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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:lincomycin
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Accession:CHEBI:6472 term browser browse the term
Definition:A carbohydrate-containing antibiotic produced by the actinomyces Streptomyces lincolnensis.
Synonyms:exact_synonym: methyl 6,8-dideoxy-6-({[(2S,4R)-1-methyl-4-propylpyrrolidin-2-yl]carbonyl}amino)-1-thio-D-erythro-alpha-D-galacto-octopyranoside
 related_synonym: Cillimycin;   Formula=C18H34N2O6S;   InChI=1S/C18H34N2O6S/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25)/t9-,10-,11?,12-,13+,14-,15-,16-,18-/m1/s1;   InChIKey=OJMMVQQUTAEWLP-KIDUDLJLSA-N;   Methyl 6,8-dideoxy-6-trans-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-D-erythro-alpha-D-galacto-octopyranoside;   SMILES=CCC[C@@H]1C[C@H](N(C)C1)C(=O)N[C@H]([C@@H](C)O)[C@H]1O[C@H](SC)[C@H](O)[C@@H](O)[C@H]1O;   lincomicina;   lincomycine;   lincomycinum
 xref: CAS:154-21-2;   DrugBank:DB01627;   Drug_Central:1582;   HMDB:HMDB0015564;   KEGG:C06812;   KEGG:C14002;   KEGG:D00223;   KEGG:D02346;   LINCS:LSM-5602
 xref_mesh: MESH:D008034
 xref: PMID:24324587;   Reaxys:707677;   Wikipedia:Lincomycin


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lincomycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mr1 major histocompatibility complex, class I-related affects expression ISO Lincomycin affects the expression of MR1 mRNA CTD PMID:25811541 NCBI chr13:72,771,992...72,789,861
Ensembl chr13:72,771,984...72,789,841
JBrowse link
G RT1-S3 RT1 class Ib, locus S3 affects expression ISO Lincomycin affects the expression of HLA-E mRNA CTD PMID:25811541 NCBI chr20:3,176,124...3,180,825
Ensembl chr20:3,176,107...3,179,818
JBrowse link
clindamycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mmp13 matrix metallopeptidase 13 increases expression ISO Clindamycin results in increased expression of MMP13 mRNA CTD PMID:20338993 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 affects expression ISO Clindamycin affects the expression of HLA-DRB1 mRNA CTD PMID:25811541 NCBI chr20:4,087,621...4,097,190
Ensembl chr20:4,087,618...4,097,190
JBrowse link
G RT1-S3 RT1 class Ib, locus S3 affects expression ISO Clindamycin affects the expression of HLA-E mRNA CTD PMID:25811541 NCBI chr20:3,176,124...3,180,825
Ensembl chr20:3,176,107...3,179,818
JBrowse link
clindamycin phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pon1 paraoxonase 1 decreases activity ISO clindamycin phosphate results in decreased activity of PON1 protein CTD PMID:16880604 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        antimicrobial agent 17334
          lincomycin 5
            clindamycin + 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18114
                                        carboacyl group 17372
                                          univalent carboacyl group 17372
                                            carbamoyl group 17158
                                              carboxamide 17158
                                                monocarboxylic acid amide 14569
                                                  pyrrolidinecarboxamide 6
                                                    lincomycin 5
                                                      clindamycin + 4
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