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ONTOLOGY REPORT - ANNOTATIONS


Term:leupeptin
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Accession:CHEBI:6426 term browser browse the term
Definition:A tripeptide composed of N-acetylleucyl, leucyl and argininal residues joined in sequence.
Synonyms:exact_synonym: N-acetyl-L-leucyl-N-[(2S)-5-carbamimidamido-1-oxopentan-2-yl]-L-leucinamide
 related_synonym: Ac-L-Leu-L-Leu-L-Arg-H;   Ac-LLR-H;   Ac-Leu-Leu-Arg-H;   Formula=C20H38N6O4;   InChI=1S/C20H38N6O4/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23)/t15?,16-,17?/m0/s1;   InChIKey=GDBQQVLCIARPGH-ULQDDVLXSA-N;   N-acetyl-L-leucyl-L-leucyl-L-argininal;   N-acetyl-leucylleucylargininal;   SMILES=C([C@@H](NC([C@@H](NC([C@@H](NC(C)=O)CC(C)C)=O)CC(C)C)=O)CCCNC(=N)N)(=O)[H]
 xref: CAS:55123-66-5 "ChemIDplus";   KEGG:C01591
 xref_mesh: MESH:C032854
 xref: MetaCyc:LEUPEPTIN;   PMID:24393046 "Europe PMC";   PMID:26365578 "Europe PMC";   PMID:26399337 "Europe PMC";   Reaxys:2402463 "Reaxys";   Reaxys:24140639 "Reaxys";   Wikipedia:Leupeptin


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leupeptin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AKT1 AKT serine/threonine kinase 1 JBrowse link 14 104,769,349 104,795,748 RGD:6480464
G AQP8 aquaporin 8 JBrowse link 16 25,216,917 25,228,932 RGD:6480464
G BAX BCL2 associated X, apoptosis regulator JBrowse link 19 48,954,825 48,961,798 RGD:6480464
G CASP6 caspase 6 JBrowse link 4 109,688,628 109,703,445 RGD:6480464
G CDC25C cell division cycle 25C JBrowse link 5 138,285,265 138,338,355 RGD:6480464
G CDH1 cadherin 1 JBrowse link 16 68,737,292 68,835,537 RGD:6480464
G CIP2A cellular inhibitor of PP2A JBrowse link 3 108,545,752 108,589,456 RGD:6480464
G CTNNB1 catenin beta 1 JBrowse link 3 41,199,422 41,240,445 RGD:6480464
G CTSB cathepsin B JBrowse link 8 11,842,524 11,868,118 RGD:6480464
G CXCL8 C-X-C motif chemokine ligand 8 JBrowse link 4 73,740,569 73,743,716 RGD:6480464
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 JBrowse link 10 133,527,363 133,539,123 RGD:6480464
G EGF epidermal growth factor JBrowse link 4 109,912,883 110,013,766 RGD:6480464
G GJA1 gap junction protein alpha 1 JBrowse link 6 121,435,646 121,449,727 RGD:6480464
G IL1A interleukin 1 alpha JBrowse link 2 112,773,925 112,784,493 RGD:6480464
G IL6 interleukin 6 JBrowse link 7 22,725,889 22,732,002 RGD:6480464
G KLK8 kallikrein related peptidase 8 JBrowse link 19 50,996,008 51,001,702 RGD:6480464
G NEFL neurofilament light JBrowse link 8 24,950,955 24,956,612 RGD:6480464
G PLIN1 perilipin 1 JBrowse link 15 89,664,365 89,679,367 RGD:6480464
G TGFBR1 transforming growth factor beta receptor 1 JBrowse link 9 99,104,038 99,154,192 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 23805
    role 23692
      application 23078
        solvent 17840
          formic acid 8793
            formyl group 8760
              aldehyde 8760
                leupeptin 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 23805
    subatomic particle 23756
      composite particle 23756
        hadron 23756
          baryon 23756
            nucleon 23756
              atomic nucleus 23756
                atom 23756
                  main group element atom 23575
                    p-block element atom 23575
                      carbon group element atom 23289
                        carbon atom 23243
                          organic molecular entity 23243
                            organic group 21924
                              organic divalent group 21896
                                organodiyl group 21896
                                  carbonyl group 21868
                                    carbonyl compound 21868
                                      carboxylic acid 20917
                                        carboacyl group 19023
                                          univalent carboacyl group 19023
                                            carbamoyl group 18370
                                              carboxamide 18370
                                                peptide 9808
                                                  oligopeptide 1164
                                                    tripeptide 865
                                                      leupeptin 18
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.