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ONTOLOGY REPORT - ANNOTATIONS


Term:vanoxerine dihydrochloride
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Accession:CHEBI:64086 term browser browse the term
Definition:A hydrochloride salt that is obtained by reaction of vanoxerine with two equivalents of hydrogen chloride. Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration.
Synonyms:exact_synonym: 1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine dihydrochloride
 related_synonym: 1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazinediium dichloride;   Formula=C28H34Cl2F2N2O;   GBR 12909 dihydrochloride;   GBR12909 dihydrochloride;   InChI=1S/C28H32F2N2O.2ClH/c29-26-12-8-24(9-13-26)28(25-10-14-27(30)15-11-25)33-22-21-32-19-17-31(18-20-32)16-4-7-23-5-2-1-3-6-23;;/h1-3,5-6,8-15,28H,4,7,16-22H2;2*1H;   InChIKey=MIBSKSYCRFWIRU-UHFFFAOYSA-N;   SMILES=Cl.Cl.Fc1ccc(cc1)C(OCCN1CCN(CCCc2ccccc2)CC1)c1ccc(F)cc1;   Vanoxerine hydrochloride
 xref: CAS:67469-78-7 "ChemIDplus"
 xref_mesh: MESH:C043425
 xref: PMID:10640288 "Europe PMC";   PMID:10939577 "Europe PMC";   PMID:16014753 "Europe PMC";   PMID:7700571 "Europe PMC";   PMID:8884229 "Europe PMC";   Reaxys:5696321 "Reaxys"


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vanoxerine dihydrochloride term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 JBrowse link 1 147,713,879 147,814,410 RGD:6480464
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 JBrowse link 1 147,236,480 147,307,988 RGD:6480464
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 JBrowse link 1 213,511,892 213,522,195 RGD:6480464
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6480464
G Gdnf glial cell derived neurotrophic factor JBrowse link 2 56,884,181 56,912,964 RGD:6480464
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:6480464
G Pdyn prodynorphin JBrowse link 3 122,194,327 122,206,671 RGD:6480464
G Slc18a2 solute carrier family 18 member A2 JBrowse link 1 280,397,831 280,457,968 RGD:6480464
G Slc6a3 solute carrier family 6 member 3 JBrowse link 1 32,323,011 32,363,983 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19764
    role 19711
      biological role 19710
        pharmacological role 18809
          neurotransmitter agent 16413
            dopaminergic agent 5045
              dopamine uptake inhibitor 4521
                vanoxerine dihydrochloride 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19764
    subatomic particle 19762
      composite particle 19762
        hadron 19762
          baryon 19762
            nucleon 19762
              atomic nucleus 19762
                atom 19762
                  main group element atom 19646
                    p-block element atom 19646
                      halogen 17899
                        chlorine atom 17661
                          chlorine molecular entity 17661
                            elemental chlorine 8376
                              monoatomic chlorine 8357
                                chloride 8357
                                  chloride salt 8357
                                    organic chloride salt 654
                                      hydrochloride 427
                                        vanoxerine dihydrochloride 10
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.