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ONTOLOGY REPORT - ANNOTATIONS


Term:memantine
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Accession:CHEBI:64312 term browser browse the term
Definition:A primary aliphatic amine that is the 3,5-dimethyl derivative of 1-aminoadamantane. A low to moderate affinity uncompetitive (open-channel); NMDA receptor antagonist which binds preferentially to the NMDA receptor-operated cation channels.
Synonyms:exact_synonym: 3,5-dimethyladamantan-1-amine
 related_synonym: 1-Amino-3,5-dimethyladamantane;   3,5-Dimethyl-1-adamantanamine;   3,5-Dimethyl-1-aminoadamantane;   3,5-Dimethyltricyclo(3.3.1.1(3,7))decan-1-amine;   Formula=C12H21N;   InChI=1S/C12H21N/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10/h9H,3-8,13H2,1-2H3;   InChIKey=BUGYDGFZZOZRHP-UHFFFAOYSA-N;   SMILES=CC12CC3CC(C)(C1)CC(N)(C3)C2;   memantina;   memantinum
 alt_id: CHEBI:34832
 xref: CAS:19982-08-2;   DrugBank:DB01043;   Drug_Central:1679;   KEGG:C13736;   KEGG:D08174;   LINCS:LSM-5154
 xref_mesh: MESH:D008559
 xref: PMID:20104942;   PMID:21953515;   PMID:21955815;   PMID:22030128;   PMID:22134197;   PMID:22245025;   PMID:22248638;   PMID:22290557;   PMID:22297273;   PMID:22300835;   PMID:22311362;   PMID:22327556;   PMID:22329473;   PMID:22392787;   PMID:22414570;   PMID:22425751;   Patent:US2011282100;   Reaxys:2075983;   Wikipedia:Memantine
 cyclic_relationship: is_conjugate_base_of CHEBI:64325


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memantine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ache acetylcholinesterase JBrowse link 12 22,472,358 22,477,052 RGD:6480464
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:6480464
G Camk2a calcium/calmodulin-dependent protein kinase II alpha JBrowse link 18 56,193,978 56,295,869 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp7 caspase 7 JBrowse link 1 277,190,557 277,242,779 RGD:6480464
G Creb1 cAMP responsive element binding protein 1 JBrowse link 9 71,229,753 71,298,994 RGD:6480464
G Dlg4 discs large MAGUK scaffold protein 4 JBrowse link 10 56,625,845 56,655,543 RGD:6480464
G Dlgap2 DLG associated protein 2 JBrowse link 16 79,872,238 80,596,977 RGD:6480464
G Gfap glial fibrillary acidic protein JBrowse link 10 90,990,762 90,999,435 RGD:6480464
G Itgam integrin subunit alpha M JBrowse link 1 199,495,312 199,545,738 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Penk proenkephalin JBrowse link 5 17,056,412 17,061,762 RGD:6480464
G Prkcg protein kinase C, gamma JBrowse link 1 64,407,098 64,433,698 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19717
      biological role 19716
        pharmacological role 18801
          neurotransmitter agent 16429
            dopaminergic agent 5051
              memantine 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19655
                    main group molecular entity 19655
                      s-block molecular entity 19398
                        hydrogen molecular entity 19388
                          hydrides 18363
                            inorganic hydride 17213
                              pnictogen hydride 17176
                                nitrogen hydride 17011
                                  azane 16704
                                    ammonia 16703
                                      organic amino compound 16702
                                        primary amino compound 7836
                                          primary amine 5628
                                            primary aliphatic amine 136
                                              memantine 15
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.