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ONTOLOGY REPORT - ANNOTATIONS


Term:nafadotride
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Accession:CHEBI:64191 term browser browse the term
Definition:A naphthalenecarboxamide resulting from the formal condensation of the carboxylic acid group of 4-cyano-1-methoxynaphthalene-2-carboxylic acid with the primary amino group of 1-(1-butylpyrrolidin-2-yl]methanamine. It is a highly potent, competitive, preferential dopamine D3 receptor antagonist, centrally active upon systemic administration.
Synonyms:exact_synonym: N-[(1-butylpyrrolidin-2-yl)methyl]-4-cyano-1-methoxynaphthalene-2-carboxamide
 related_synonym: Formula=C22H27N3O2;   InChI=1S/C22H27N3O2/c1-3-4-11-25-12-7-8-17(25)15-24-22(26)20-13-16(14-23)18-9-5-6-10-19(18)21(20)27-2/h5-6,9-10,13,17H,3-4,7-8,11-12,15H2,1-2H3,(H,24,26);   InChIKey=IDZASIQMRGPBCQ-UHFFFAOYSA-N;   SMILES=CCCCN1CCCC1CNC(=O)c1cc(C#N)c2ccccc2c1OC
 xref: CAS:149649-22-9 "ChemIDplus";   LINCS:LSM-1755
 xref_mesh: MESH:C097285
 xref: PMID:8531087 "Europe PMC";   PMID:9252981 "Europe PMC";   Reaxys:8356954 "Reaxys";   Wikipedia:Nafadotride


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nafadotride term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Drd2 dopamine receptor D2 JBrowse link 8 53,678,777 53,743,643 RGD:6480464
G Drd3 dopamine receptor D3 JBrowse link 11 61,819,102 61,883,223 RGD:6480464
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19728
    chemical entity 19726
      group 19641
        pseudohalo group 2772
          cyano group 2772
            nitrile 2772
              nafadotride 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    p-block element atom 19610
                      carbon group element atom 19501
                        carbon atom 19494
                          organic molecular entity 19494
                            organic group 18413
                              organic divalent group 18404
                                organodiyl group 18404
                                  carbonyl group 18293
                                    carbonyl compound 18293
                                      carboxylic acid 17960
                                        carboacyl group 17072
                                          univalent carboacyl group 17072
                                            carbamoyl group 16801
                                              carboxamide 16801
                                                monocarboxylic acid amide 14163
                                                  arenecarboxamide 6485
                                                    naphthalenecarboxamide 3
                                                      nafadotride 3
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.