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Accession:CHEBI:64354 term browser browse the term
Definition:A quinazoline that consists of 1,2,3,4-tetrahydroquinazolin-4-one bearing additional methyl, 2-tolyl, sulfamyl and chloro substituents at positions 2, 3, 6 and 7 respectively. A quinazoline diuretic, with properties similar to thiazide diuretics.
Synonyms:exact_synonym: 7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide
 related_synonym: 2-Methyl-3-o-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone;   7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide;   7-Chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl-6-quinazolinesulfonamide;   Formula=C16H16ClN3O3S;   InChI=1S/C16H16ClN3O3S/c1-9-5-3-4-6-14(9)20-10(2)19-13-8-12(17)15(24(18,22)23)7-11(13)16(20)21/h3-8,10,19H,1-2H3,(H2,18,22,23);   InChIKey=AQCHWTWZEMGIFD-UHFFFAOYSA-N;   SMILES=CC1Nc2cc(Cl)c(cc2C(=O)N1c1ccccc1C)S(N)(=O)=O;   Zaroxolyn;   metolazona;   metolazonum
 alt_id: CHEBI:6903
 xref: CAS:17560-51-9 "ChemIDplus";   CAS:17560-51-9 "NIST Chemistry WebBook";   DrugBank:DB00524;   Drug_Central:1783 "DrugCentral";   KEGG:D00431;   LINCS:LSM-1680
 xref_mesh: MESH:D008788
 xref: PMID:12671341 "Europe PMC";   PMID:15095363 "Europe PMC";   PMID:1593359 "Europe PMC";   PMID:16189620 "Europe PMC";   PMID:16538931 "Europe PMC";   PMID:16717105 "Europe PMC";   PMID:16908225 "Europe PMC";   PMID:1886511 "Europe PMC";   PMID:1928234 "Europe PMC";   PMID:1946137 "Europe PMC";   PMID:2071258 "Europe PMC";   PMID:21387350 "Europe PMC";   PMID:21886902 "Europe PMC";   PMID:8199745 "Europe PMC";   PMID:8205244 "Europe PMC";   PMID:8870895 "Europe PMC";   PMID:9089428 "Europe PMC";   Patent:US2008139593;   Patent:US3360518;   Reaxys:965506 "Reaxys";   Wikipedia:Metolazone

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metolazone term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 JBrowse link 11 65,022,100 65,058,546 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19741
    role 19688
      application 19339
        pharmaceutical 19214
          drug 19214
            diuretic 1104
              metolazone 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19741
    subatomic particle 19737
      composite particle 19737
        hadron 19737
          baryon 19737
            nucleon 19737
              atomic nucleus 19737
                atom 19737
                  main group element atom 19622
                    p-block element atom 19622
                      chalcogen 19334
                        oxygen atom 19295
                          oxygen molecular entity 19295
                            hydroxides 19048
                              oxoacid 18111
                                chalcogen oxoacid 11399
                                  sulfur oxoacid 10990
                                    sulfonic acid 7241
                                      sulfonic acid derivative 7241
                                        sulfonamide 3120
                                          metolazone 1
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