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Accession:CHEBI:64318 term browser browse the term
Definition:A peptide ergot alkaloid that is dihydroergotamine in which a double bond replaces the single bond between positions 9 and 10.
Synonyms:exact_synonym: (5'alpha)-5'-benzyl-12'-hydroxy-2'-methyl-3',6',18-trioxoergotaman
 related_synonym: (5'alpha)-12'-hydroxy-2'-methyl-5'-(phenylmethyl)ergotoman-3',6',18-trione;   12'-hydroxy-2'-methyl-5'alpha-(phenylmethyl)ergotaman-3',6',18-trione;   Ergotamin;   Formula=C33H35N5O5;   Gynergen;   InChI=1S/C33H35N5O5/c1-32(35-29(39)21-15-23-22-10-6-11-24-28(22)20(17-34-24)16-25(23)36(2)18-21)31(41)38-26(14-19-8-4-3-5-9-19)30(40)37-13-7-12-27(37)33(38,42)43-32/h3-6,8-11,15,17,21,25-27,34,42H,7,12-14,16,18H2,1-2H3,(H,35,39)/t21-,25-,26+,27+,32-,33+/m1/s1;   InChIKey=XCGSFFUVFURLIX-VFGNJEKYSA-N;   SMILES=[H][C@@]12Cc3c[nH]c4cccc(C1=C[C@H](CN2C)C(=O)N[C@]1(C)O[C@]2(O)N([C@@H](Cc5ccccc5)C(=O)N5CCC[C@@]25[H])C1=O)c34;   ergotamina;   ergotaminum
 xref: Beilstein:78890 "ChemIDplus";   CAS:113-15-5 "ChemIDplus";   CAS:113-15-5 "KEGG DRUG";   CAS:113-15-5 "NIST Chemistry WebBook";   DrugBank:DB00696;   Drug_Central:1043 "DrugCentral";   KEGG:C07544;   KEGG:D07906
 xref_mesh: MESH:D004878
 xref: PMID:10560569 "Europe PMC";   PMID:10611116 "Europe PMC";   PMID:11386387 "Europe PMC";   PMID:12463275 "Europe PMC";   PMID:12525272 "Europe PMC";   PMID:12558771 "Europe PMC";   PMID:21181611 "Europe PMC";   PMID:21512122 "Europe PMC";   PMID:21878097 "Europe PMC";   PMID:21879189 "Europe PMC";   PMID:22347148 "Europe PMC";   PMID:22414189 "Europe PMC";   PMID:22417229 "Europe PMC";   PMID:22441761 "Europe PMC";   PMID:22444161 "Europe PMC";   PMID:22446707 "Europe PMC";   PMID:23243949 "Europe PMC";   PMID:24035295 "Europe PMC";   PMID:8825693 "Europe PMC";   PMID:9009470 "Europe PMC";   PMID:9032799 "Europe PMC";   Reaxys:78890 "Reaxys";   Wikipedia:Ergotamine

show annotations for term's descendants       view all columns           Sort by:
ergotamine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Calca calcitonin-related polypeptide alpha JBrowse link 1 184,184,018 184,188,922 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6480464
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:6480464
G Htr2b 5-hydroxytryptamine receptor 2B JBrowse link 9 93,112,781 93,130,135 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19728
    role 19675
      biological role 19673
        pharmacological role 18793
          analgesic 13046
            non-narcotic analgesic 11956
              ergotamine 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    p-block element atom 19610
                      carbon group element atom 19501
                        carbon atom 19494
                          organic molecular entity 19494
                            organic group 18413
                              cyclic organic group 1831
                                organic heterobicyclic ring 1831
                                  indole skeleton 1831
                                    indole alkaloid 1831
                                      terpenoid indole alkaloid 1462
                                        hemiterpenoid indole alkaloid 24
                                          ergot alkaloid 24
                                            peptide ergot alkaloid 5
                                              ergotamine 5
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.