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Accession:CHEBI:6432 term browser browse the term
Definition:A 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole that has S configuration. It is used (generally as the monohydrochloride salt) to treat parasitic worm infections in pigs, sheep and cattle and was formerly used in humans as an adjuvant to chemotherapy for the treatment of various cancers. It is also widely used as an adulterant to coccaine.
Synonyms:exact_synonym: (6S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole
 related_synonym: (-)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole;   (-)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole;   (-)-tetramisole;   (S)-(-)-levamisole;   (S)-(-)-tetramisole;   (S)-2,3,5,6-tetrahydro-6-phenylimidazo[2,1-b]thiazole;   Formula=C11H12N2S;   InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1;   InChIKey=HLFSDGLLUJUHTE-SNVBAGLBSA-N;   Ketrax;   Lepuron;   Levomysol;   Levovermax;   SMILES=C1CN2C[C@@H](N=C2S1)c1ccccc1;   Totalon;   Wormicid;   levamisol;   levamisolum
 xref: CAS:14769-73-4 "ChemIDplus";   CAS:14769-73-4 "KEGG COMPOUND";   DrugBank:DB00848;   Drug_Central:1561 "DrugCentral";   HMDB:HMDB0014986;   KEGG:C07070;   KEGG:D08114;   LINCS:LSM-6655
 xref_mesh: MESH:D007978
 xref: PMID:10701095 "Europe PMC";   PMID:12232676 "Europe PMC";   PMID:12749943 "Europe PMC";   PMID:15109274 "Europe PMC";   PMID:1618599 "Europe PMC";   PMID:17608969 "Europe PMC";   PMID:189006 "Europe PMC";   PMID:2050823 "Europe PMC";   PMID:22337783 "Europe PMC";   PMID:22607692 "Europe PMC";   PMID:23041983 "Europe PMC";   PMID:23152411 "Europe PMC";   PMID:23543977 "Europe PMC";   PMID:23577329 "Europe PMC";   PMID:23649929 "Europe PMC";   PMID:23921349 "Europe PMC";   PMID:24365689 "Europe PMC";   PMID:24440755 "Europe PMC";   PMID:365327 "Europe PMC";   PMID:366135 "Europe PMC";   PMID:366137 "Europe PMC";   PMID:669135 "Europe PMC";   PMID:6995092 "Europe PMC";   PMID:6995094 "Europe PMC";   PMID:7051554 "Europe PMC";   PMID:827785 "Europe PMC";   Patent:US3274209;   Patent:US3565907;   Patent:US3579530;   Reaxys:4233256 "Reaxys";   VSDB:1798;   Wikipedia:Levamisole
 cyclic_relationship: is_enantiomer_of CHEBI:77282

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levamisole term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alpl alkaline phosphatase, biomineralization associated JBrowse link 5 156,086,496 156,141,513 RGD:6480464
G Bak1 BCL2-antagonist/killer 1 JBrowse link 20 5,609,620 5,618,899 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Clu clusterin JBrowse link 15 42,626,612 42,665,858 RGD:6480464
G Dcc DCC netrin 1 receptor JBrowse link 18 66,518,213 67,629,801 RGD:6480464
G Edn1 endothelin 1 JBrowse link 17 22,136,814 22,143,745 RGD:6480464
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 JBrowse link 1 21,748,201 21,813,205 RGD:6480464
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6480464
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480464
G Il15 interleukin 15 JBrowse link 19 23,542,606 23,624,366 RGD:6480464
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:6480464
G Il23a interleukin 23 subunit alpha JBrowse link 7 2,710,609 2,712,723 RGD:6480464
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Nos3 nitric oxide synthase 3 JBrowse link 4 7,321,908 7,342,404 RGD:6480464
G Phex phosphate regulating endopeptidase homolog, X-linked JBrowse link X 40,460,047 40,717,982 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Rb1 RB transcriptional corepressor 1 JBrowse link 15 55,081,582 55,209,060 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19764
    role 19711
      biological role 19710
        immunomodulator 13673
          levamisole 21
            tetramisole 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19764
    subatomic particle 19762
      composite particle 19762
        hadron 19762
          baryon 19762
            nucleon 19762
              atomic nucleus 19762
                atom 19762
                  main group element atom 19646
                    p-block element atom 19646
                      carbon group element atom 19540
                        carbon atom 19529
                          organic molecular entity 19529
                            organic molecule 19447
                              organic cyclic compound 19207
                                organic heterocyclic compound 18277
                                  organic heteropolycyclic compound 17583
                                    organic heterobicyclic compound 16246
                                      imidazothiazole 92
                                        6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole 21
                                          levamisole 21
                                            tetramisole 0
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.