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Term:ageladine A
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Accession:CHEBI:65373 term browser browse the term
Definition:An imidazopyridine that is 1H-imidazo[4,5-c]pyridin-2-amine substituted by a 4,5-dibromo-1H-pyrrol-2-yl group at position 4. It is an alkaloid isolated from a marine sponge Agelas nakamurai and acts as an inhibitor of the matrix metalloproteinases, the key enzymes involved in tumour growth, migration, angiogenesis, invasion and metastasis.
Synonyms:exact_synonym: 4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine
 related_synonym: Formula=C10H7Br2N5;   InChI=1S/C10H7Br2N5/c11-4-3-6(15-9(4)12)7-8-5(1-2-14-7)16-10(13)17-8/h1-3,15H,(H3,13,16,17);   InChIKey=QAKGJAQGTQLMFN-UHFFFAOYSA-N;   SMILES=Nc1nc2c(nccc2[nH]1)-c1cc(Br)c(Br)[nH]1
 xref_mesh: MESH:C482289
 xref: PMID:14677933 "Europe PMC";   PMID:16562912 "Europe PMC";   PMID:17261003 "Europe PMC";   PMID:19948404 "Europe PMC";   PMID:22363232 "Europe PMC";   Patent:WO2009152584;   Reaxys:9568941 "Reaxys"

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ageladine A term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A JBrowse link 11 34,858,339 34,958,733 RGD:6480464
G Mmp14 matrix metallopeptidase 14 JBrowse link 15 33,074,441 33,083,666 RGD:6480464
G Mmp2 matrix metallopeptidase 2 JBrowse link 19 15,542,771 15,570,589 RGD:6480464
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase JBrowse link 20 8,165,423 8,169,557 RGD:6480464

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  CHEBI ontology 19741
    role 19688
      biological role 19686
        biochemical role 19190
          metabolite 19162
            ageladine A 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19741
    subatomic particle 19737
      composite particle 19737
        hadron 19737
          baryon 19737
            nucleon 19737
              atomic nucleus 19737
                atom 19737
                  main group element atom 19622
                    p-block element atom 19622
                      carbon group element atom 19515
                        carbon atom 19508
                          organic molecular entity 19508
                            organic molecule 19431
                              organic cyclic compound 19197
                                organic heterocyclic compound 18267
                                  heteroarene 15809
                                    monocyclic heteroarene 13124
                                      azole 12254
                                        pyrroles 5860
                                          ageladine A 4
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.