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ONTOLOGY REPORT - ANNOTATIONS


Term:N-desmethylclozapine
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Accession:CHEBI:64050 term browser browse the term
Definition:A dibenzodoazepine substituted with chloro and piperazino groups which is a major metabolite of clozapine; a potent and selective 5-HT2C serotonin receptor antagonist.
Synonyms:exact_synonym: 8-chloro-11-(piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
 related_synonym: 8-Chloro-11-(1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine;   Demethylclozapine;   Desmethylclozapine;   Formula=C17H17ClN4;   InChI=1S/C17H17ClN4/c18-12-5-6-15-16(11-12)21-17(22-9-7-19-8-10-22)13-3-1-2-4-14(13)20-15/h1-6,11,19-20H,7-10H2;   InChIKey=JNNOSTQEZICQQP-UHFFFAOYSA-N;   N-desmethyl clozapine;   NDMC;   Norclozapine;   SMILES=Clc1ccc2Nc3ccccc3C(=Nc2c1)N1CCNCC1
 xref: CAS:6104-71-8 "ChemIDplus"
 xref_mesh: MESH:C058272
 xref: PMID:20156258 "Europe PMC";   PMID:20463634 "Europe PMC";   PMID:21134422 "Europe PMC";   PMID:21658379 "Europe PMC";   PMID:21712711 "Europe PMC";   PMID:21726287 "Europe PMC";   PMID:21835172 "Europe PMC";   PMID:21855612 "Europe PMC";   PMID:21912901 "Europe PMC";   PMID:21917240 "Europe PMC";   Reaxys:762289 "Reaxys";   Wikipedia:Desmethylclozapine


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N-desmethylclozapine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6480464
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 JBrowse link 6 2,308,179 2,316,739 RGD:6480464
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 JBrowse link 1 147,713,879 147,814,410 RGD:6480464
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 JBrowse link 1 147,236,480 147,307,988 RGD:6480464
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 JBrowse link 7 123,599,264 123,608,436 RGD:6480464
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 JBrowse link 5 119,546,458 119,564,843 RGD:6480464
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 JBrowse link 12 19,074,288 19,114,491 RGD:6480464
G Htr2a 5-hydroxytryptamine receptor 2A JBrowse link 15 56,666,152 56,732,469 RGD:6480464

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19728
    role 19675
      biological role 19673
        biochemical role 19178
          metabolite 19150
            N-desmethylclozapine 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    p-block element atom 19610
                      carbon group element atom 19501
                        carbon atom 19494
                          organic molecular entity 19494
                            organic molecule 19417
                              organic cyclic compound 19184
                                organic heterocyclic compound 18262
                                  organic heteropolycyclic compound 17570
                                    organic heterotricyclic compound 13728
                                      dibenzodiazepine 9
                                        N-desmethylclozapine 9
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.