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ONTOLOGY REPORT - ANNOTATIONS


Term:RS 39604
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Accession:CHEBI:64083 term browser browse the term
Definition:An aromatic ether that is the 3,5-dimethoxybenzyl derivative of N-(2-{4-[3-(4-amino-5-chloro-2-hydroxyphenyl)-3-oxopropyl]piperidin-1-yl}ethyl)methanesulfonamide. A potent and selective 5-HT4 antagonist, with a pKi of 9.1 at 5-HT4 receptors in guinea pig striatal membranes and greater than 1000-fold selectivity over 5-HT1A, 2C, 3 and D1, D2, M1, M2, AT1, B1 and alpha1C receptors. The ketone group gives RS 39604 a relatively long half life; it is also orally active and so suitable for in vivo studies.
Synonyms:related_synonym: Formula=C26H36ClN3O6S;   InChI=1S/C26H36ClN3O6S/c1-34-20-12-19(13-21(14-20)35-2)17-36-26-16-24(28)23(27)15-22(26)25(31)5-4-18-6-9-30(10-7-18)11-8-29-37(3,32)33/h12-16,18,29H,4-11,17,28H2,1-3H3;   InChIKey=BKVIWGRFRKLFIO-UHFFFAOYSA-N;   RS-67506;   RS67506;   SMILES=COc1cc(COc2cc(N)c(Cl)cc2C(=O)CCC2CCN(CCNS(C)(=O)=O)CC2)cc(OC)c1
 xref: LINCS:LSM-2461
 xref_mesh: MESH:C475107
 xref: PMID:11739263 "Europe PMC";   PMID:12095647 "Europe PMC";   PMID:15272208 "Europe PMC";   PMID:21689105 "Europe PMC";   PMID:7582507 "Europe PMC";   PMID:8903510 "Europe PMC";   PMID:9243330 "Europe PMC";   PMID:9689461 "Europe PMC";   Reaxys:8524141 "Reaxys"


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RS 39604 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Htr4 5-hydroxytryptamine receptor 4 JBrowse link 18 57,637,013 57,820,317 RGD:6480464

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  CHEBI ontology 19728
    role 19675
      biological role 19673
        pharmacological role 18793
          neurotransmitter agent 16396
            serotonergic drug 3917
              serotonergic antagonist 2224
                RS 39604 1
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  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    p-block element atom 19610
                      chalcogen 19322
                        oxygen atom 19283
                          oxygen molecular entity 19283
                            hydroxides 19042
                              oxoacid 18106
                                chalcogen oxoacid 11403
                                  sulfur oxoacid 10994
                                    sulfonic acid 7253
                                      sulfonic acid derivative 7253
                                        sulfonamide 3125
                                          RS 39604 1
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