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ONTOLOGY REPORT - ANNOTATIONS


Term:lycorine
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Accession:CHEBI:6601 term browser browse the term
Definition:An indolizidine alkaloid that is 3,12-didehydrogalanthan substituted by hydroxy groups at positions and 2 and a methylenedioxy group across positions 9 and 10. Isolated from Crinum asiaticum, it has been shown to exhibit antimalarial activity.
Synonyms:exact_synonym: 9,10-(methylenedioxy)-3,12-didehydrogalanthan-1alpha,2beta-diol
 related_synonym: Amarylline;   Formula=C16H17NO4;   Galanthidine;   InChI=1S/C16H17NO4/c18-11-3-8-1-2-17-6-9-4-12-13(21-7-20-12)5-10(9)14(15(8)17)16(11)19/h3-5,11,14-16,18-19H,1-2,6-7H2/t11-,14-,15+,16+/m0/s1;   InChIKey=XGVJWXAYKUHDOO-DANNLKNASA-N;   Licorine;   Narcissine;   SMILES=[H][C@]12[C@H](O)[C@@H](O)C=C3CCN(Cc4cc5OCOc5cc14)[C@@]23[H]
 xref: Beilstein:93605 "Beilstein";   CAS:476-28-8 "ChemIDplus";   CAS:476-28-8 "KEGG COMPOUND";   KEGG:C08532;   KNApSAcK:C00001576
 xref_mesh: MESH:C015330
 xref: PDBeChem:3KD;   PMID:12232602 "Europe PMC";   PMID:14669261 "Europe PMC";   PMID:15386196 "Europe PMC";   PMID:19788245 "Europe PMC";   Reaxys:93605 "Reaxys"


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lycorine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccnd3 cyclin D3 JBrowse link 9 15,404,816 15,410,905 RGD:6480464
G Cdh5 cadherin 5 JBrowse link 19 1,025,122 1,074,333 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Mapk14 mitogen activated protein kinase 14 JBrowse link 20 5,933,290 5,995,137 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Sema4d semaphorin 4D JBrowse link 17 13,516,276 13,538,513 RGD:6480464
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:6480464
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19749
    role 19696
      biological role 19694
        biochemical role 19192
          metabolite 19164
            alkaloid 5281
              indolizidine alkaloid 12
                lycorine 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 19749
    subatomic particle 19745
      composite particle 19745
        hadron 19745
          baryon 19745
            nucleon 19745
              atomic nucleus 19745
                atom 19745
                  main group element atom 19630
                    p-block element atom 19630
                      carbon group element atom 19523
                        carbon atom 19517
                          organic molecular entity 19517
                            organic molecule 19434
                              organic cyclic compound 19203
                                organic heterocyclic compound 18272
                                  organic heteropolycyclic compound 17577
                                    organic heterobicyclic compound 16244
                                      indolizines 21
                                        indolizidine alkaloid 12
                                          galanthan 12
                                            lycorine 12
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.