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Accession:CHEBI:6520 term browser browse the term
Definition:An N-nitrosourea that is urea in which one of the nitrogens is substituted by a 2-chloroethyl group and by a nitroso group, while the other nitrogen is substituted by a cyclohexyl group. An alkylating antineoplastic agent, it is used in the treatment of brain tumours, lung cancer, malignant melanoma and other solid tumours.
Synonyms:related_synonym: 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea;   1-(2-chloroethyl)-3-cyclohexylnitrosourea;   Belustine;   CCNU;   CINU;   Cecenu;   CeeNU;   Formula=C9H16ClN3O2;   InChI=1S/C9H16ClN3O2/c10-6-7-13(12-15)9(14)11-8-4-2-1-3-5-8/h8H,1-7H2,(H,11,14);   InChIKey=GQYIWUVLTXOXAJ-UHFFFAOYSA-N;   N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea;   SMILES=ClCCN(N=O)C(=O)NC1CCCCC1;   chloroethylcyclohexylnitrosourea;   cyclohexyl chloroethyl nitrosourea;   lomustina;   lomustinum
 xref: CAS:13010-47-4 "ChemIDplus";   CAS:13010-47-4 "KEGG COMPOUND";   DrugBank:DB01206;   Drug_Central:1596 "DrugCentral";   HMDB:HMDB0015337;   KEGG:C07079;   KEGG:D00363
 xref_mesh: MESH:D008130
 xref: PMID:12153595 "Europe PMC";   PMID:19901016 "Europe PMC";   PMID:20719460 "Europe PMC";   PMID:22577051 "Europe PMC";   PMID:24293673 "Europe PMC";   PMID:24368412 "Europe PMC";   PMID:24516018 "Europe PMC";   PMID:6762924 "Europe PMC";   Reaxys:2125058 "Reaxys";   Wikipedia:Lomustine

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lomustine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 7 70,578,564 70,585,074 RGD:6480464
G Ina internexin neuronal intermediate filament protein, alpha JBrowse link 1 266,782,835 266,794,389 RGD:6480464
G Mgmt O-6-methylguanine-DNA methyltransferase JBrowse link 1 209,237,255 209,464,189 RGD:6480464
G Polh DNA polymerase eta JBrowse link 9 17,163,354 17,198,006 RGD:6480464
G Socs1 suppressor of cytokine signaling 1 JBrowse link 10 4,956,795 4,958,472 RGD:6480464
G Srxn1 sulfiredoxin 1 JBrowse link 3 147,608,850 147,614,410 RGD:6480464
G Stmn1 stathmin 1 JBrowse link 5 152,680,412 152,686,807 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19741
    role 19688
      application 19339
        pharmaceutical 19214
          drug 19214
            antineoplastic agent 16873
              lomustine 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19741
    subatomic particle 19737
      composite particle 19737
        hadron 19737
          baryon 19737
            nucleon 19737
              atomic nucleus 19737
                atom 19737
                  main group element atom 19622
                    p-block element atom 19622
                      carbon group element atom 19515
                        carbon atom 19508
                          organic molecular entity 19508
                            organic group 18423
                              organic divalent group 18414
                                organodiyl group 18414
                                  carbonyl group 18301
                                    carbonyl compound 18301
                                      carboxylic acid 17966
                                        carboacyl group 17073
                                          univalent carboacyl group 17073
                                            carbamoyl group 16800
                                              carboxamide 16800
                                                monocarboxylic acid amide 14162
                                                  urea 4946
                                                    ureas 4944
                                                      N-nitrosoureas 1905
                                                        lomustine 9
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.