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ONTOLOGY REPORT - ANNOTATIONS


Term:somatostatin
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Accession:CHEBI:64628 term browser browse the term
Definition:A fourteen-membered heterodetic cyclic peptide comprising the sequence Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys cyclised by a disulfide bridge between the two Cys residues at positions 3 and 14.
Synonyms:exact_synonym: L-alanyl-N-[(4R,7S,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-19,34-bis(4-aminobutyl)-31-(2-amino-2-oxoethyl)-13,25,28-tribenzyl-4-carboxy-10,16-bis[(1R)-1-hydroxyethyl]-7-(hydroxymethyl)-22-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24,27,30,33,36-undecaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35-undecaazacyclooctatriacontan-37-yl]glycinamide
 related_synonym: Ala-Gly-cyclo-[Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys];   Formula=C76H104N18O19S2;   InChI=1S/C76H104N18O19S2/c1-41(79)64(100)82-37-61(99)83-58-39-114-115-40-59(76(112)113)92-72(108)57(38-95)91-75(111)63(43(3)97)94-71(107)54(33-46-23-11-6-12-24-46)90-74(110)62(42(2)96)93-66(102)51(28-16-18-30-78)84-69(105)55(34-47-36-81-49-26-14-13-25-48(47)49)88-68(104)53(32-45-21-9-5-10-22-45)86-67(103)52(31-44-19-7-4-8-20-44)87-70(106)56(35-60(80)98)89-65(101)50(85-73(58)109)27-15-17-29-77/h4-14,19-26,36,41-43,50-59,62-63,81,95-97H,15-18,27-35,37-40,77-79H2,1-3H3,(H2,80,98)(H,82,100)(H,83,99)(H,84,105)(H,85,109)(H,86,103)(H,87,106)(H,88,104)(H,89,101)(H,90,110)(H,91,111)(H,92,108)(H,93,102)(H,94,107)(H,112,113)/t41-,42+,43+,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,62-,63-/m0/s1;   InChIKey=NHXLMOGPVYXJNR-ATOGVRKGSA-N;   L-alanylglycyl-L-cysteinyl-L-lysyl-L-asparaginyl-L-phenylalanyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-cysteine cyclic (3-14) disulfide;   SMILES=C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)[C@@H](C)O)C(O)=O)NC(=O)CNC(=O)[C@H](C)N;   Somatostatin-1;   Somatostatin-14;   Synthetic growth hormone release-inhibiting hormone;   somatostatina;   somatostatine;   somatostatinum
 xref: CAS:38916-34-6;   Drug_Central:2997;   HMDB:HMDB0013072;   KEGG:C16022;   KEGG:D07431;   LINCS:LSM-5326
 xref_mesh: MESH:D013004
 xref: PMID:21922516;   PMID:22129035;   PMID:22147011;   PMID:22251942;   PMID:22483686;   PMID:22509294;   Reaxys:10148626;   Wikipedia:Somatostatin


show annotations for term's descendants       view all columns           Sort by:
 
somatostatin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Kcna5 potassium voltage-gated channel subfamily A member 5 JBrowse link 4 159,077,195 159,079,003 RGD:6480464
G Sstr1 somatostatin receptor 1 JBrowse link 6 79,252,914 79,258,611 RGD:6480464
G Sstr2 somatostatin receptor 2 JBrowse link 10 102,136,283 102,143,449 RGD:6480464
G Sstr3 somatostatin receptor 3 JBrowse link 7 119,760,881 119,768,082 RGD:6480464
G Sstr4 somatostatin receptor 4 JBrowse link 3 142,739,781 142,741,644 RGD:6480464
G Sstr5 somatostatin receptor 5 JBrowse link 10 14,847,749 14,853,827 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19717
      biological role 19716
        molecular messenger 18166
          hormone 17993
            peptide hormone 99
              somatostatin 6
                somatostatin-28 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19653
                    p-block element atom 19653
                      carbon group element atom 19548
                        carbon atom 19537
                          organic molecular entity 19537
                            organic group 18465
                              organic divalent group 18458
                                organodiyl group 18458
                                  carbonyl group 18354
                                    carbonyl compound 18354
                                      carboxylic acid 18033
                                        carboacyl group 17190
                                          univalent carboacyl group 17190
                                            carbamoyl group 16927
                                              carboxamide 16927
                                                peptide 9371
                                                  cyclic peptide 8723
                                                    heterodetic cyclic peptide 1438
                                                      somatostatin 6
                                                        somatostatin-28 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.