Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:jaspamide
go back to main search page
Accession:CHEBI:66104 term browser browse the term
Definition:A cyclodepsipeptide isolated from Jaspis splendens and has been shown to exhibit antineoplastic activity.
Synonyms:exact_synonym: (4R,7R,10S,13S,15E,17R,19S)-7-[(2-bromo-1H-indol-3-yl)methyl]-4-(4-hydroxyphenyl)-8,10,13,15,17,19-hexamethyl-1-oxa-5,8,11-triazacyclononadec-15-ene-2,6,9,12-tetrone
 related_synonym: Formula=C36H45BrN4O6;   InChI=1S/C36H45BrN4O6/c1-20-15-21(2)17-23(4)47-32(43)19-30(25-11-13-26(42)14-12-25)40-35(45)31(18-28-27-9-7-8-10-29(27)39-33(28)37)41(6)36(46)24(5)38-34(44)22(3)16-20/h7-15,21-24,30-31,39,42H,16-19H2,1-6H3,(H,38,44)(H,40,45)/b20-15+/t21-,22-,23-,24-,30+,31+/m0/s1;   InChIKey=GQWYWHOHRVVHAP-DHKPLNAMSA-N;   Jasplakinolide;   SMILES=C[C@H]1C[C@@H](C)\\C=C(C)\\C[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc2c(Br)[nH]c3ccccc23)C(=O)N[C@H](CC(=O)O1)c1ccc(O)cc1;   beta-Alanine, N-(2-bromo-N-(N-(8-hydroxy-2,4,6-trimethyl-1-oxo-4-nonenyl)-L-alanyl)-N-methyl-D-tryptophyl)-L-3-(4-hydroxyphenyl)-, p-lactone, (2S-(2R*,4E,6S*,8R*))-
 xref: CAS:102396-24-7;   KEGG:C16883
 xref_mesh: MESH:C057531
 xref: PMID:20678932;   PMID:21241058;   PMID:22115418;   PMID:23261645;   Patent:KR20030085421;   Reaxys:4649870


show annotations for term's descendants           Sort by:
 
jaspamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle increases expression ISO
EXP
jasplakinolide results in increased expression of ACTA2 protein
jasplakinolide results in increased expression of ACTA2 mRNA
CTD PMID:11035001, PMID:23517783 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Actg1 actin, gamma 1 multiple interactions ISO jasplakinolide inhibits the reaction [UPF1 protein binds to ACTG1 protein]; jasplakinolide inhibits the reaction [UPF2 protein binds to ACTG1 protein]; jasplakinolide inhibits the reaction [UPF3B protein binds to ACTG1 protein] CTD PMID:28743738 NCBI chr10:109,518,429...109,521,288
Ensembl chr 3:75,643,054...75,644,954
Ensembl chr10:75,643,054...75,644,954
JBrowse link
G Ahnak AHNAK nucleoprotein multiple interactions ISO jasplakinolide inhibits the reaction [AHNAK protein affects the expression of CDH1 protein]; jasplakinolide inhibits the reaction [AHNAK protein affects the expression of CDH2 protein]; jasplakinolide inhibits the reaction [AHNAK protein affects the expression of VIM protein]; jasplakinolide inhibits the reaction [AHNAK protein affects the localization of SNAI1 protein] CTD PMID:20388789 NCBI chr 1:225,184,883...225,429,638
Ensembl chr 1:225,184,939...225,215,015
JBrowse link
G Ccn1 cellular communication network factor 1 multiple interactions
increases expression
ISO jasplakinolide results in increased expression of and results in increased secretion of CCN1 protein; YAP1 protein affects the reaction [jasplakinolide results in increased expression of CCN1 protein]
jasplakinolide results in increased expression of CCN1 mRNA
CTD PMID:24040060 NCBI chr 2:251,529,354...251,532,312
Ensembl chr 2:251,529,354...251,532,312
JBrowse link
G Ccn2 cellular communication network factor 2 increases expression
multiple interactions
ISO jasplakinolide results in increased expression of CCN2 mRNA
jasplakinolide results in increased expression of and results in increased secretion of CCN2 protein; YAP1 protein affects the reaction [jasplakinolide results in increased expression of CCN2 protein]
CTD PMID:24040060, PMID:25690654 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Cdh1 cadherin 1 decreases expression
multiple interactions
ISO jasplakinolide results in decreased expression of CDH1 protein
jasplakinolide inhibits the reaction [AHNAK protein affects the expression of CDH1 protein]; jasplakinolide inhibits the reaction [EIF4E protein affects the expression of CDH1 protein]; jasplakinolide inhibits the reaction [S100A1 protein affects the expression of CDH1 protein]; jasplakinolide inhibits the reaction [SEPTIN9 protein affects the expression of CDH1 protein]
CTD PMID:20388789, PMID:25756282 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO jasplakinolide inhibits the reaction [AHNAK protein affects the expression of CDH2 protein]; jasplakinolide inhibits the reaction [EIF4E protein affects the expression of CDH2 protein]; jasplakinolide inhibits the reaction [S100A1 protein affects the expression of CDH2 protein]; jasplakinolide inhibits the reaction [SEPTIN9 protein affects the expression of CDH2 protein] CTD PMID:20388789 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Cdh5 cadherin 5 multiple interactions ISO jasplakinolide inhibits the reaction [Ethanol results in increased uptake of CDH5 protein] CTD PMID:22331491 NCBI chr19:1,025,122...1,074,333
