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Accession:CHEBI:64203 term browser browse the term
Definition:A dibenzothiepine that is 10,11-dihydrodibenzo[b,f]thiepine bearing additional methylthio and 4-methylpiperazin-1-yl substituents at positions 8 and 10 respectively. Potent 5-HT2 antagonist, also active as 5-HT1 antagonist. Differentiates 5-HT1D sub-types. Also displays affinity for rodent 5-HT5B, 5-HT5A, 5-HT7 and 5-HT6 receptors (pK1 values are 6.6, 7.0, 8.4 and 8.7 respectively).
Synonyms:exact_synonym: 1-methyl-4-[8-(methylsulfanyl)-10,11-dihydrodibenzo[b,f]thiepin-10-yl]piperazine
 related_synonym: (+-)-10-(4-Methylpiperazinyl)-8-(methylthio)-10,11-dihydrodibenzo(b,f)thiepin;   (+-)-8-Methylthio-10-(4-methylpiperazino)-10,11-dihydrodibenzo(b,f)thiepin;   1-(10,11-Dihydro-8-(methylthio)dibenzo(b,f)thiepin-10-yl)-4-methylpiperazine;   1-methyl-4-[8-(methylthio)-10,11-dihydrodibenzo[b,f]thiepin-10-yl]piperazine;   Formula=C20H24N2S2;   InChI=1S/C20H24N2S2/c1-21-9-11-22(12-10-21)18-13-15-5-3-4-6-19(15)24-20-8-7-16(23-2)14-17(18)20/h3-8,14,18H,9-13H2,1-2H3;   InChIKey=RLJFTICUTYVZDG-UHFFFAOYSA-N;   Methiothepine;   SMILES=CSc1ccc2Sc3ccccc3CC(N3CCN(C)CC3)c2c1;   metitepina;   metitepine;   metitepinum
 xref: CAS:20229-30-5 "ChemIDplus";   LINCS:LSM-4320
 xref_mesh: MESH:D008719
 xref: PMID:18996971 "Europe PMC";   PMID:19837141 "Europe PMC";   PMID:19995401 "Europe PMC";   PMID:20171242 "Europe PMC";   PMID:20233210 "Europe PMC";   PMID:20331882 "Europe PMC";   PMID:20547148 "Europe PMC";   PMID:21062995 "Europe PMC";   PMID:21403818 "Europe PMC";   PMID:21514998 "Europe PMC";   PMID:21964383 "Europe PMC";   Patent:NL6608618;   Patent:US3379729;   Patent:US4444778;   Patent:US6331536;   Reaxys:626221 "Reaxys";   Wikipedia:Metitepine
 cyclic_relationship: is_conjugate_base_of CHEBI:64204

show annotations for term's descendants       view all columns           Sort by:
methiothepin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adra1a adrenoceptor alpha 1A JBrowse link 15 43,296,997 43,398,314 RGD:6480464
G Htr1a 5-hydroxytryptamine receptor 1A JBrowse link 2 36,246,628 36,247,896 RGD:6480464
G Htr1b 5-hydroxytryptamine receptor 1B JBrowse link 8 89,113,984 89,130,830 RGD:6480464
G Htr2a 5-hydroxytryptamine receptor 2A JBrowse link 15 56,666,152 56,732,469 RGD:6480464
G Htr7 5-hydroxytryptamine receptor 7 JBrowse link 1 254,547,964 254,671,811 RGD:6480464
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:6480464

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  CHEBI ontology 19716
    role 19663
      biological role 19661
        pharmacological role 18755
          neurotransmitter agent 16393
            serotonergic drug 3858
              serotonergic antagonist 2228
                methiothepin 6
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Term Annotations click to browse term
  CHEBI ontology 19716
    subatomic particle 19712
      composite particle 19712
        hadron 19712
          baryon 19712
            nucleon 19712
              atomic nucleus 19712
                atom 19712
                  main group element atom 19598
                    main group molecular entity 19598
                      s-block molecular entity 19361
                        hydrogen molecular entity 19350
                          hydrides 18280
                            inorganic hydride 17204
                              pnictogen hydride 17166
                                nitrogen hydride 17003
                                  azane 16693
                                    ammonia 16690
                                      organic amino compound 16689
                                        tertiary amino compound 8527
                                          N-alkylpiperazine 2959
                                            methiothepin 6
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.