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ONTOLOGY REPORT - ANNOTATIONS


Term:levobunolol
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Accession:CHEBI:6438 term browser browse the term
Definition:A cyclic ketone that is 3,4-dihydronaphthalen-1-one substituted at position 5 by a 3-(tert-butylamino)-2-hydroxypropoxy group (the S-enantiomer). A non-selective beta-adrenergic antagonist used (as its hydrochloride salt) for treatment of glaucoma.
Synonyms:exact_synonym: 5-[(2S)-3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydronaphthalen-1(2H)-one
 related_synonym: (-)-Bunolol;   (S)-5-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)-3,4-dihydro-1(2H)-naphthalenone;   Formula=C17H25NO3;   InChI=1S/C17H25NO3/c1-17(2,3)18-10-12(19)11-21-16-9-5-6-13-14(16)7-4-8-15(13)20/h5-6,9,12,18-19H,4,7-8,10-11H2,1-3H3/t12-/m0/s1;   InChIKey=IXHBTMCLRNMKHZ-LBPRGKRZSA-N;   SMILES=CC(C)(C)NC[C@H](O)COc1cccc2C(=O)CCCc12;   levobunololum
 xref: Beilstein:6484587 "Beilstein";   CAS:47141-42-4 "ChemIDplus";   CAS:47141-42-4 "KEGG COMPOUND";   DrugBank:DB01210;   Drug_Central:431 "DrugCentral";   HMDB:HMDB0015341;   KEGG:C07914;   KEGG:D08115;   LINCS:LSM-6578
 xref_mesh: MESH:D002040
 xref: PMID:19626454 "Europe PMC";   PMID:20960417 "Europe PMC";   PMID:21368570 "Europe PMC";   PMID:23390358 "Europe PMC";   PMID:2873545 "Europe PMC";   PMID:2881799 "Europe PMC";   PMID:3019819 "Europe PMC";   PMID:3050679 "Europe PMC";   PMID:3058836 "Europe PMC";   PMID:3062528 "Europe PMC";   PMID:3067745 "Europe PMC";   PMID:3513594 "Europe PMC";   PMID:3881032 "Europe PMC";   PMID:3912600 "Europe PMC";   Patent:US2011263638;   Patent:US2011275617;   Patent:WO2008002929;   Patent:WO2011140194;   Reaxys:6484587 "Reaxys";   Wikipedia:Levobunolol
 cyclic_relationship: is_conjugate_acid_of CHEBI:72567


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levobunolol term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G RT1-DMb RT1 class II, locus DMb JBrowse link 20 3,945,383 3,952,838 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19728
    role 19675
      chemical role 19189
        environmental contaminant 18503
          naphthalene 2331
            tetralin 145
              levobunolol 1
                dihydrolevobunolol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    main group molecular entity 19610
                      s-block molecular entity 19378
                        hydrogen molecular entity 19367
                          hydrides 18278
                            organic hydride 17545
                              organic fundamental parent 17545
                                hydrocarbon 16957
                                  cyclic hydrocarbon 15096
                                    arene 15083
                                      polycyclic arene 14515
                                        ortho-fused polycyclic arene 9542
                                          ortho-fused bicyclic arene 2383
                                            naphthalene 2331
                                              tetralin 145
                                                levobunolol 1
                                                  dihydrolevobunolol 0
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