Ensembl chr19:1,023,683...1,074,365
JBrowse link
G Ctnna1 catenin alpha 1 multiple interactions EXP jasplakinolide affects the reaction [CTNNA1 protein affects the susceptibility to Cisplatin] CTD PMID:27989596 NCBI chr18:27,923,229...28,055,972
Ensembl chr18:27,923,572...28,055,960
JBrowse link
G Diaph1 diaphanous-related formin 1 affects localization ISO jasplakinolide affects the localization of DIAPH1 protein CTD PMID:22918941 NCBI chr18:30,972,907...31,071,371
Ensembl chr18:30,972,907...31,071,371
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions ISO jasplakinolide inhibits the reaction [EIF4E protein affects the expression of CDH1 protein]; jasplakinolide inhibits the reaction [EIF4E protein affects the expression of CDH2 protein]; jasplakinolide inhibits the reaction [EIF4E protein affects the expression of VIM protein]; jasplakinolide inhibits the reaction [EIF4E protein affects the localization of SNAI1 protein] CTD PMID:20388789 NCBI chr 2:243,819,616...243,853,987
Ensembl chr 2:243,820,661...243,852,631
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression
multiple interactions
ISO jasplakinolide results in increased expression of GDF15 mRNA; jasplakinolide results in increased expression of GDF15 protein
[SB 203580 co-treated with 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine] inhibits the reaction [jasplakinolide results in increased expression of GDF15 protein]
CTD PMID:23996089 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Gpx1 glutathione peroxidase 1 affects localization ISO jasplakinolide affects the localization of GPX1 mRNA mutant form CTD PMID:28743738 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO jasplakinolide inhibits the reaction [TNF protein affects the localization of ICAM1 protein] CTD PMID:15034928 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma multiple interactions ISO jasplakinolide promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA] CTD PMID:12799187 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
jasplakinolide promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]
jasplakinolide inhibits the reaction [latrunculin B promotes the reaction [IL1B protein results in increased expression of NOS2 protein]]
CTD PMID:11502570, PMID:12799187 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Mrtfa myocardin related transcription factor A affects localization ISO jasplakinolide affects the localization of MRTFA protein CTD PMID:23517783 NCBI chr 7:122,233,196...122,403,661
Ensembl chr 7:122,234,012...122,403,667
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
jasplakinolide promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]
jasplakinolide inhibits the reaction [latrunculin B promotes the reaction [IL1B protein results in increased expression of NOS2 protein]]
CTD PMID:11502570, PMID:12799187 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G P2rx1 purinergic receptor P2X 1 multiple interactions
affects localization
ISO jasplakinolide inhibits the reaction [Cholesterol deficiency results in decreased activity of P2RX1 protein]
jasplakinolide affects the localization of P2RX1 protein
CTD PMID:21757694 NCBI chr10:59,566,268...59,581,328
Ensembl chr10:59,566,223...59,581,325
JBrowse link
G Rs1 retinoschisin 1 decreases secretion ISO jasplakinolide results in decreased secretion of RS1 protein CTD PMID:21738583 NCBI chr  X:35,749,957...35,777,243
Ensembl chr  X:35,749,957...35,777,243
JBrowse link
G S100a1 S100 calcium binding protein A1 multiple interactions ISO jasplakinolide inhibits the reaction [S100A1 protein affects the expression of CDH1 protein]; jasplakinolide inhibits the reaction [S100A1 protein affects the expression of CDH2 protein]; jasplakinolide inhibits the reaction [S100A1 protein affects the expression of VIM protein]; jasplakinolide inhibits the reaction [S100A1 protein affects the localization of SNAI1 protein] CTD PMID:20388789 NCBI chr 2:189,900,505...189,905,348
Ensembl chr 2:189,900,667...189,903,219
JBrowse link
G Septin9 septin 9 multiple interactions ISO jasplakinolide inhibits the reaction [SEPTIN9 protein affects the expression of CDH1 protein]; jasplakinolide inhibits the reaction [SEPTIN9 protein affects the expression of CDH2 protein]; jasplakinolide inhibits the reaction [SEPTIN9 protein affects the expression of VIM protein]; jasplakinolide inhibits the reaction [SEPTIN9 protein affects the localization of SNAI1 protein] CTD PMID:20388789 NCBI chr10:106,208,308...106,340,747
