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Term:fomitopinic acid A
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Accession:CHEBI:65902 term browser browse the term
Definition:A tetracyclic triterpenoid that is lanost-8-ene substituted by hydroxy groups at positions 24 and 25 , a carboxylic acid at position 21 and an oxo grouo at position 3 (the 24S stereoisomer). Isolated from the fruit bodies of Fomitopsis pinicola, it exhibits antiinflammatory activity against cylooxygenase-1 (COX-1) and cylooxygenase-2 (COX-2).
Synonyms:exact_synonym: (24S)-24,25-dihydroxy-3-oxolanost-8-en-21-oic acid
 related_synonym: Formula=C30H48O5;   InChI=1S/C30H48O5/c1-26(2)22-10-9-21-20(28(22,5)15-14-23(26)31)13-17-29(6)19(12-16-30(21,29)7)18(25(33)34)8-11-24(32)27(3,4)35/h18-19,22,24,32,35H,8-17H2,1-7H3,(H,33,34)/t18-,19-,22+,24+,28-,29-,30+/m1/s1;   InChIKey=GCGLPSVDVGXRFN-AMKDLFIQSA-N;   SMILES=[H][C@@]1(CC[C@@]2(C)C3=C(CC[C@]12C)[C@@]1(C)CCC(=O)C(C)(C)[C@]1([H])CC3)[C@@H](CC[C@H](O)C(C)(C)O)C(O)=O
 xref: PMID:15679320 "Europe PMC";   Reaxys:10224261 "Reaxys"

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  CHEBI ontology 19745
    role 19692
      biological role 19690
        biochemical role 19188
          metabolite 19159
            fomitopinic acid A 0
Path 2
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  CHEBI ontology 19745
    subatomic particle 19741
      composite particle 19741
        hadron 19741
          baryon 19741
            nucleon 19741
              atomic nucleus 19741
                atom 19741
                  main group element atom 19625
                    p-block element atom 19625
                      carbon group element atom 19519
                        carbon atom 19513
                          organic molecular entity 19513
                            organic group 18424
                              organic divalent group 18416
                                organodiyl group 18416
                                  carbonyl group 18304
                                    carbonyl compound 18304
                                      carboxylic acid 17970
                                        monocarboxylic acid 17266
                                          oxo monocarboxylic acid 6256
                                            fomitopinic acid A 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.