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Term:4-fluoro-N-\{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl\}benzamide hydrochloride
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Accession:CHEBI:64099 term browser browse the term
Definition:A hydrochloride salt that is obtained by reaction of 4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide with one equivalent of hydrogen chloride. Highly potent selective 5-HT1A receptor full agonist (pKi values are 9.0, 6.6, 7.5, 6.6 and < 6.0 for 5-HT1A, 5-HT1B, 5-HT1C, 5-HT2 and 5-HT3 receptors respectively). Possibly binds between the agonist binding site and the G protein interaction switch site, affecting the activation mechanism, and may display positive cooperativity. Anxiolytic following central administration in vivo.
Synonyms:related_synonym: 1-((4-Fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride;   Formula=C24H27ClFN3O2;   InChI=1S/C24H26FN3O2.ClH/c1-30-21-10-7-18-3-2-4-23(22(18)17-21)28-15-13-27(14-16-28)12-11-26-24(29)19-5-8-20(25)9-6-19;/h2-10,17H,11-16H2,1H3,(H,26,29);1H;   InChIKey=HWLZKPKZVOLFGK-UHFFFAOYSA-N;   S 14506;   S 14506 hydrochloride;   S 14506 monohydrochloride;   S14506 hydrochloride;   S14506 monohydrochloride;   SMILES=Cl.COc1ccc2cccc(N3CCN(CCNC(=O)c4ccc(F)cc4)CC3)c2c1
 xref: CAS:135721-98-1 "ChemIDplus"
 xref_mesh: MESH:C092824
 xref: PMID:7698199 "Europe PMC";   Reaxys:8374093 "Reaxys"

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4-fluoro-N-\{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl\}benzamide hydrochloride term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Htr1a 5-hydroxytryptamine receptor 1A JBrowse link 2 36,246,628 36,247,896 RGD:6480464

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  CHEBI ontology 19754
    role 19701
      biological role 19700
        pharmacological role 18807
          neurotransmitter agent 16417
            serotonergic drug 3936
              serotonergic agonist 980
                4-fluoro-N-\{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl\}benzamide hydrochloride 1
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Term Annotations click to browse term
  CHEBI ontology 19754
    subatomic particle 19752
      composite particle 19752
        hadron 19752
          baryon 19752
            nucleon 19752
              atomic nucleus 19752
                atom 19752
                  main group element atom 19637
                    p-block element atom 19637
                      halogen 17901
                        chlorine atom 17668
                          chlorine molecular entity 17668
                            elemental chlorine 8386
                              monoatomic chlorine 8367
                                chloride 8367
                                  chloride salt 8367
                                    organic chloride salt 655
                                      hydrochloride 427
                                        4-fluoro-N-\{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl\}benzamide hydrochloride 1
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