Ensembl chr10:106,264,434...106,348,490
JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions ISO jasplakinolide inhibits the reaction [AHNAK protein affects the localization of SNAI1 protein]; jasplakinolide inhibits the reaction [EIF4E protein affects the localization of SNAI1 protein]; jasplakinolide inhibits the reaction [S100A1 protein affects the localization of SNAI1 protein]; jasplakinolide inhibits the reaction [SEPTIN9 protein affects the localization of SNAI1 protein] CTD PMID:20388789 NCBI chr 3:164,274,710...164,279,199
Ensembl chr 3:164,274,710...164,279,378
JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression ISO jasplakinolide results in decreased expression of SPP1 protein CTD PMID:19026636 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Srf serum response factor increases activity ISO jasplakinolide results in increased activity of SRF protein CTD PMID:11502570 NCBI chr 9:16,737,637...16,747,226
Ensembl chr 9:16,737,642...16,747,225
JBrowse link
G Tagln transgelin increases expression ISO
EXP
jasplakinolide results in increased expression of TAGLN protein
jasplakinolide results in increased expression of TAGLN mRNA
CTD PMID:11035001, PMID:15184395 NCBI chr 8:50,222,895...50,228,369
Ensembl chr 8:50,222,896...50,231,357
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO jasplakinolide inhibits the reaction [TNF protein affects the localization of ICAM1 protein]; jasplakinolide inhibits the reaction [TNF protein affects the localization of VCAM1 protein]; jasplakinolide promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA] CTD PMID:12799187, PMID:15034928 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Upf1 UPF1, RNA helicase and ATPase affects localization
multiple interactions
ISO jasplakinolide affects the localization of UPF1 protein
jasplakinolide inhibits the reaction [UPF1 protein binds to ACTG1 protein]
CTD PMID:28743738 NCBI chr16:20,824,888...20,845,632
Ensembl chr16:20,824,864...20,845,243
JBrowse link
G Upf2 UPF2, regulator of nonsense mediated mRNA decay multiple interactions ISO jasplakinolide inhibits the reaction [UPF2 protein binds to ACTG1 protein] CTD PMID:28743738 NCBI chr17:76,176,379...76,287,246
Ensembl chr17:76,175,643...76,287,186
JBrowse link
G Upf3b UPF3B, regulator of nonsense mediated mRNA decay multiple interactions
affects localization
ISO jasplakinolide inhibits the reaction [UPF3B protein binds to ACTG1 protein]
jasplakinolide affects the localization of UPF3B protein
CTD PMID:28743738 NCBI chr  X:123,713,327...123,731,431
Ensembl chr  X:123,713,339...123,731,385
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO jasplakinolide inhibits the reaction [TNF protein affects the localization of VCAM1 protein] CTD PMID:15034928 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vim vimentin multiple interactions ISO jasplakinolide inhibits the reaction [AHNAK protein affects the expression of VIM protein]; jasplakinolide inhibits the reaction [EIF4E protein affects the expression of VIM protein]; jasplakinolide inhibits the reaction [S100A1 protein affects the expression of VIM protein]; jasplakinolide inhibits the reaction [SEPTIN9 protein affects the expression of VIM protein] CTD PMID:20388789 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Yap1 Yes1 associated transcriptional regulator multiple interactions ISO jasplakinolide results in decreased phosphorylation of and affects the localization of YAP1 protein; YAP1 protein affects the reaction [jasplakinolide results in increased expression of CCN1 protein]; YAP1 protein affects the reaction [jasplakinolide results in increased expression of CCN2 protein] CTD PMID:24040060 NCBI chr 8:6,133,014...6,204,240
Ensembl chr 8:6,135,493...6,203,579
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        biochemical role 19313
          apoptosis inducer 10979
            jaspamide 33
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18114
                                        carboacyl group 17372
                                          univalent carboacyl group 17372
                                            carbamoyl group 17158
                                              carboxamide 17158
                                                peptide 9396
                                                  depsipeptide 356
                                                    cyclodepsipeptide 337
                                                      jaspamide 33
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.