA-N;   SMILES=Cc1oncc1C(=O)Nc1ccc(cc1)C(F)(F)F;   alpha,alpha,alpha-Trifluoro-5-methyl-4-isoxazolecarboxy-p-toluidide;   leflunomida;   leflunomidum
 xref: Beilstein:4323174 "Beilstein";   CAS:75706-12-6 "ChemIDplus";   CAS:75706-12-6 "KEGG COMPOUND";   DrugBank:DB01097;   Drug_Central:1552 "DrugCentral";   HMDB:HMDB0015229;   KEGG:C07905;   KEGG:D00749;   LINCS:LSM-3771
 xref_mesh: MESH:C045463
 xref: PMID:10515382 "Europe PMC";   PMID:10702725 "Europe PMC";   PMID:10890256 "Europe PMC";   PMID:11043056 "Europe PMC";   PMID:11053058 "Europe PMC";   PMID:11067959 "Europe PMC";   PMID:11271257 "Europe PMC";   PMID:11333342 "Europe PMC";   PMID:11340750 "Europe PMC";   PMID:11391470 "Europe PMC";   PMID:11475244 "Europe PMC";   PMID:11522581 "Europe PMC";   PMID:11707749 "Europe PMC";   PMID:11718154 "Europe PMC";   PMID:11876141 "Europe PMC";   PMID:11884931 "Europe PMC";   PMID:11994686 "Europe PMC";   PMID:12017890 "Europe PMC";   PMID:12074690 "Europe PMC";   PMID:12833393 "Europe PMC";   PMID:14622739 "Europe PMC";   PMID:15030575 "Europe PMC";   PMID:15127968 "Europe PMC";   PMID:15127974 "Europe PMC";   PMID:15188371 "Europe PMC";   PMID:15214907 "Europe PMC";   PMID:15385935 "Europe PMC";   PMID:15489872 "Europe PMC";   PMID:15537652 "Europe PMC";   PMID:15652966 "Europe PMC";   PMID:15665760 "Europe PMC";   PMID:15789891 "Europe PMC";   PMID:15899055 "Europe PMC";   PMID:15934905 "Europe PMC";   PMID:16106593 "Europe PMC";   PMID:16142756 "Europe PMC";   PMID:16202258 "Europe PMC";   PMID:16284916 "Europe PMC";   PMID:16638062 "Europe PMC";   PMID:16638420 "Europe PMC";   PMID:16645972 "Europe PMC";   PMID:16688677 "Europe PMC";   PMID:16769661 "Europe PMC";   PMID:16778342 "Europe PMC";   PMID:17366662 "Europe PMC";   PMID:17604599 "Europe PMC";   PMID:17646975 "Europe PMC";   PMID:17854740 "Europe PMC";   PMID:18034546 "Europe PMC";   PMID:18173611 "Europe PMC";   PMID:18413415 "Europe PMC";   PMID:18496682 "Europe PMC";   PMID:18663553 "Europe PMC";   PMID:18688040 "Europe PMC";   PMID:19169882 "Europe PMC";   PMID:19190124 "Europe PMC";   PMID:19344337 "Europe PMC";   PMID:19581389 "Europe PMC";   PMID:19715969 "Europe PMC";   PMID:19751817 "Europe PMC";   PMID:19770782 "Europe PMC";   PMID:7496341 "Europe PMC";   PMID:7676489 "Europe PMC";   PMID:8610393 "Europe PMC";   PMID:9075844 "Europe PMC";   PMID:9123314 "Europe PMC";   PMID:9625011 "Europe PMC";   PMID:9777697 "Europe PMC";   Patent:DE2854439;   Patent:US4284786;   Reaxys:4323174 "Reaxys";   Wikipedia:Leflunomide


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  CHEBI ontology 19596
    role 19539
      biological role 19537
        immunomodulator 12646
          immunosuppressive agent 11913
            leflunomide 2605
Path 2
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  CHEBI ontology 19596
    subatomic particle 19592
      composite particle 19592
        hadron 19592
          baryon 19592
            nucleon 19592
              atomic nucleus 19592
                atom 19592
                  main group element atom 19471
                    p-block element atom 19471
                      carbon group element atom 19345
                        carbon atom 19337
                          organic molecular entity 19337
                            organic group 18299
                              organic divalent group 18289
                                organodiyl group 18289
                                  carbonyl group 18176
                                    carbonyl compound 18176
                                      carboxylic acid 17840
                                        carboacyl group 16924
                                          univalent carboacyl group 16924
                                            carbamoyl group 16602
                                              carboxamide 16602
                                                monocarboxylic acid amide 13169
                                                  leflunomide 2605
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