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ONTOLOGY REPORT - ANNOTATIONS


Term:imetit
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Accession:CHEBI:64156 term browser browse the term
Definition:An imidothiocarbamic ester that consists of isothiourea in which the thiol hydrogen is substituted by a 2-(imidazol-4-yl)ethyl group. An extremely potent, high affinity agonist at H3 and H4 receptors (Ki values are 0.3 and 2.7 nM respectively). Induces shape change in eosinophils with an EC50 of 25 nM. Centrally active following systemic administration.
Synonyms:exact_synonym: 2-(1H-imidazol-4-yl)ethyl carbamimidothioate
 related_synonym: Formula=C6H10N4S;   InChI=1S/C6H10N4S/c7-6(8)11-2-1-5-3-9-4-10-5/h3-4H,1-2H2,(H3,7,8)(H,9,10);   InChIKey=PEHSVUKQDJULKE-UHFFFAOYSA-N;   S-(2-(4-Imidazolyl)ethyl)isothiourea;   SMILES=NC(=N)SCCc1c[nH]cn1
 xref: CAS:102203-18-9 "ChemIDplus";   CAS:102203-18-9 "KEGG COMPOUND";   KEGG:C17931
 xref_mesh: MESH:C077430
 xref: Reaxys:880781 "Reaxys";   Wikipedia:Imetit
 cyclic_relationship: is_conjugate_base_of CHEBI:64157


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imetit term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hrh3 histamine receptor H3 JBrowse link 3 175,474,310 175,479,395 RGD:6480464
G Hrh4 histamine receptor H4 JBrowse link 18 4,365,429 4,382,599 RGD:6480464
G Ntf3 neurotrophin 3 JBrowse link 4 158,636,883 158,705,886 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19728
    chemical entity 19726
      atom 19724
        nonmetal atom 19597
          sulfur atom 16127
            sulfur molecular entity 16127
              organosulfur compound 15019
                imidothiocarbamic ester 70
                  imetit 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    p-block element atom 19610
                      carbon group element atom 19501
                        carbon atom 19494
                          organic molecular entity 19494
                            organic molecule 19417
                              organic cyclic compound 19184
                                organic heterocyclic compound 18262
                                  heteroarene 15814
                                    monocyclic heteroarene 13126
                                      azole 12255
                                        diazole 8078
                                          imidazoles 7631
                                            imetit 3
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.