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Accession:CHEBI:64354 term browser browse the term
Definition:A quinazoline that consists of 1,2,3,4-tetrahydroquinazolin-4-one bearing additional methyl, 2-tolyl, sulfamyl and chloro substituents at positions 2, 3, 6 and 7 respectively. A quinazoline diuretic, with properties similar to thiazide diuretics.
Synonyms:exact_synonym: 7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide
 related_synonym: 2-Methyl-3-o-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone;   7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide;   7-Chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl-6-quinazolinesulfonamide;   Formula=C16H16ClN3O3S;   InChI=1S/C16H16ClN3O3S/c1-9-5-3-4-6-14(9)20-10(2)19-13-8-12(17)15(24(18,22)23)7-11(13)16(20)21/h3-8,10,19H,1-2H3,(H2,18,22,23);   InChIKey=AQCHWTWZEMGIFD-UHFFFAOYSA-N;   SMILES=CC1Nc2cc(Cl)c(cc2C(=O)N1c1ccccc1C)S(N)(=O)=O;   Zaroxolyn;   metolazona;   metolazonum
 alt_id: CHEBI:6903
 xref: CAS:17560-51-9 "ChemIDplus";   CAS:17560-51-9 "NIST Chemistry WebBook";   DrugBank:DB00524;   Drug_Central:1783 "DrugCentral";   KEGG:D00431;   LINCS:LSM-1680
 xref_mesh: MESH:D008788
 xref: PMID:12671341 "Europe PMC";   PMID:15095363 "Europe PMC";   PMID:1593359 "Europe PMC";   PMID:16189620 "Europe PMC";   PMID:16538931 "Europe PMC";   PMID:16717105 "Europe PMC";   PMID:16908225 "Europe PMC";   PMID:1886511 "Europe PMC";   PMID:1928234 "Europe PMC";   PMID:1946137 "Europe PMC";   PMID:2071258 "Europe PMC";   PMID:21387350 "Europe PMC";   PMID:21886902 "Europe PMC";   PMID:8199745 "Europe PMC";   PMID:8205244 "Europe PMC";   PMID:8870895 "Europe PMC";   PMID:9089428 "Europe PMC";   Patent:US2008139593;   Patent:US3360518;   Reaxys:965506 "Reaxys";   Wikipedia:Metolazone

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metolazone term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 JBrowse link 11 65,022,100 65,058,546 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19748
    role 19695
      application 19350
        pharmaceutical 19224
          drug 19224
            diuretic 1106
              metolazone 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19748
    subatomic particle 19744
      composite particle 19744
        hadron 19744
          baryon 19744
            nucleon 19744
              atomic nucleus 19744
                atom 19744
                  main group element atom 19628
                    p-block element atom 19628
                      chalcogen 19337
                        oxygen atom 19298
                          oxygen molecular entity 19298
                            hydroxides 19053
                              oxoacid 18117
                                chalcogen oxoacid 11406
                                  sulfur oxoacid 10998
                                    sulfonic acid 7254
                                      sulfonic acid derivative 7254
                                        sulfonamide 3125
                                          metolazone 1
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